An update on optical coherence tomography angiography in diabetic retinopathy

Khadamy, Joobin; Aghdam, Kaveh Abri; Falavarjani, Khalil Ghasemi

doi:10.4103/jovr.jovr_57_18

Cited by 98 publications

(38 citation statements)

References 115 publications

(360 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DR produces a decrease in capillary vascular mesh in superficial and deep plexuses, which is greater as the severity of DR increases,33–35 and is earlier and more pronounced in the deep plexus than in the superficial one 5,8,27. Similarly, in our report, the mean VD in both plexuses is reduced in patients with DR versus controls.…”

Section: Discussionsupporting

confidence: 81%

See 1 more Smart Citation

Structure–Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy

Alonso-Plasencia

Abreu-González

Gomez-Culebras

2019

OPTH

View full text Add to dashboard Cite

PurposeTo evaluate macular vasculature in diabetic retinopathy (DR) with optical coherence tomography angiography (OCTA) and to correlate vessel density (VD) with retinal sensitivity (RS) as a way to assess structural and functional findings in DR.DesignProspective observational cross-sectional study.MethodsDiabetic patients with DR but no clinically significant diabetic macular edema (DME) and healthy subjects were included in this study. All of them underwent comprehensive ophthalmic examination, best corrected visual acuity (BCVA), OCTA with RS-3000 Advance AngioScan (Nidek, Gamagori, Japan) and microperimetry with MP-3 (Nidek, Gamagori, Japan). Retinal vascular density measured by OCT angiography in 9 areas was correlated with RS in the same 9 areas by Spearman correlation.ResultsIn this study, 50 subjects were enrolled: 25 eyes of diabetic patients with DR and 25 eyes of non-diabetic subjects. Diabetic patients mean age was 51.88±13.62 years; non-diabetic subjects were 43.48±13.42 years. The BCVA was 20/25 in the diabetic group and 20/20 in the non-diabetic group. Mean RS was decreased in the DR group (27.68±2.71 dB) compared to the non-diabetic group (31.68±1.46 dB) (p<0.05) and in the 9 studied areas (p<0.05). Mean VD was decreased in the DR group compared to non-diabetics (p<0.05) and in 7 of the 9 areas (except temporal superior and inferior squares) (p<0.05). Correlations by areas between VD and RS were assessed, we found moderate correlation in the area temporal to the fovea (r=0.501, p=0.01) in the DR group but not in the non-diabetic subjects. There were no other statistical significant correlations with this pattern.ConclusionDR without DME results in a retinal VD decreased that might be the cause of a reduction of RS in one of the studied areas. Microangiopathic changes are correlated with microperimetry sensitivity drop in the temporal to the fovea grid but not in the other studied grids.

show abstract

Section: Discussionsupporting

confidence: 81%

“…Likewise, there is a rising number of publications about OCTA and DR,27 however, nowadays the application of this new technology in clinical practice has still not been settled down. Through the application of image processing and analysis software, OCTA allows us to compare data of the main changes in the macula of diabetics.…”

Section: Discussionmentioning

confidence: 99%

Structure–Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy

Alonso-Plasencia

Abreu-González

Gomez-Culebras

2019

OPTH

View full text Add to dashboard Cite

show abstract

“…OCTA is a new imaging technique which can assess the retinal and choroidal microvasculature. [2][3][4][5][6][7][8][9][10][11][12] It allows demonstration of the blood flow in both superficial and deep retinal capillary layers, so it can delineate the microvascular changes in DR, such as irregular FAZ, areas of capillary dropout and neovascularization, which have serious effects on visual acuity. 15 The aim of the current study was to demonstrate the impact of these microvascular changes on the vision of patients with DR by analyzing the correlation between visual acuity and retinal vessel density, as well as the area of FAZ, using OCTA.…”

Section: Discussionmentioning

confidence: 99%

“…2,[6][7][8] The retinal microvascular changes in DR may lead to visually fatal complications, including macular ischemia, neovascularization and macular edema. 9 Recent research has highlighted the potential role of this new imaging modality in assessing the retinal microvascular abnormalities in various retinal diseases, including DR. [7][8][9][10] The quantitative OCTA parameters, such as foveal avascular zone (FAZ) area, vessel density, and perfusion density in the superficial and deep capillary plexus, may have a useful role in the early detection of subclinical disease and may also provide valuable biomarkers in monitoring the progression of DR and preventing its severe complications. [11][12][13] The aim of the current study was to assess the correlation between best corrected visual acuity (BCVA) and different OCTA parameters in patients with DR.…”

