An Up-to-Date Review of Natural Nanoparticles for Cancer Management

Ion, Daniel; Niculescu, Adelina-Gabriela; Păduraru, Dan Nicolae; Andronic, Octavian; Mușat, Florentina; Grumezescu, Alexandru Mihai; Bolocan, Alexandra

doi:10.3390/pharmaceutics14010018

Cited by 36 publications

(16 citation statements)

References 193 publications

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“…Under this circumstance, researchers around the world have explored a variety of new nanocarriers and targeted modification systems to overcome these shortcomings and improve the therapeutic outcomes ( Ghaz-Jahanian et al, 2015 ; Bai et al, 2021 ; Shakeran et al, 2021 ; Dubey et al, 2022 ). Because nanotechnology provides a suitable means for the targeted and time-controlled delivery of drugs and other bioactive agents, it has been widely studied in drug delivery and has potential application prospects in cancer treatment ( Sabra et al, 2017 ; George et al, 2019 ; Ion et al, 2021 ; Maspes et al, 2021 ; Sohrabi and Packirisamy, 2021 ; Li et al, 2022 ). Drug delivery systems (DDSs) refer to the methods of delivering drugs to the targeted tissues, organs, cells or subcellular organs through various drug carriers for controlling drug release and absorption, so as to improve the pharmacological activity, overcome the limited solubility, low bioavailability, poor biological distribution and lack of selectivity, or to minimize the adverse effects ( Li et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Ding

Guo

2022

Front. Pharmacol.

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Cancer has become a main public health issue globally. The conventional treatment measures for cancer include surgery, radiotherapy and chemotherapy. Among the various available treatment measures, chemotherapy is still one of the most important treatments for most cancer patients. However, chemotherapy for most cancers still faces many problems associated with a lot of adverse effects, which limit its therapeutic potency, low survival quality and discount cancer prognosis. In order to decrease these side effects and improve treatment effectiveness and patient’s compliance, more targeted treatments are needed. Sustainable and controlled deliveries of drugs with controllable toxicities are expected to address these hurdles. Chitosan is the second most abundant natural polysaccharide, which has excellent biocompatibility and notable antitumor activity. Its biodegradability, biocompatibility, biodistribution, nontoxicity and immunogenicity free have made chitosan become a widely used polymer in the pharmacology, especially in oncotherapy. Here, we make a brief review of the main achievements in chitosan and its derivatives in pharmacology with a special focus on their agents delivery applications, immunomodulation, signal pathway modulation and antitumor activity to highlight their role in cancer treatment. Despite a large number of successful studies, the commercialization of chitosan copolymers is still a big challenge. The further development of polymerization technology may satisfy the unmet medical needs.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Ding

Guo

2022

Front. Pharmacol.

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“…Both viruses and EVs have a wide range of therapeutic applications. EVs have reached clinical trials for a wide variety of different illnesses—from cancer [ 120 , 121 , 122 , 123 ] to cardiovascular disease, type 1 diabetes, neurodegenerative diseases (Huntington’s disease, Parkinson’s disease) [ 124 ], autoimmune and inflammatory diseases [ 125 ], and even for acute respiratory distress syndrome (ARDS) from SARS-CoV-2 infection [ 126 ]. Similarly, viral vectors have been used for vaccine development for decades and are now being readily explored for gene therapies, vaccines and oncolytic viral therapies [ 127 , 128 , 129 , 130 ].…”

Section: Evs and Viruses As Therapeutic Toolsmentioning

confidence: 99%

Extracellular Vesicles and Viruses: Two Intertwined Entities

Moulin

Crupi

Ilkow

et al. 2023

IJMS

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Viruses share many attributes in common with extracellular vesicles (EVs). The cellular machinery that is used for EV production, packaging of substrates and secretion is also commonly manipulated by viruses for replication, assembly and egress. Viruses can increase EV production or manipulate EVs to spread their own genetic material or proteins, while EVs can play a key role in regulating viral infections by transporting immunomodulatory molecules and viral antigens to initiate antiviral immune responses. Ultimately, the interactions between EVs and viruses are highly interconnected, which has led to interesting discoveries in their associated roles in the progression of different diseases, as well as the new promise of combinational therapeutics. In this review, we summarize the relationships between viruses and EVs and discuss major developments from the past five years in the engineering of virus-EV therapies.

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“…Numerous studies on the use of various herbal remedies and natural items in the treatment of PD have been conducted over the past few years and have been explained below ( Ion et al, 2021 ).…”

Section: Phytoconstituents In Different Neurological Disordersmentioning

confidence: 99%

Natural product-based pharmacological studies for neurological disorders

Puri

Kanojia²,

Sharma³

et al. 2022

Front. Pharmacol.

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Central nervous system (CNS) disorders and diseases are expected to rise sharply in the coming years, partly because of the world’s aging population. Medicines for the treatment of the CNS have not been successfully made. Inadequate knowledge about the brain, pharmacokinetic and dynamic errors in preclinical studies, challenges with clinical trial design, complexity and variety of human brain illnesses, and variations in species are some potential scenarios. Neurodegenerative diseases (NDDs) are multifaceted and lack identifiable etiological components, and the drugs developed to treat them did not meet the requirements of those who anticipated treatments. Therefore, there is a great demand for safe and effective natural therapeutic adjuvants. For the treatment of NDDs and other memory-related problems, many herbal and natural items have been used in the Ayurvedic medical system. Anxiety, depression, Parkinson’s, and Alzheimer’s diseases (AD), as well as a plethora of other neuropsychiatric disorders, may benefit from the use of plant and food-derived chemicals that have antidepressant or antiepileptic properties. We have summarized the present level of knowledge about natural products based on topological evidence, bioinformatics analysis, and translational research in this review. We have also highlighted some clinical research or investigation that will help us select natural products for the treatment of neurological conditions. In the present review, we have explored the potential efficacy of phytoconstituents against neurological diseases. Various evidence-based studies and extensive recent investigations have been included, which will help pharmacologists reduce the progression of neuronal disease.

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An Up-to-Date Review of Natural Nanoparticles for Cancer Management

Cited by 36 publications

References 193 publications

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Extracellular Vesicles and Viruses: Two Intertwined Entities

Natural product-based pharmacological studies for neurological disorders

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