An update on imaging of Paget’s sarcoma

Clinical and Pathological Features of Osteosarcomas of the Jaws. A Retrospective Study

“…Regarding fibroblastic differentiation, there is a greater consensus regarding its lower incidence in OSJ [21,23]. OS of the epithelioid type is a rare variant with only 6 cases published in the jaw region [7,[38][39][40][41][42]. This variant, which was initially described by Scranton et al [43] in 1975, is more prevalent in long bones and in men (2:1), and can present itself between the 1st and 7th decade of life, with a predilection for the mandibular bone.…”

Paget's Disease or Densifying Metastasis: How to Sort It Out

“…Interestingly, metastases tend to occur in an eccentric location when present in long bones, in contrast to the central origin of osteosarcomas. 18 Primary lymphoma superimposed on Paget's disease can also present as a focal permeative lesion with or without a soft tissue mass ( Fig. 7 ).…”

“…7 ). 18 However, metastases, myeloma, and lymphoma may be indistinguishable from Paget's sarcoma when arising within bone affected by Paget's disease. Although not malignant, giant cell tumor can also occasionally involve pagetic bone.…”

“…Given the advanced age of most Paget patients, association with other malignancies such as metastases, myeloma, and primary lymphoma can be expected. 18 Because metastatic disease is usually multifocal, lesions within pagetic bone are unlikely to pose much of a diagnostic problem. 18 Onset of osteolysis with cortical destruction and an associated soft tissue mass are highly suggestive.…”

“…18 Because metastatic disease is usually multifocal, lesions within pagetic bone are unlikely to pose much of a diagnostic problem. 18 Onset of osteolysis with cortical destruction and an associated soft tissue mass are highly suggestive. Interestingly, metastases tend to occur in an eccentric location when present in long bones, in contrast to the central origin of osteosarcomas.…”