An Upconversion Nanoparticle with Orthogonal Emissions Using Dual NIR Excitations for Controlled Two‐Way Photoswitching

Lai, Jinping; Zhang, Yixiao; Pasquale, Nicholas; Lee, Ki‐Bum

doi:10.1002/anie.201408219

Cited by 143 publications

(113 citation statements)

References 66 publications

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“…[5d] Despite current strategies for orthogonal excitations-emissions UCL, most of them are based on tuning of the excitation power density, [5] which could induce severe local heating under the high power density.I na ddition, the emission colors are not fixed under different excitation power density.T hus,t oo vercome these limitations,i ti sd esirable to develop power density-independent orthogonal excitations-emissions UCNPs.…”

Section: Lanthanide-doped Upconversion Nanoparticles (Ucnps)mentioning

confidence: 99%

Filtration Shell Mediated Power Density Independent Orthogonal Excitations–Emissions Upconversion Luminescence

Guo

Zhao

et al. 2016

Angewandte Chemie

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Lanthanide doped core-multishell structured NaGdF 4 :Yb,Er@NaYF 4 :Yb@NaGdF 4 :Yb,Nd@NaYF 4 @-NaGdF 4 :Yb,Tm@NaYF 4 nanoparticles with power-density independent orthogonal excitations-emissions upconversion luminescence (UCL) were fabricated for the first time.T he optical properties of these core-multishell structured nanoparticles were related to the absorption filtration effect of the NaGdF 4 :Yb,Tm layer.Bytuning the thickness of the filtration layer,t he nanoparticles can exhibit unique two independent groups of UCL:T m 3+ prominent UV/blue (UV = ultraviolet) UCL under the excitation at 980 nm and Er 3+ prominent green/ red UCL under the excitation at 796 nm. The filtration-shell mediated orthogonal excitations-emissions UCL are powerdensity independent. As aproof of concept, the core-multishell nanoparticles are used in multi-dimensional security design and imaging-guided combined photodynamic therapya nd chemotherapy.

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Section: Lanthanide-doped Upconversion Nanoparticles (Ucnps)mentioning

confidence: 99%

Filtration Shell Mediated Power Density Independent Orthogonal Excitations–Emissions Upconversion Luminescence

Guo

Zhao

et al. 2016

Angewandte Chemie

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“…Therefore, great efforts have been made to convert the excitation light of UCNPs to a shorter wavelength range in medical spectral window (e.g., 700-900 nm). Recently, Nd 3+ -doped UCNPs with ~800 nm excitation have been investigated to minimize the undesirable overheating effect 140-143. By taking this promising advantage, Xing and co-workers recently presented a unique tumor environment responsive UCNPs nanoplatform with the surface modified by enzyme sensitive peptide (Figure 7C) 144.…”

Section: Near-infrared (Nir) Light-mediated Theranosticsmentioning

confidence: 99%

Recent Advances of Light-Mediated Theranostics

Ai¹,

Mu²,

Xing³

2016

Theranostics

189

121

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Currently, precision theranostics have been extensively demanded for the effective treatment of various human diseases. Currently, efficient therapy at the targeted disease areas still remains challenging since most available drug molecules lack of selectivity to the pathological sites. Among different approaches, light-mediated therapeutic strategy has recently emerged as a promising and powerful tool to precisely control the activation of therapeutic reagents and imaging probes in vitro and in vivo, mostly attributed to its unique properties including minimally invasive capability and highly spatiotemporal resolution. Although it has achieved initial success, the conventional strategies for light-mediated theranostics are mostly based on the light with short wavelength (e.g., UV or visible light), which may usually suffer from several undesired drawbacks, such as limited tissue penetration depth, unavoidable light absorption/scattering and potential phototoxicity to healthy tissues, etc. Therefore, a near-infrared (NIR) light-mediated approach on the basis of long-wavelength light (700-1000 nm) irradiation, which displays deep-tissue penetration, minimized photo-damage and low autofluoresence in living systems, has been proposed as an inspiring alternative for precisely phototherapeutic applications in the last decades. Despite numerous NIR light-responsive molecules have been currently proposed for clinical applications, several inherent drawbacks, such as troublesome synthetic procedures, low water solubility and limited accumulation abilities in targeted areas, heavily restrict their applications in deep-tissue therapeutic and imaging studies. Thanks to the amazing properties of several nanomaterials with large extinction coefficient in the NIR region, the construction of NIR light responsive nanoplatforms with multifunctions have become promising approaches for deep-seated diseases diagnosis and therapy. In this review, we summarized various light-triggered theranostic strategies and introduced their great advances in biomedical applications in recent years. Moreover, some other promising light-assisted techniques, such as photoacoustic and Cerenkov radiation, were also systemically discussed. Finally, the potential challenges and future perspectives for light-mediated deep-tissue diagnosis and therapeutics were proposed.

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“…In cascade sensitization UCNPs, efficient upconversion luminescence can be achieved by light irradiation at both 980 nm and 808 nm . By combining direct sensitization upconversion and cascade sensitization upconversion in core‐shell architectures, an orthogonal upconversion emission can be achieved in response to two distinct NIR excitation wavelengths . Such UCNPs offer new opportunities for developing advanced drug delivery systems that are capable of sequentially delivering bioimaging and sensing, and therapeutic modalities.…”

Section: Excitation Manipulation Of Upconversion Nanoparticlesmentioning

confidence: 99%

Photon Upconversion Kinetic Nanosystems and Their Optical Response

Liu

Huang

Valiev

et al. 2017

Laser & Photonics Reviews

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Lanthanide-doped photon upconversion nanoparticles (UCNPs) are capable of converting low-intensity near-infrared light to UV and visible emission through the synergistic effects of light excitation and mutual interactions between doped ions. UCNPs have attracted strong interest as unique spectrum converters and found a multitude of applications in areas like biomedical imaging, energy harvesting and information technology. UCNPs are distinct from many other types of luminescent materials in terms of the involvement of a host lattice and multiple optical centers, i.e., trivalent lanthanide ions with manyfolds of accessible long-lived energy states, in individual nanoparticles. The mutual interactions between these optical centers, i.e., sequential energy transfers, make them operate as an integrated unit and co-determine the luminescence kinetics and other optical properties of the individual nanoparticle. Thus, each nanoparticle consititutes a kinetic optical system. In this work, we explore UCNPs from the outset of being such kinetic optical systems and review their physical formation, the underlying photophysics, macroscopic statistical description, and their response to various optical stimuli in the spectral, polarization, intensity, temporal and frequency domains, and demonstrate ways that their optical output can be optimized by manipulating the excitation schemes. Our review highlights upconversion nanotechnology as an interdisciplinary field across chemistry, physics and biomedical engineering, with great future possibilities, flexibility and ramifications. We outline some of the potential directions of upconversion nanoparticle research.

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An Upconversion Nanoparticle with Orthogonal Emissions Using Dual NIR Excitations for Controlled Two‐Way Photoswitching

Cited by 143 publications

References 66 publications

Filtration Shell Mediated Power Density Independent Orthogonal Excitations–Emissions Upconversion Luminescence

Filtration Shell Mediated Power Density Independent Orthogonal Excitations–Emissions Upconversion Luminescence

Recent Advances of Light-Mediated Theranostics

Photon Upconversion Kinetic Nanosystems and Their Optical Response

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