An Update on Hidradenitis Suppurativa (Part I): Epidemiology, Clinical Aspects, and Definition of Disease Severity

Martorell, A.; García‐Martínez, Francisco Javier; Jiménez‐Gallo, David; Pascual, José C.; Pereyra‐Rodriguez, José Juan; Salgado, L.; Vilarrasa, Eva

doi:10.1016/j.adengl.2015.09.008

Cited by 38 publications

(39 citation statements)

References 75 publications

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“…], several schemes for hidradenitis suppurativa [Martorell et al. ], the disease severity scoring system (DS3) for type 1 Gaucher disease [Weinreb et al. ], the sepsis‐related organ failure assessment (SOFA) score [Vincent et al.…”

Section: Components Of Pathogenicitymentioning

confidence: 99%

“…Disease severity schemes and scoring systems have been developed for many conditions. These include the Follicular Lymphoma International Prognostic Index (IPI) [Solal-Celigny et al 2004], the Japanese severity score for acute pancreatitis [Hamada et al 2013], several schemes for hidradenitis suppurativa [Martorell et al 2015], the disease severity scoring system (DS3) for type 1 Gaucher disease [Weinreb et al 2010], the sepsis-related organ failure assessment (SOFA) score [Vincent et al 1996], and many others. Staging and grading systems are available for cancers (2010), chronic graft-versus-host disease [Filipovich et al 2005], idiopathic pulmonary disease [Homma et al 2015], chronic kidney disease [Levey et al 2005] and other diseases.…”

Section: Components Of Pathogenicitymentioning

confidence: 99%

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How to Define Pathogenicity, Health, and Disease?

Vihinen

2016

Human Mutation

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Scientific and clinical communities produce ever increasing amounts of data and details about health and disease. Our ability to understand and utilize this information is limited because of imprecise language and lack of well-defined concepts. This problem involves also the principal concepts of health, disease, and pathogenicity. Here, a systematic model is presented for pathogenicity, as well as for health and disease. It has three components: extent, modulation, and severity, which jointly define the continuum of pathogenicity. The model is population based, and once implemented, it can be used for numerous purposes such as diagnosis, patient stratification, prognosis, finding phenotype-genotype correlations, or explaining adverse drug reactions. The new model has several benefits including health economy by allowing evidence-based personalized/precision medicine.

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Section: Components Of Pathogenicitymentioning

confidence: 99%

Section: Components Of Pathogenicitymentioning

confidence: 99%

How to Define Pathogenicity, Health, and Disease?

Vihinen

2016

Human Mutation

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“…Furthermore, sonography has been proved useful for supporting the diagnosis of both pilonidal cysts and hidradenitis suppurativa and allows sonographic staging of hidradenitis suppurativa . The sonographic criteria for diagnosing hidradenitis suppurativa include abnormalities in the thickness and echogenicity of the dermis, the presence of dermal pseudocysts, as well as dermal and/or hypodermal fluid collections and fistulous tracts connected to the base of widened hair follicles, which commonly contain fragments of hair tracts.…”

mentioning

confidence: 99%

Sonographic Comparison of Morphologic Characteristics Between Pilonidal Cysts and Hidradenitis Suppurativa

Wortsman

Castro²,

Morales³

et al. 2017

J of Ultrasound Medicine

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Key lesions of pilonidal cysts and hidradenitis suppurativa have similar sonographic morphologic characteristics, which suggests that a pilonidal cyst may be a variant or localized form of hidradenitis suppurativa. The retained fragments of hair tracts frequently detected in both entities may be caused by ectopic production of hair and not by embedding. Common therapeutic strategies and research can be designed for both entities.

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“…US is also useful in treatment monitoring and follow‐up with the first sign of treatment response being represented by the decrease of inflammatory activity at colour Doppler. Other US signs of disease improvement include reduction/disappearance of fluid collections and fistulous tracts, and the likely presence of residual scarring appearing as epidermal and dermal parallel hyperechoic areas . A study on 40 HS patients evaluating the treatment response in different subtypes of fistulae, highlighted the importance of US in therapeutic planning: dermal and dermoepidermal fistulae showed a complete resolution after 6 months of different medical therapies in up to 95% and 65% of cases, respectively, whereas complex and subcutaneous fistulae showed no significant response after a medical intervention …”

Section: Ultrasound In Hidradenitis Suppurativamentioning

confidence: 99%

Ultrasonography in the pathway to an optimal standard of care of hidradenitis suppurativa: the Italian Ultrasound Working Group experience

Lacarrubba

Dini

Napolitano

et al. 2019

Acad Dermatol Venereol

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Background Ultrasound (US) is a real‐time non‐invasive technique that has been demonstrated to support an early diagnosis and a more precise assessment of hidradenitis suppurativa (HS). Objectives To compare the clinical and US evaluation of a series of HS patients. Methods 434 HS patients (259 F, 175 M; mean age 33.82 ±13.31 years) observed across 19 Italian dermatology centres [members of the Italian Ultrasound Working Group (IUWG)] were enrolled in a retrospective study. Clinical staging was obtained by the Hidradenitis Suppurativa Physician's Global Assessment score (HS‐PGA), while the ultrasonographic staging was determined by the US HS‐PGA, based on the same scores as clinical HS‐PGA but performed with the aid of US. Results At the end of the study, the mean clinical and US HS‐PGA scores were 2.70 and 2.92, respectively. Direct comparison of clinical and ultrasonographic assessment revealed that a higher proportion of patients was classified as having moderate and very severe disease by US. In particular, 117 patients (26.96%) had a worse classification by US HS‐PGA compared to clinical assessment. Conclusion Our findings confirm that the use of clinical grading only to assess HS severity may underestimate the real disease severity. US examination can be considered an essential non‐invasive imaging tool available to dermatologists for a more accurate diagnosis, staging, treatment planning and monitoring of HS and should be included in the pathway to an optimal standard of care of HS.

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An Update on Hidradenitis Suppurativa (Part I): Epidemiology, Clinical Aspects, and Definition of Disease Severity

Cited by 38 publications

References 75 publications

How to Define Pathogenicity, Health, and Disease?

How to Define Pathogenicity, Health, and Disease?

Sonographic Comparison of Morphologic Characteristics Between Pilonidal Cysts and Hidradenitis Suppurativa

Ultrasonography in the pathway to an optimal standard of care of hidradenitis suppurativa: the Italian Ultrasound Working Group experience

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