An update in international trends in incidence rates of thyroid cancer, 1973–2007

James, Benjamin C.; Mitchell, Joshua R.; Jeon, Heedo D.; Vasilottos, Nektarios; Grogan, Raymon H.; Aschebrook‐Kilfoy, Briseis

doi:10.1007/s10552-018-1023-2

Cited by 81 publications

(60 citation statements)

References 21 publications

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“…This international comparison confirms the very high TC incidence rates in some — but not all — HICs in 2008–2012 and shows very high incidence rates in several LMICs, particularly in urban areas. Besides, the proportion of papillary carcinomas — the histological type making up the bulk of the increase in and overdiagnoses of TC in several countries — is similar in the HICs and LMICs with the highest incidence rates. Together with the uniformly low mortality rates, these findings support the existence of overdiagnosis of TC cases in LMICs.…”

Section: Discussionmentioning

confidence: 97%

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Thyroid cancer “epidemic” also occurs in low‐ and middle‐income countries

Lortet‐Tieulent

Franceschi

Maso

et al. 2018

Intl Journal of Cancer

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Thyroid cancer incidence varies greatly between and within high‐income countries (HICs), and overdiagnosis likely plays a major role in these differences. Yet, little is known about the situation in low‐ and middle‐income countries (LMICs). We compare up‐to‐date thyroid cancer incidence and mortality at national and subnational levels. 599,851 thyroid cancer cases in subjects aged 20–74 reported in Cancer Incidence in Five Continents volume XI from 55 countries with at least 0.5 million population, aged 20–74 years, covered by population‐based cancer registration, and 22,179 deaths from the WHO Mortality Database for 36 of the selected countries, over 2008–2012, were included. Age‐standardized rates were computed. National incidence rates varied 50‐fold. Rates were 4 times higher among women than men, with similar patterns between countries. The highest rates (>25 cases per 100,000 women) were observed in the Republic of Korea, Israel, Canada, the United States, Italy, France, and LMICs such as Turkey, Costa Rica, Brazil, and Ecuador. Incidence rates were low (<8) in a few HICs (the Netherlands, the United Kingdom, and Denmark) and lowest (3–4) in some LMICs (such as Uganda and India). Within‐country incidence rates varied up to 45‐fold, with the largest differences recorded between rural and urban areas in Canada (HIC) and Brazil, India, and China (LMICs). National mortality rates were very low (<2) in all countries and in both sexes, and highest in LMICs. The very high thyroid cancer incidence and low mortality rates in some LMICs also strongly suggest a major role of overdiagnosis in these countries.

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Section: Discussionmentioning

confidence: 97%

“…The incidence of thyroid cancer (TC) has been increasing markedly in several high‐income countries (HICs), including France, Italy, and the United States, since the 1980s, and in the Republic of Korea since the mid‐1990s . In contrast, TC mortality has remained low and stable, or has even declined .…”

Section: Introductionmentioning

confidence: 99%

Thyroid cancer “epidemic” also occurs in low‐ and middle‐income countries

Lortet‐Tieulent

Franceschi

Maso

et al. 2018

Intl Journal of Cancer

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“…ere is a high prevalence of papillary thyroid carcinoma worldwide with an increasing incidence attributed to the increased diagnosis of papillary thyroid microcarcinoma (PTMC) [1,2]. PTMC are tumors less than or equal to 10 mm along the greatest diameter [3] and are most often incidentally identified during routine thyroid ultrasonography [4,5] with the major risk factors being a positive family history and exposure to ionising radiation [6].…”

Section: Introductionmentioning

confidence: 99%

Lymph Node Metastasis and Extrathyroidal Extension in Papillary Thyroid Microcarcinoma in Cyprus: Suspicious Subcentimeter Nodules Should Undergo FNA When Multifocality is Suspected

