An Update on Kaposi’s Sarcoma: Epidemiology, Pathogenesis and Treatment

Curtiss, Paul; Strazzulla, Lauren C.; Friedman‐Kien, Alvin E.

doi:10.1007/s13555-016-0152-3

Cited by 63 publications

(63 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lesions may stay the same for months or become disseminated [1]. Su et al [6] reported that the duration of the lesions ranged between 3 months and 25 years.…”

Section: Discussionmentioning

confidence: 99%

“…The aim of the treatment is to reduce symptoms, relieve lymphedema, reduce the number of lesions, and prevent progression. Local and systemic tumor-directed treatments can be used [1,4]. Given that KS does not affect life expectancy, effective local treatments should be considered as first line treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Kaposi's sarcoma (KS) is a multifocal angioproliferative tumor involving primarily the skin [1]. It was first introduced in 1872 by Moritz Kaposi as idiopathic multiple pigmented sarcoma of the skin [2].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Retrospective Analysis of 91 Kaposi’s Sarcoma Cases: A Single-Center Experience and Review of the Literature

Yazıcı¹,

Zorlu²,

Başkan³

et al. 2018

Dermatology

View full text Add to dashboard Cite

Background: Kaposi’s sarcoma (KS) is a multifocal angioproliferative tumor involving primarily the skin. Objective: The aim of this study was to describe the clinical, demographic, histopathological characteristics, treatment modalities, and outcome of 91 KS patients, and compare them with other contemporary research. Methods: Medical records of 91 KS patients followed between January 2005 and September 2017 were evaluated retrospectively. Results: Most of our patients were male (male-to-female ratio was 4.05). The median age at diagnosis was 69 years (range, 6–93 years). The duration of the lesions varied between 3 and 25 years. The lower extremities were the most commonly involved area (51.6%). Of the 91 patients, classic type KS was seen in 75 patients. Radiotherapy was used successfully in approximately half of our patients. Recurrence was observed in approximately one third of the patients. All KS patients in this study except 1 were classic KS. Conclusion: The clinical and demographic characteristics of our patients were compatible with the previous literature suggesting that KS is a tumor that tends to be limited to the skin. Close follow-up of patients is important to monitor for recurrence. This is the largest report from Turkey to date.

show abstract

“…Lesions may stay the same for months or become disseminated [1]. Su et al [6] reported that the duration of the lesions ranged between 3 months and 25 years.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Retrospective Analysis of 91 Kaposi’s Sarcoma Cases: A Single-Center Experience and Review of the Literature

Yazıcı¹,

Zorlu²,

Başkan³

et al. 2018

Dermatology

View full text Add to dashboard Cite

show abstract

“…İyatrojenik Kaposi sarkomu özellikle organ transplantasyonu yapılan hastalarda immünsupresif tedavi alımına bağlı ortaya çıkmaktadır. Bununla birlikte başka nedenlerden dolayı uzun dönem kortikosteroid kullanımı, rituximab, infliximab ve abatacept içeren biyolojik ajanlarla tedavi alan hastalarda da sıklığı artmaktadır (8). Literatürde, 12 hasta ile yapılan bir çalışmada immünsupresif tedavi almaya devam eden hastaların %91,6'sında Kaposi sarkomuna bağlı cilt lezyonlarının arttığı, buna karşın immünsupresif tedavinin azaltılması durumunda ise %11,7 hastada greft reddi saptanmıştır.…”

Section: Discussionunclassified

Böbrek Nakilli Hastada Hiperbilirubinemi ile Seyreden İğsi Hücreli Neoplazm: Nadir Bir Olgu Sunumu

