An update for the controversies and hypotheses of regulating nonthyroidal illness syndrome in chronic kidney diseases

Xu, Gaosi; Yan, Wenjun; Li, Jingzhen

doi:10.1007/s10157-014-0974-1

Cited by 33 publications

(19 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…28 The application of anti-oxidants for therapeutic intervention in patients with CKD may prove beneficial, but whether or not several anti-oxidants as a multi-drug therapy to target oxidant modifying pathways during the development of CKD remain unclear. [29][30][31][32] In conclusion, our present study indicated that inflammation and oxidative stress interacted with each other and played pivotal roles in the development of CKD. Variation in eGFR was parallel with the changes of oxidative stress and inflammation when CKD developing.…”

Section: Discussionmentioning

confidence: 90%

The progress of inflammation and oxidative stress in patients with chronic kidney disease

Luo

Liu

et al. 2014

Renal Failure

Self Cite

View full text Add to dashboard Cite

Background: The variations and their correlation of inflammation and oxidative stress in chronic kidney disease (CKD) have not been thoroughly understood. Materials and methods: Biomarkers of inflammation and oxidative stress were measured in a cohort of 176 patients with CKD ranging from stage 1 to 5 and 67 healthy controls. Correlation analysis in levels between inflammation and oxidative stress was also performed with estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease (MDRD) formula. Concentrations of serum creatinine (Scr), hs-CRP (hypersensitive C reactive protein) and MDA (malondialdehyde) of these participants were measured again after 12 month follow-up. Results: In the present study, with the development of CKD, serum levels of hs-CRP, interleukin-6 (IL-6) and MDA were significantly increased, and the serum levels of SOD (superoxide dismutase) and GSH-PX (glutathione peroxidase) were significantly decreased in these participants. eGFR was inversely associated with MDA and positively with SOD and GSH-PX when adjusting for age and hypertension therapy. IL-6 and hs-CRP were positively correlated with MDA, and negatively associated with SOD and GSH-PX. Notably, after 12-month follow-up, the increase in Scr was positively associated with the increase in hs-CRP (p50.01) and MDA (p50.05), respectively. Conclusions: Inflammation and oxidative stress interacted with each other and played pivotal roles in the development of CKD. Variation in eGFR was parallel with the changes of oxidative stress and inflammation when CKD developing.

show abstract

Section: Discussionmentioning

confidence: 90%

The progress of inflammation and oxidative stress in patients with chronic kidney disease

Luo

Liu

et al. 2014

Renal Failure

Self Cite

View full text Add to dashboard Cite

show abstract

“…A recent study demonstrated that the accumulated uremic toxins inhibited the enzyme activity of DIO1. 2 The progression of chronic kidney disease (CKD) is closely linked to oxidative stress 3,4 and chronic inflammation. 5 By activating nuclear factor kappa B (NF-kB) signaling pathway, stimulating the release of proinflammatory cytokines and inducing expression of monocyte chemoattractant protein, 6 oxidative stress promotes inflammation in ESRD.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant therapy improves non-thyroidal illness syndrome in uremic rats

Yang

2016

Renal Failure

Self Cite

View full text Add to dashboard Cite

Background The roles of antioxidant therapy on non-thyroidal illness syndrome (NTIS) in uremic rats is still unclear. Materials and methods Twenty-four Sprague-Dawley (SD) rats were randomly divided into blank, 5/6 nephrectomy (Nx), pyrrolidine dithiocarbamate (PDTC, 10 mg/100 g), sodium bicarbonate (SB, 0.1 g/100 g), N-acetylcysteine (NAC, 80 mg/100 g) and thyroid hormones (TH, levothyroxine 2 mg/100 g) groups. The serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), advanced oxidation protein products (AOPP), interleukin (IL)-1b, free triiodothyronine (FT3), and thyroid stimulating hormone (TSH) were detected in the sixth week. The expressions of IL-1b and deiodinase type 1 (DIO1) were assessed by western blotting. The nuclear factor kappa B (NF-kB) inflammatory signal pathway was confirmed by electrophoretic mobility shift assay (EMSA). Results Compared with 5/6 Nx group, PDTC and NAC significantly reduced the levels (p50.01, respectively) of serum MDA, AOPP, TSH, and elevated levels of serum SOD (p50.01, respectively) and FT3 (p ¼ 0.016 and p50.01). Neither had significant effects on serum IL-1b content (p ¼ 0.612 and p ¼ 0.582). PDTC and NAC markedly decreased the protein expression of IL-1b (p50.01) and increased the protein expression of DIO1 (p50.01), respectively. Both had been considerably blunted NF-kB activity (p50.01). Conclusions In uremic rat model, PDTC and NAC can effectively improve oxidative stress level and NTIS. In terms of improving oxidative stress level, NAC is probably superior to PDTC.

show abstract

“…in which low T3 and normal T4 levels are observed). This could imply that CFS is a chronic disease (27,28).…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine disorder in chronic fatigue syndrome

Tomić¹,

Brkić²,

Lendak³

et al. 2017

Turk J Med Sci

View full text Add to dashboard Cite

Background/aim: Neuroendocrine disorders are considered a possible pathogenetic mechanism in chronic fatigue syndrome (CFS). The aim of our study was to determine the function of the hypothalamic-pituitary-adrenal axis (HPA) and thyroid function in women of reproductive age suffering from CFS. Materials and methods:The study included 40 women suffering from CFS and 40 healthy women (15-45 years old). Serum levels of cortisol (0800 and 1800 hours), ACTH, total T4, total T3, and TSH were measured in all subjects. The Fibro Fatigue Scale was used for determination of fatigue level.Results: Cortisol serum levels were normal in both groups. The distinctively positive moderate correlation of morning and afternoon cortisol levels that was observed in healthy women was absent in the CFS group. This may indicate a disturbed physiological rhythm of cortisol secretion. Although basal serum T4, T3, and TSH levels were normal in all subjects, concentrations of T3 were significantly lower in the CFS group. Conclusion:One-time hormone measurement is not sufficient to detect hormonal imbalance in women suffering from CFS. Absence of a correlation between afternoon and morning cortisol level could be a more representative factor for detecting HPA axis disturbance.

show abstract

An update for the controversies and hypotheses of regulating nonthyroidal illness syndrome in chronic kidney diseases

Cited by 33 publications

References 67 publications

The progress of inflammation and oxidative stress in patients with chronic kidney disease

The progress of inflammation and oxidative stress in patients with chronic kidney disease

Antioxidant therapy improves non-thyroidal illness syndrome in uremic rats

Neuroendocrine disorder in chronic fatigue syndrome

Contact Info

Product

Resources

About