An Update of Gorlin-Goltz Syndrome

Hasan, Aliya; Akintola, Dapo

doi:10.1177/205016841800700306

Cited by 17 publications

(10 citation statements)

References 15 publications

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“…In our case, the initial manifestations were odontogenic keratocysts and basal cell carcinomas. This reiterates the importance of dental professionals to know the clinical manifestations of conditions that involve not only the oral cavity, but also the whole individual (MacDonald, 2015;Figueira et al;Hasan & Akintola).…”

Section: Discussionmentioning

confidence: 90%

“…Multiple odontogenic keratocysts affect 75-100 % of people with Gorlin-Goltz syndrome, and may be the first sign of this genetic disorder. Although histologically they are similar to nonsyndromic cases, they present a more aggressive behavior (Morgan et al, 2005;Pogrel, 2015;Hasan & Akintola). Therefore, in multiple odontogenic cysts occurrence, the GGS hypothesis must be investigated (Titinchi et al; Antonoglou et al).…”

Section: Discussionmentioning

confidence: 99%

“…It was later modified by Rayner and colleagues, who added other skeletal anomalies, such as cerebral phalanx calcification and palmar lumps (Rayner et al, 1976;Figueira et al). This disorder can exhibit several clinical signs and symptoms, and in addition to the characteristics already mentioned, other clinical alterations seen are: prognathic jaws, cleft lip and palate, impacted teeth, dental agenesis (Titinchi et al), epidermoid cysts (Baliga & Rao, 2010) and other rare abnormalities, such as the development of ovarian fibroids in women (Evans et al, 1993;Shanley et al, 1994;Hasan & Akintola, 2018) and formation of other neoplasms, such as medulloblastoma and non-Hodgkin's lymphomas (Shanley et al; Hasan & Akintola).…”

Section: Introductionmentioning

confidence: 99%

“…The GGS's prevalence varies according to the country where the study was conducted, but it has an average incidence of 1 in 50,000 to 150,000 for the general population (Khaliq et al; Nilius et al). The forms of treatment are varied, but they must include the removal of basal cell nevus carcinomas (surgically or not) (Palacios-Álvarez et al, 2018) and keratocysts, ranging from conservative approaches (such as marsupialization / decompression associated or not with enucleation), or radical, with resection (Antonoglou et al;Khaliq et al;Ribeiro-Júnior et al, 2017;Hasan & Akintola).…”

Section: Introductionmentioning

confidence: 99%

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Gorlin-Goltz Syndrome: The importance of Clinical Investigation and a Multidisciplinary Approach

Bachesk

Péder

Lustosa

et al. 2021

Int. J. Odontostomat.

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Gorlin-Goltz Syndrome is a genetic disorder characterized by a series of clinical changes, including the presence of multiple odontogenic keratocysts and nevus basal cell carcinomas. As these lesions involve the maxillofacial region and can evolve to severe sequelae, it is essential that the dental surgeon recognize this pathology, in order to promote a correct investigation and early multidisciplinary diagnosis and treatment. The treatment for the cysts varies according to the lesion's characteristics and location, and therefore, the request for complementary exams is essential. According to literature, the approach varies from conservative to more invasive, and several supporting therapies are mentioned. Thus, this article aims to report a case of a young patient diagnosed with Gorlin-Goltz Syndrome by a dental surgeon, who treated conservatively and interdisciplinarly, and obtained a satisfactory result. In addition, it makes a bibliographic review on this genetic condition, elucidating its therapeutic forms.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gorlin-Goltz Syndrome: The importance of Clinical Investigation and a Multidisciplinary Approach

Bachesk

Péder

Lustosa

et al. 2021

Int. J. Odontostomat.

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“…In light of the risk of malignancy, it is important to be aware of this syndrome and recognize the need for early referral for multidisciplinary management. 31 Diagnosis of this syndrome by dentist is of utmost importance as the appearance of keratocytes with a dental origin may be the initial sign of this syndrome.…”

Section: Discussionmentioning

confidence: 99%

Genetic Implication and Dental Consideration in Syndromes with Benign and Malignant Oral Neoplastic Component: A Narrative Review

Singh

Gupta

Pendalya

et al. 2019

Journal of Advanced Oral Research

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Background and Objective: The presence of an internal and often occult malignancy may be forewarned by various oral manifestations. Several of these findings are preferentially localized to the head and neck region, including the oral cavity. This places the dental practitioner in a unique position to detect these signs and symptoms of occult neoplastic involvement. Because they may be present before an established syndrome or cancer diagnosis, even representing the initial expression of disease in some cases, early recognition by a dentist may lead to timely diagnosis and management of these syndromes. Thus, the aim of this narrative review was literature search and gathering data of such syndromes. Materials and Methods: A Medline–PubMed search was conducted of the literature using the keywords “syndrome,” “dental management,” “Cowden’s syndrome,” “Peutz–Jeghers syndrome,” “malignant component,” “Gardner’s syndrome,” “Gorlin–Goltz syndrome,” and “McCune–Albright syndrome.” The search strategy was limited to human studies (case reports and case series), full-text English articles published from January 1, 2000, to mid-2019. Irrelevant articles or articles with inadequate information were omitted. Results: A total of 36 pieces of literature were reviewed, of which 13 were literature reviews, 15 case reports, 3 expert committee guides and updates, and 4 original research papers, and 1 was a book. Conclusion: These syndromes pose risk during dental practice, which necessitates extra awareness and caution to prevent potential complications. Although, the multidisciplinary approach in treating these cases is not well documented, any related information may be helpful in understanding the pathogenesis and the nature of these syndromes.

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Gorlin-Goltz Syndrome (Nevoid Basal Cell Carcinoma Syndrome)

Panteliadis

Friedrich

2022

Neurocutaneous Disorders

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An Update of Gorlin-Goltz Syndrome

Cited by 17 publications

References 15 publications

Gorlin-Goltz Syndrome: The importance of Clinical Investigation and a Multidisciplinary Approach

Gorlin-Goltz Syndrome: The importance of Clinical Investigation and a Multidisciplinary Approach

Genetic Implication and Dental Consideration in Syndromes with Benign and Malignant Oral Neoplastic Component: A Narrative Review

Gorlin-Goltz Syndrome (Nevoid Basal Cell Carcinoma Syndrome)

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