An update on hearing impairment in patients with rheumatoid arthritis

Emamifar, Amir; Hansen, Inger Marie Jensen

doi:10.1016/j.joto.2017.10.002

Cited by 9 publications

(9 citation statements)

References 12 publications

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“…These findings have significant clinical implications because this frequency range is the most important for speech processing 23 . Hearing loss within this frequency range has also been reported in other systemic autoimmune diseases, including RA, AS, and SLE 24,25,26,27,28 .…”

Section: Discussionmentioning

confidence: 64%

Association Between Psoriasis with Arthritis and Hearing Impairment in US Adults: Data from the National Health and Nutrition Examination Survey

Semenov

Hsiang²,

Huang³

et al. 2019

J Rheumatol

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Objective.Emerging data has linked inflammatory arthritis with hearing impairment (HI). The objective of this study was to investigate the relationship between psoriasis with arthritis (PsA) and HI in the US population. Given the known association of HI and depression, a secondary aim is to investigate the effect of PsA on mental well-being.Methods.Cross-sectional study using the National Health and Nutrition Examination Survey for adults aged ≥ 20 years (n = 10,747). Association of PsA with above outcomes was examined using multivariable generalized linear and ordinal logistic regression models, adjusted for demographics and medical comorbidities. Structural equation models examined the extent to which HI mediated the effect of PsA on mental health.Results.Individuals with PsA were more likely to report hearing difficulties (OR 1.50, p = 0.043), visit a mental health provider (OR 1.62, p = 0.084), have 1.62 more days of poor mental health over the previous month (p = 0.033), and have depression (OR 2.01, p = 0.015) compared to controls. HI mediated 6.5%, 8.3%, and 5.0% of the effect of PsA on the above mental health outcomes, respectively.Conclusion.PsA is independently associated with a significantly increased risk of HI, which partially mediates an association with worsened psychiatric outcomes.

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Section: Discussionmentioning

confidence: 64%

Association Between Psoriasis with Arthritis and Hearing Impairment in US Adults: Data from the National Health and Nutrition Examination Survey

Semenov

Hsiang²,

Huang³

et al. 2019

J Rheumatol

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“…However, RA is known to have extra-articular manifestations (EAMs) involving the lungs, heart, eyes, skin, ears, and other body structures. Sensorineural hearing loss (SNHL) is the most prevalent form of hearing impairment in rheumatoid arthritis, with a prevalence rate between 12% and 80% [ 4 ]. Studies have reported that SNHL affects high frequency, although middle and low frequencies have also been seen [ 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Other etiologies have been linked to drugs such as salicylates, non-steroidal anti-inflammatory drugs, and disease-modifying antirheumatic drugs. More so, environmental factors, such as smoking, alcohol, and exposure to noise, have been shown to affect the auditory system in healthy individuals and patients with RA [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Sudden-Onset Sensorineural Hearing Loss and Tinnitus in a Patient With Rheumatoid Arthritis: A Case Report and Literature Review

Torere¹,

Chittipolu²,

Alugba³

et al. 2023

Cureus

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Rheumatoid arthritis (RA) can affect the auditory system either as a direct complication of the disease course or secondary to medication adverse effects. Rheumatoid arthritis-induced autoimmune inner ear disease can present as tinnitus, conductive hearing loss, sensorineural hearing loss (SNHL), or mixed. According to previously published articles, SNHL is the most common hearing loss in RA. Age, smoking, noise exposure, and alcohol may affect the disease progression. Here, we present a case of a 79-year-old female who presented to the rheumatology clinic with complaints of abrupt onset bilateral hearing loss with associated tinnitus; pure tone audiometry confirmed sensorineural hearing loss. Her tinnitus resolved completely, and her hearing improved significantly after treatment with steroids and leflunomide. Based on this case and previous literature, we conclude that rheumatoid arthritis is the cause of SNHL in our patient. Appropriate and timely medical interventions have been reported to improve the prognosis of hearing impairment in rheumatoid arthritis patients. Our case highlights the need to have a high index of suspicion of rheumatoid arthritis-induced autoimmune inner ear disease in an elderly patient presenting with sudden-onset hearing impairment and the importance of prompt referral to a rheumatologist.

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“…While hearing impairment has been reported to occur in up to 60% of patients with RA, its pathogenesis is not clear [ 11 ]. Sensorineural hearing loss was the most common hearing impairment, occurring in up to 80% of cases, following by conductive hearing loss [ 13 , 15 ]. While conductive hearing loss can be caused by arthritis of the incudostapedial and incudomalleolar joints, sensorineural hearing loss can be associated with inflammation of the inner ear, as well as vasculitis, neuritis, or deposition of immune complex, which result in cochlear damage [ 15 - 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…Sensorineural hearing loss was the most common hearing impairment, occurring in up to 80% of cases, following by conductive hearing loss [ 13 , 15 ]. While conductive hearing loss can be caused by arthritis of the incudostapedial and incudomalleolar joints, sensorineural hearing loss can be associated with inflammation of the inner ear, as well as vasculitis, neuritis, or deposition of immune complex, which result in cochlear damage [ 15 - 18 ]. The risk factors for hearing impairment in RA include old age, male, long disease duration, and anti-citrullinated peptide antibody (ACPA) positivity [ 13 - 15 ].…”

Section: Introductionmentioning

confidence: 99%

Idiopathic Inflammatory Arthritis in the Auditory Canal in a Patient With Hearing Impairment: A Case Report and Literature Review

2022

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Inflammatory arthritis can affect the auditory system during the disease course. Although most cases show asymptomatic hearing impairment, it can result in hearing loss. Here we describe the case of a 70-year-old female with hearing impairment associated with idiopathic inflammatory arthritis in her auditory system. She had suffered from hearing difficulties for decades; however, the causes of her hearing impairment had not been evaluated. Pure tone audiometry showed severe sensorineural hearing loss requiring a cochlear implant. The workup for the cochlear implant revealed erosive changes in the incudomalleolar and incudostapedial joints with soft tissue swelling on temporal bone computed tomography. Bone pathology revealed plasmacytic infiltration and granulomatous inflammation. Laboratory examinations showed elevated levels of inflammatory markers; otherwise, she had negative results for all autoantibodies. In patients with idiopathic hearing loss, inflammatory arthritis of the middle ear without peripheral arthritis can provide a clue regarding the cause of the hearing loss.

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An update on hearing impairment in patients with rheumatoid arthritis

Cited by 9 publications

References 12 publications

Association Between Psoriasis with Arthritis and Hearing Impairment in US Adults: Data from the National Health and Nutrition Examination Survey

Association Between Psoriasis with Arthritis and Hearing Impairment in US Adults: Data from the National Health and Nutrition Examination Survey

Sudden-Onset Sensorineural Hearing Loss and Tinnitus in a Patient With Rheumatoid Arthritis: A Case Report and Literature Review

Idiopathic Inflammatory Arthritis in the Auditory Canal in a Patient With Hearing Impairment: A Case Report and Literature Review

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