An update on chemical eye burns

Bizrah, Mukhtar; Yusuf, Ammar; Ahmad, Sajjad

doi:10.1038/s41433-019-0456-5

Cited by 106 publications

(77 citation statements)

References 101 publications

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“…Men aged 18-64 years [4,10] and children aged 1-2 years [7,15] might be at the highest risk for ocular chemical injury in the workplace or residential locations due to occupational exposure and topical personal products and cleaning agents. In our study, the majority of the patients were factory workers and construction workers, which was in agreement with the findings of Bizrah and co-workers [16]: most ocular chemical injuries were work-related. Although the delay in the presentation of 133 (83.1%) patients for medical treatment was less than 24 h after injury, only 64 (40.0%) patients were at the consultation room in less than 3 h. Bizrah et al [14] also found that 87% of patients presented to the Moorfields Eye Hospital emergency department within 24 h, but they did not state the numbers of patients in more detailed time window (e.g., less than 3 h, within 3-6 h, within 6-12 h).…”

Section: Discussionsupporting

confidence: 93%

Clinical characteristics of patients hospitalized for ocular chemical injuries in Shanghai from 2012 to 2017

Jiang

Zhou

2020

Int Ophthalmol

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Purpose To summarize the clinical characteristics of patients with ocular chemical injuries and evaluate their potential relationship with the visual outcome by analyzing the medical records of these patients from January 1, 2012, to December 31, 2017. Methods This is a retrospective case series study. Patient data included age, gender, occupational classification, location of ocular chemical injury, initial and final best-corrected distance visual acuity (BCDVA), intraocular pressure (IOP), nature and chemical phase, distribution and severity of chemical injury, management methods, and complications. All variables were evaluated for their potential relationship with visual outcome. Results A total of 160 patients were hospitalized with ocular chemical injuries. Majority of the patients were factory workers and arrived at the consultation room less than 24 h after injury. The most common ocular injury setting, classification of severity, causative chemical, chemical phase, and complications were workplace, grade II, unknown and mixed substance, liquid, and elevated IOP, respectively. The risk factors for poor final BCDVA were identified as older age, poor initial BCDVA, and irrigation 24 h after injury (P \ 0.001, P \ 0.001, and P = 0.011, respectively). Conclusions We elaborate the clinical characteristics and outcomes of patients with ocular chemical injuries in Jinshan District, Shanghai. A comprehensive education program should be established and the use of protective eyewear should be promoted to prevent occupation-related ocular chemical injuries.

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Section: Discussionsupporting

confidence: 93%

Clinical characteristics of patients hospitalized for ocular chemical injuries in Shanghai from 2012 to 2017

Jiang

Zhou

2020

Int Ophthalmol

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“…In these cases, it is difficult for the patient's visual function to recover. In nonmechanical ocular trauma due to the different injury mechanisms, the damage to the eye tissue is continuous, and patients are often blinded by long-term complications, such as corneal perforation, limbal stem cell deficiency, and secondary glaucoma [21].…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Visual Outcomes of Patients Hospitalized for Ocular Trauma in Shandong Province, China

Duan

Chen

Zhang

et al. 2020

Journal of Ophthalmology

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Purpose. To analyze the clinical characteristics and visual prognoses of patients with ocular trauma treated in Shandong Eye Hospital. Methods. The inpatient data of patients with eye injuries hospitalized in our institution from January 2014 to December 2018 were retrospectively reviewed, including demographic information, types of trauma, causes of injury, treatment, and initial and final visual acuities. Results. A total of 1,425 patients (1,622 eyes), aged 39.5 ± 18.5 years, were included. The ratio of male to female was 5.3 : 1. Of the mechanical eye injuries, there were 490 (34.4%) open-globe injuries and 454 (31.9%) closed-globe injuries. Nonmechanical eye injuries had 426 patients (29.9%), while 55 patients (3.9%) had adnexal injuries. Over a half of the traumas were work-related (51.1%, 728 patients). Most patients were treated with surgical intervention (1,404 eyes, 87.9%). There were significant differences in the final visual acuities between open-globe injuries and closed-globe injuries (P<0.001), as well as between mechanical injuries and nonmechanical injuries (P<0.001). The final visual acuity was closely correlated with the initial visual acuity (Spearman’s correlation coefficient = 0.618, P<0.001) and the OTS score (Spearman’s correlation coefficient = 0.691, P<0.001). Conclusion. Ocular trauma usually occurs in young and middle-aged men and in the workplace in Shandong Province. The proportion of nonmechanical injuries is high, and the prognosis is poor. A comprehensive understanding of the characteristics of ocular trauma is useful for blindness prevention and treatment.

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“…Epithelial scraped mouse models were used to further investigate in vivo the benefits of hypothermically stored Ad-MSC bandages. It has been shown that Ad-MSCs can promote wound healing in various animal models using different approaches [ 38 , 81 , 82 ]. Our data show a reduction in corneal haze with an improvement in corneal healing shown by H&E staining.…”

Section: Discussionmentioning

confidence: 99%

Hypothermically Stored Adipose-Derived Mesenchymal Stromal Cell Alginate Bandages Facilitate Use of Paracrine Molecules for Corneal Wound Healing

Al-Jaibaji

Swioklo

Shortt³

et al. 2020

IJMS

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Adipose-derived mesenchymal stromal cells (Ad-MSCs) may alleviate corneal injury through the secretion of therapeutic factors delivered at the injury site. We aimed to investigate the therapeutic factors secreted from hypothermically stored, alginate-encapsulated Ad-MSCs’ bandages in in vitro and in vivo corneal wounds. Ad-MSCs were encapsulated in 1.2% w/v alginate gels to form bandages and stored at 15 °C for 72 h before assessing cell viability and co-culture with corneal scratch wounds. Genes of interest, including HGF, TSG-6, and IGF were identified by qPCR and a human cytokine array kit used to profile the therapeutic factors secreted. In vivo, bandages were applied to adult male mice corneas following epithelial debridement. Bandages were shown to maintain Ad-MSCs viability during storage and able to indirectly improve corneal wound healing in vivo. Soluble protein concentration and paracrine factors such as TSG-6, HGF, IL-8, and MCP-1 release were greatest following hypothermic storage. In vivo, Ad-MSCs bandages-treated groups reduced immune cell infiltration when compared to untreated groups. In conclusion, bandages were shown to maintain Ad-MSCs ability to produce a cocktail of key therapeutic factors following storage and that these soluble factors can improve in vitro and in vivo corneal wound healing.

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An update on chemical eye burns

Cited by 106 publications

References 101 publications

Clinical characteristics of patients hospitalized for ocular chemical injuries in Shanghai from 2012 to 2017

Clinical characteristics of patients hospitalized for ocular chemical injuries in Shanghai from 2012 to 2017

Clinical Characteristics and Visual Outcomes of Patients Hospitalized for Ocular Trauma in Shandong Province, China

Hypothermically Stored Adipose-Derived Mesenchymal Stromal Cell Alginate Bandages Facilitate Use of Paracrine Molecules for Corneal Wound Healing

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