Section: Introductionmentioning

confidence: 99%

Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy

Abdelshafy

2020

OPTH

View full text Add to dashboard Cite

The aim of this study was to assess the correlation between different optical coherence tomography angiography (OCTA) parameters and the best corrected visual acuity (BCVA) in patients with diabetic retinopathy (DR). Patients and Methods: Sixty eyes of 60 participants were included in this prospective study: 40 diabetic patients [20 with non-proliferative diabetic retinopathy (NPDR group), 20 with proliferative diabetic retinopathy (PDR group)] and 20 age-and gender-matched normal healthy subjects (control group). After full ophthalmological examination and fundus fluorescein angiography, OCTA was performed for all participants. Quantitative OCTA parameters, such as the foveal avascular zone (FAZ) area, the superficial capillary plexus vessel density (%) (SCP-VD) and the deep capillary plexus vessel density (%) (DCP-VD) in, whole and parafoveal areas were measured. Correlations between BCVA and OCTA parameters were analyzed. Results: There were no statistically significant differences between groups regarding age, gender, refraction, macular thickness or intraocular pressure. The median (IQR) FAZ area was 0.42 (0.39-0.46) mm 2 in the NPDR group, 0.54 (0.45-0.65) mm 2 in the PDR group and 0.24 (0.21-0.26) mm 2 in the control group (P<0.001). The FAZ area increased with increasing severity of DR. SCP-VD and DCP-VD showed significant differences between groups (P<0.001). Vessel density (VD) was decreased in both DCP and SCP as DR progressed. There was a significant positive correlation between BCVA (LogMAR) and FAZ area. There were significant negative correlations between BCVA (LogMAR) and VD in both SCP and DCP. Stepwise multiple linear regression analysis demonstrated that SCP-VD in the whole area and DCP-VD in the parafoveal area were the best predictive factors for BCVA in the NPDR and PDR groups. Conclusion: With progression of DR, the VD decreased and the FAZ area increased, and both parameters were correlated with poor visual acuity. OCTA is a non-invasive tool which can be used to detect diabetic macular ischemia and help in the prediction of visual prognosis.

show abstract

“…The prominent difference in vessel alteration and the FAZ indicated that the retinal vasculature may change in some patients with DME after DEX implantation. Although diabetic retinopathy would uneventfully enlarge the FAZ, which progressed with the disease severity,18 no severe complications, such as vitreous hemorrhage or tractional retinal detachment, were found during the two-month period. In addition, the blood sugar level was 212 mg/dL and 171 mg/dL before and two months after the DEX implantation, and the glycosylated hemoglobin was 7.3 percent and 7.0 percent before and two months after the DEX implantation, implied that the progression of diabetes mellitus was not likely.…”

Section: Discussionmentioning

confidence: 91%

Retinal angiographic alteration in diabetic macular edema after dexamethasone implantation: a case report

Lee¹,

Ching²,

Sun³

et al. 2019

IMCRJ

View full text Add to dashboard Cite

Here we reported a rare case of the implantation of a dexamethasone intravitreal implant (DEX) in which decreased retinal vessel density (VD) was found by optical coherence tomography angiography (OCTA). A 74-year-old male with diabetes mellitus presented with bilateral macular edema. The best-corrected visual acuity (BCVA) was 0.6 in the right eye. Diabetic macular edema (DME) was diagnosed. A DEX for the right eye was planned, and the preoperative evaluation showed a superficial VD of 48.74 percent, a deep VD of 53.12 percent, and a foveal avascular zone (FAZ) 0.165 mm 2 in size by OCTA. The BCVA in the right eye recovered to 0.8, and a notably lower superficial VD of 45.97 percent and a deep VD of 45.40 percent were observed with an enlarged FAZ of 0.294 mm 2 one month postoperatively. Moreover, BCVA in the right eye was maintained at 0.8, while further reductions in both superficial (40.07 percent) and deep (40.91 percent) VD were noted with a FAZ measured at 0.305 mm 2 two months postoperatively. In conclusion, retinal superficial and deep VD decreased, while the FAZ increased, after the implantation of the DEX in a patient with DME.

show abstract

An update on optical coherence tomography angiography in diabetic retinopathy

Cited by 98 publications

References 115 publications

<p>Structure–Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy</p>

<p>Structure–Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy</p>

<p>Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy</p>

<p>Retinal angiographic alteration in diabetic macular edema after dexamethasone implantation: a case report</p>

Contact Info

Product

Resources

About