Papaioannou

Lamnisos

Kyriacou³

et al. 2020

Journal of Thyroid Research

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Objective. To determine the prevalence of lymph node (LN) metastasis and extrathyroidal extension (ETE) in patients with papillary thyroid microcarcinoma (PTMC) in Cyprus and to evaluate the role of preoperative ultrasound (U/S) examination. Methods. A retrospective study of 102 patients who underwent thyroidectomy for PTMC in a 2-year period. Preoperatively, all patients had a thyroid and neck U/S examination with LN mapping. Tumor size according to the largest diameter, number of foci, LN metastasis, and ETE data was collected from the histopathological report and was compared to the preoperative U/S reports. Results. LN metastasis was present in 23.5% of patients. 15.7% had central, 3.9% had lateral, and 3.9% had both central and lateral LN metastasis. ETE was present in 27.5% of patients. 21.6% had multifocal disease, and in this group, 40.9% had LN metastasis and 36.4% had ETE. Multifocality (p=0.03), size of tumor (p=0.05), and ETE (p≤0.001) were significantly associated with LN metastasis. The prevalence of LN metastasis in multifocal PTMC ≤5 mm was the same with multifocal PTMC >5 mm. The preoperative U/S sensitivity for the suspicious lateral neck and central LN was 100%, and the specificity was 100%. The preoperative U/S sensitivity for nodules suspicious for ETE was 53.6%, and the specificity was 100%. Conclusion. The presence of LN metastasis and ETE in our PTMC patients in Cyprus is frequent. Neck U/S mapping is a highly reliable and accurate tool in identifying metastatic nodes. LN metastasis is associated with ETE and multifocality. Suspicious subcentimeter nodules should undergo FNA irrespective of size when multifocality is suspected.

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“…Women are more susceptible to thyroid gland diseases than men. Both benign and malignant thyroid tumors are 3-4 times more likely to develop in women than in men 1,2 . The autoimmune diseases of the thyroid gland have also a higher prevalence in women than in men 3,4 .…”

Section: Introductionmentioning

confidence: 99%

The experimental study of the pathogenic role of NADPH-oxidase in the thyroid gland tissues

Bagmut¹,

Galmiz²,

Gramatiuk³

et al. 2019

Arch Balk Med Union

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Étude expérimentale du rôle pathogénique de la NADPH-oxydase dans les tissus de la glande thyroïde L'objectif de l'étude était de comparer le système NADPH / H2O2 et l'expression des enzymes, dans la culture de cellules de la glande thyroïde, en fonction du sexe. Méthodes. La glande thyroïde a été prélevée chez des donneuses adultes (n = 20) et des hommes (n = 15). Les cellules ont été lavées deux fois avec du HBSS et centrifugées à 1000 xg pendant 5 minutes, puis cultivées à 106 cellules dans 0,5 ml de milieu de culture par puits dans des plaques à 24 puits (Thermo Fisher Scientific, USA). Les niveaux de H2O2 dans les cellules ont été déterminés de manière quantitative à l'aide d'un capteur de peroxyde d'hydrogène Premo ™ Orp1-roGFP (Life Technologies, USA) conformément aux instructions du fabricant. L'analyse statistique des résultats a été réalisée avec Statistica 6.1 (StatSoft, Inc., USA). Résultats. Nous avons constaté que l'expression de DUOX1 et de NOX4 était significativement plus élevée chez les femmes par rapport aux hommes (1,5 fois, p <0,05). L'expression de DUOX2 dans les cellules femelles était 1,5 fois plus élevée que celle des hommes mais statistiquement significative (p = 0,06). Nous

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An update in international trends in incidence rates of thyroid cancer, 1973–2007

Abstract: Our analysis of the published CI5 data illustrates that the incidence of thyroid cancer increased between 1998-2002 and 2003-2007 in most populations worldwide, and rising rates continue in all regions of the world.

Cited by 81 publications

References 21 publications

Thyroid cancer “epidemic” also occurs in low‐ and middle‐income countries

Thyroid cancer “epidemic” also occurs in low‐ and middle‐income countries

Lymph Node Metastasis and Extrathyroidal Extension in Papillary Thyroid Microcarcinoma in Cyprus: Suspicious Subcentimeter Nodules Should Undergo FNA When Multifocality is Suspected

The experimental study of the pathogenic role of NADPH-oxidase in the thyroid gland tissues

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