Çırak¹,

Koçyiğit²,

Denız³

et al. 2018

Turk Neph Dial Transpl

View full text Add to dashboard Cite

ÖZOrgan transplantasyonu yapılan hastalarda nakil sonrası süreçte neoplazm riski artmaktadır. Bu duruma yol açan en önemli sebepler immünsupresif tedaviler ve onkojenik virüslerdir. Onkojenik virüsler içerisinde ise Epstein-Barr virüs (EBV) ve Human Herpes virüs 8 (HHV-8) en sık saptanan virüslerdir. Burada, 70 yaşında, böbrek nakli sonrası dördüncü yılında olup immünsupresif tedavi alan, ciltte sarılık ve genel durum bozukluğu ile başvuran, karaciğerde iğsi hücreli neoplazm saptanan bir olgu sunulmuştur. ANAHTAR SÖZCÜKLER: Böbrek nakli, İmmünsupresyon, Neoplazi ABSTRACTThe risk of neoplasm increases after transplantation in patients with organ transplantation. Immunosuppressive treatments or oncogenic viruses are major risk factors. Epstein-Barr virus (EBV) and Human are the most frequently shown types among oncogenic viruses. Herein, we present a case of spindle cell neoplasm in a 70-year-old renal transplant recipient who underwent immunosuppressive treatment for 4 years, and presented with jaundice and fatique.

show abstract

“…Indeed, the Tat protein -with the help of its sequences of arginine and lysin -has properties which support not only the angiogenesis (by β-fibroblast growth factor and vascular endothelial growth factor A) but also the migration, proliferation, and expression of affected cells [7,8]. The elementary dermatological lesion in KS is an erythematous, angiomatous, and purplish macule which infiltrates gradually to become a papule, then a nodule, finally leading to the formation of broad plates resulting from the junction of budding cutaneous lesions; in addition, lymphedemas are seen more often [6,9].…”

mentioning

confidence: 99%

Epidemiological and Clinical Patterns of Kaposi Sarcoma: A 16-Year Retrospective Cross-Sectional Study from Yaoundé, Cameroon

Tounouga

Kouotou²,

Nansseu³

et al. 2018

Dermatology

View full text Add to dashboard Cite

Background: The burden of Kaposi sarcoma (KS) is increasing fast among HIV-infected populations, but the disease remains desperately underexplored in Cameroon, where the burden of HIV is high. Methods: This is a retrospective cross-sectional study carried out over a period of 16 years (January 2001 to December 2016) at the HIV day care unit of the Central Hospital of Yaoundé, Cameroon. The diagnosis was based on clinical aspects and histological confirmation, and we used a preconstructed questionnaire for data collection through patients’ electronic and physical files. Results: Among 14,220 files reviewed, 316 cases of KS were identified, yielding a cumulative incidence of 2.2%. In the end, 266 patients (55% male) were included in this study. The patients’ age ranged from 17 to 72 years, with a mean of 37.8 ± 9.5 years. KS was the presenting manifestation of HIV in 89.8% of the cases. Cutaneous lesions occurred more often (81.6%), mainly located on the lower limbs (47.7%); mucous lesions were found in 15.8% of the patients, while 8 patients (3.0%) had associated visceral lesions. The lesions predominantly were lymphedemas (28.6%) and papulonodules (21.1%). At the diagnosis of KS, the median CD4 count was 175 cells/mm³ (interquartile range 80.5–288.5), and 150 patients (56.6%) had CD4 counts < 200 cells/mm³. Conclusions: KS is frequent among our HIV-infected patients; it seems to occur most often at a younger adult age and represents one of the presenting manifestations of HIV/AIDS in our context. It seems to equally affect men and women, occurring more often when CD4 counts are < 200 cells/mm³.

show abstract

An Update on Kaposi’s Sarcoma: Epidemiology, Pathogenesis and Treatment

Cited by 63 publications

References 32 publications

Retrospective Analysis of 91 Kaposi’s Sarcoma Cases: A Single-Center Experience and Review of the Literature

Retrospective Analysis of 91 Kaposi’s Sarcoma Cases: A Single-Center Experience and Review of the Literature

Böbrek Nakilli Hastada Hiperbilirubinemi ile Seyreden İğsi Hücreli Neoplazm: Nadir Bir Olgu Sunumu

Epidemiological and Clinical Patterns of Kaposi Sarcoma: A 16-Year Retrospective Cross-Sectional Study from Yaoundé, Cameroon

Contact Info

Product

Resources

About