An update on biomaterials as microneedle matrixes for biomedical applications

Abstract

MNs have been developed for various applications such as drug delivery, cosmetic, diagnosis and biosensing. To meet the requirements of MNs used in these areas, numerous materials have been used...

Intradermal delivery of an angiotensin II receptor blocker using a personalized microneedle patch for treatment of hypertrophic scars

“…Microneedles (MNs) represent a novel technology for drug delivery. [6][7][8] With micrometer-scaled needles arranged in a designed patch, the microneedle patch system has advantages such as minimal invasion and personalized and precise drug release and has attracted emerging attention in biosensing, 9,10 diagnosis, 11 and treatments of different diseases including diabetes, [12][13][14] cancers, 15,16 wounds, [17][18][19] scars, [20][21][22] and psoriasis. 23 The stratum corneum is the main barrier of the skin and limits the efficiency of transdermal drug penetration.…”

Microneedles for in situ tissue regeneration

“…And MNs prepared from synthetic polymers such as PLGA and PLA typically have higher mechanical properties and slower drug release rates. The materials commonly used for the preparation of dissolving MNs and their advantages and disadvantages can be found in the published reviews [ 36 , 63 ].…”

“…And MNs can also extract tissue interstitial fluid to obtain disease-related biomarkers [ [29] , [30] , [31] ]. As a result, MNs have been widely used to treat and detect various diseases, including skin cancer, infections, diabetes, obesity, and ocular diseases [ [32] , [33] , [34] , [35] , [36] , [37] , [38] ]. In the field of regenerative medicine, there are two main application pathways of MNs.…”

Versatile Metalloporphyrin‐Based Electrochemical Sensing Applications: From Small Gasotransmitters to Macromolecules

“…Dopamine (DA) is an important neurotransmitter, and an abnormal concentration may be related to neurological problems such as schizophrenia and Parkinson's disease [167] . Sensors sensitive to DA in the order of nM−M have been reported using porphyrin nanocomposites with Fe (on TaWO 6 [155] or poly sodium‐ p ‐styrene sulfonate modified graphene), [168] Mn and Cu (on reduced graphene oxide), [169] among others. Recently, Zheng and co‐workers [156] have demonstrated the improvement by incorporating two metals in porphyrin metal‐organic framework systems over monometallic systems.…”