An Update on Drug-Induced Pigmentation

An unusual case of acquired facial pigmentation

“…Other causes of drug induced pigmentation include amiodarone, cytotoxic drugs (eg, bleomycin, cyclophosphamide), anticonvulsants (eg, phenytoin), and hydroxychloroquine. Paradoxically, prolonged use of topical hydroquinone, a skin bleaching agent, can also result in pigmentation, known as exogenous ochronosis 6…”

PrEPping for a healthier future – a concise update of current pharmacological HIV-prophylaxis practices

“…19 Nevertheless, this should be communicated, especially to non-Caucasian patients, who appear to have an increased risk. 19,20 Importantly, although comorbid hepatitis B (HBV) infection is not an absolute contraindication for PrEP initiation, 6 liver function should as far as possible be monitored as abrupt treatment cessation could result in hepatitis flare-ups. 18 Specialist referral should be encouraged in HBV-positive patients.…”

Tongue Hyperpigmentation Associated with Temozolomide as a Single Agent: Case Report

“…Drug-induced pigmentation accounts for up to 20% of all cases of acquired pigmentation. 1 Hyperpigmentation of the tongue has been associated with chemotherapy, specifically cytotoxic drugs, but the exact pathophysiological mechanism is still not well understood. 1 Temozolomide appears in the literature associated with tongue hyperpigmentation in combination therapy.…”