An Up-To-Date Review on Biomedical Applications of Palladium Nanoparticles

Phan, Thi Tuong Vy; Huynh, Thanh‐Canh; Manivasagan, Panchanathan; Mondal, Sudip; Oh, Junghwan

doi:10.3390/nano10010066

Cited by 123 publications

(67 citation statements)

References 102 publications

(199 reference statements)

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“…Microorganisms (MOs), algae, and plant extracts were used for the bioreduction of metals [ 26 , 27 , 28 ]. The biosynthesis of Pd NPs is a safe, clean, and eco-friendly approach to produce NPs of versatile sizes, shapes, physical, chemical, and biological properties [ 29 ].…”

Section: Green Synthesis Of Pd Npsmentioning

confidence: 99%

“…However, the use of MOs in the green synthesis involves a sophisticated and time-consuming multistep process. The localized heating (employing microwave heat, for instance) needed for the NPs to be created could deform the MOs enzymes required for the bioreduction to take place [ 29 , 32 ]. Additionally, many aspects should be considered in the process of producing Pd NPs using MOs, such as the careful selection of the most appropriate MO because each one interacts differently with metal ions according to the intrinsic enzymatic activity and biochemical processes.…”

Section: Green Synthesis Of Pd Npsmentioning

confidence: 99%

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Palladium Nanoparticles Fabricated by Green Chemistry: Promising Chemotherapeutic, Antioxidant and Antimicrobial Agents

et al. 2020

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Palladium nanoparticles (Pd NPs) showed great potential in biomedical applications because of their unique physicochemical properties. Various conventional physical and chemical methods have been used for the synthesis of Pd NPs. However, these methods include the use of hazardous reagents and reaction conditions, which may be toxic to health and to the environment. Thus, eco-friendly, rapid, and economic approaches for the synthesis of Pd NPs have been developed. Bacteria, fungi, yeast, seaweeds, plants, and plant extracts were used to prepare Pd NPs. This review highlights the most recent studies for the biosynthesis of Pd NPs, factors controlling their synthesis, and their potential biomedical applications.

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Section: Green Synthesis Of Pd Npsmentioning

confidence: 99%

Section: Green Synthesis Of Pd Npsmentioning

confidence: 99%

Palladium Nanoparticles Fabricated by Green Chemistry: Promising Chemotherapeutic, Antioxidant and Antimicrobial Agents

et al. 2020

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“…In this nano-era, NPs from all kinds of raw materials have been tried to provide the designed drug-controlled release profiles, such as polymer, lipid, inorganic, and magnetic substances [ 11 , 70 , 71 , 72 , 73 , 74 ]. Based on the present protocols, there are some new strategies that can be applied for developing novel polymer coating NPs.…”

Section: Resultsmentioning

confidence: 99%

Electrosprayed Ultra-Thin Coating of Ethyl Cellulose on Drug Nanoparticles for Improved Sustained Release

Huang

Hanlin

et al. 2020

Nanomaterials

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In nanopharmaceutics, polymeric coating is a popular strategy for modifying the drug release kinetics and, thus, new methods for implementing the nanocoating processes are highly desired. In the present study, a modified coaxial electrospraying process was developed to formulate an ultra-thin layer of ethyl cellulose (EC) on a medicated composite core consisting of tamoxifen citrate (TAM) and EC. A traditional single-fluid blending electrospraying and its monolithic EC-TAM nanoparticles (NPs) were exploited to compare. The modified coaxial processes were demonstrated to be more continuous and robust. The created NPs with EC coating had a higher quality than the monolithic ones in terms of the shape, surface smoothness, and the uniform size distribution, as verified by the SEM and TEM results. XRD patterns suggested that TAM presented in all the NPs in an amorphous state thanks to the fine compatibility between EC and TAM, as indicated by the attenuated total reflection (ATR)-FTIR spectra. In vitro dissolution tests demonstrated that the NPs with EC coating required a time period of 7.58 h, 12.79 h, and 28.74 h for an accumulative release of 30%, 50%, and 90% of the loaded drug, respectively. The protocols reported here open a new way for developing novel medicated nanoparticles with functional coating.

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“…Palladium nanoparticles provide excellent physiochemical properties including catalytic activities, optical properties, as well as strong thermal and chemical stability (Phan et al, 2020 ). Currently, palladium nanoparticles are used in dental applications, and needle-shaped palladium nanoparticles are clinically utilized for prostate and melanoma treatment (Phan et al, 2020 ). Typically, spherical palladium nanoparticles demonstrate poor NIR absorption efficiency and limited SPR activity.…”

Section: External Stimuli-responsive Metallic Nanotherapeuticsmentioning

confidence: 99%

External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy

Mohapatra

Uthaman

Park

2021

Front. Mol. Biosci.

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Therapeutic, diagnostic, and imaging approaches based on nanotechnology offer distinct advantages in cancer treatment. Various nanotherapeutics have been presented as potential alternatives to traditional anticancer therapies such as chemotherapy, radiotherapy, and surgical intervention. Notably, the advantage of nanotherapeutics is mainly attributable to their accumulation and targeting ability toward cancer cells, multiple drug-carrying abilities, combined therapies, and imaging approaches. To date, numerous nanoparticle formulations have been developed for anticancer therapy and among them, metallic nanotherapeutics reportedly demonstrate promising cancer therapeutic and diagnostic efficiencies owing to their dense surface functionalization ability, uniform size distribution, and shape-dependent optical responses, easy and cost-effective synthesis procedure, and multiple anti-cancer effects. Metallic nanotherapeutics can remodel the tumor microenvironment by changing unfavorable therapeutic conditions into therapeutically accessible ones with the help of different stimuli, including light, heat, ultrasound, an alternative magnetic field, redox, and reactive oxygen species. The combination of metallic nanotherapeutics with both external and internal stimuli can be used to trigger the on-demand release of therapeutic molecules, augmenting the therapeutic efficacies of anticancer therapies such as photothermal therapy, photodynamic therapy, magnetic hyperthermia, sonodynamic therapy, chemodynamic therapy, and immunotherapy. In this review, we have summarized the role of different metallic nanotherapeutics in anti-cancer therapy, as well as their combinational effects with multiple stimuli for enhanced anticancer therapy.

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An Up-To-Date Review on Biomedical Applications of Palladium Nanoparticles

Cited by 123 publications

References 102 publications

Palladium Nanoparticles Fabricated by Green Chemistry: Promising Chemotherapeutic, Antioxidant and Antimicrobial Agents

Palladium Nanoparticles Fabricated by Green Chemistry: Promising Chemotherapeutic, Antioxidant and Antimicrobial Agents

Electrosprayed Ultra-Thin Coating of Ethyl Cellulose on Drug Nanoparticles for Improved Sustained Release

External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy

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