An update on dietary consideration in inflammatory bowel disease: anthocyanins and more

Abstract

Inflammatory bowel disease (IBD) is a chronic idiopathic inflammatory disorder. A wealth of data pointed out that various aspects of chronic inflammation may be affected by several specific dietary factors. This paper calls attention to anthocyanins enriched plant food and anthocyanin dietary supplements, whose role in the management of IBD and its associated oncogenesis deems crucial. Area covered: We updated the most relevant dietary anthocyanins with potential anti-colitis and preventive effect on inflammatory associated colorectal cancer based on the recent animal and human researches along with revealing the major cellular and molecular mechanisms of action. Mounting evidence reported that anthocyanins enriched plant foods perform their protective role on IBD and inflammatory-induced colorectal cancer via different cellular transduction signaling pathways, including inflammatory transcription factors, SAPK/JNK and p38 MAPK cascade, JAK/STAT signaling, NF-kB/pERK/MAPK, Wnt signaling pathway, Nrf2 cytoprotective pathway as well as AMPK pathway and autophagy. Expert commentary: Combination of anthocyanins enriched dietary supplements with existing medications can provide new therapeutic options for IBD patients. Further, well-designed randomized control trials (RCTs) are essential to evaluate the role of anthocyanins enriched medicinal foods as well as isolated anthocyanin components as promising preventive and therapeutic dietary agents for IBD and its associated oncogenesis.

Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies

“…Delphinidin induced dose-(80-150 µM) and time-dependent autophagic vacuolization and induced the lipidated form of LC3 II in human HCC cell lines (SMMC7721, HCCLM3 and MHCC97L). In these cells, the inhibition of delphinidin-induced autophagy resulted in necrotic cell death, likely because of an ATP deficiency that prevented caspase activation and subsequent apoptosis [155]. Anthocyanidins (pelargonidin, cyanidin, malvidin, peonidin and delphinidin) (100 µM) induced autophagy in HeLa cervical cancer cells.…”

A Brief Review of Nutraceutical Ingredients in Gastrointestinal Disorders: Evidence and Suggestions

“…They are actually water-soluble pigments and abundant in diet like blueberry, raspberry, bilberry, black rice and black beans, etc. Anthocyanins were shown capable of inhibiting pro-inflammation molecules and pathways [32], which were considered contributing the anti-inflammatory effect and alleviation of tissue damage in UC patients [33]. As substantial trials are yet to be cast out in IBD or colon cancer patients, it is still inconclusive for deciding whether anthocyanins should be taken to benefit the disease.…”

Microbiota, hábitos alimentarios y dieta en enfermedad inflamatoria intestinal

“…Por ello el control nutricional en esta etapa se debe focalizar en evitar el deterioro nutricional y evaluar los beneficios reales de la modificación de la alimentación según la severidad de la crisis, para evitar restricciones mayores que no producen una mejora en la condición del paciente. Es necesario considerar aspectos de los alimentos tales como la composición de carbohidratos y su capacidad osmótica 35 , efecto proinflamatorio 36 , tipo de fibra, contenido de aditivos alimentarios 37 e impacto de compuestos específicos como las antocianinas 38 , para realizar una modificación dietética. Todo esto para generar un efecto en la disminución de la sintomatología y contribuir a disminuir la inflamación.…”

“…Antocianinas Las antocianinas, son un subgrupo de los flavonoides que son reconocidas por dar el intenso color azul, púrpura, rojo y naranja de muchas frutas y verduras 52 . En personas con EII los suplementos dietarios enriquecidos con antocianinas pueden tener un potencial efecto beneficioso en diminuir la inflamación 38 . Así es como la ingesta de extracto de arándano rico en antocianina es capaz de reducir las citoquinas proinflamatorias IFN-y y TNF-α en cultivo primario de biopsias de colon de pacientes con colitis ulcerosa activa 53 .…”