“… 12 In addition, flucloxacillin and ticarcilin-clavulanato were used in one case each, although the regimen was not specified. 21 , 22 In the lincosamide class, clindamycin 300 mg was the drug of choice, with a 4× daily regimen for 14 days in one case, 6 although in the other two articles the regimen was not specified; 14 , 22 in addition to lincomycin 500 mg for 10 days, used in one case. 23 …”
Section: Resultsmentioning
confidence: 99%
“… 17 Our results were consistent with the literature, with the mandible being the most affected site (n = 22). 2 , 5 , 6 , 11 , 12 , 13 , 14 , 15 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 27 , 28 , 29 , 30 …”
Section: Discussionmentioning
confidence: 99%
“…Oral manifestations include an obtuse mandibular angle, malocclusion, an ogival palate, and dental anomalies. 1 , 6 The abnormal bone metabolism increases the susceptibility of patients to develop osteomyelitis. In gnathic bones, local factors related to the development of osteomyelitis include the bone characteristics of the maxilla and mandible, continuous traumas, alveolar surgical procedures, and conditions that affect the teeth such as periapical and periodontal disease.…”
“… 12 In addition, flucloxacillin and ticarcilin-clavulanato were used in one case each, although the regimen was not specified. 21 , 22 In the lincosamide class, clindamycin 300 mg was the drug of choice, with a 4× daily regimen for 14 days in one case, 6 although in the other two articles the regimen was not specified; 14 , 22 in addition to lincomycin 500 mg for 10 days, used in one case. 23 …”
Section: Resultsmentioning
confidence: 99%
“… 17 Our results were consistent with the literature, with the mandible being the most affected site (n = 22). 2 , 5 , 6 , 11 , 12 , 13 , 14 , 15 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 27 , 28 , 29 , 30 …”
Section: Discussionmentioning
confidence: 99%
“…Oral manifestations include an obtuse mandibular angle, malocclusion, an ogival palate, and dental anomalies. 1 , 6 The abnormal bone metabolism increases the susceptibility of patients to develop osteomyelitis. In gnathic bones, local factors related to the development of osteomyelitis include the bone characteristics of the maxilla and mandible, continuous traumas, alveolar surgical procedures, and conditions that affect the teeth such as periapical and periodontal disease.…”
“…Most publications refer to dentistry and maxillofacial surgery but not to traumatology and/or orthopedics. Another search based on Mesh terms "Osteomyelitis" and "Metabolic disorders" (latest access time: December 08, 2019, 0:03 UTC +3) has provided 596 results, but most papers refer to other topics and problems: "combinations" of chronic osteomyelitis and diabetes mellitus [1,2], chronic osteomyelitis and bisphosphonate-induced necrosis of the jaw [3,4]; less papers refer to the problem of treating chronic osteomyelitis in patients with genetic, systemic, neuropathic, and oncological diseases [5][6][7][8]. In several papers, the accent is put on the clinical aspects of bone infection with particular pathogens only [9][10][11].…”
In this study, we discuss the peculiarities of metabolic disorders that follow the development of chronic osteomyelitis. For the purposes of this study, we analyzed the available data as well as results of our own clinical and scientific research. Chronic osteomyelitis leads not only to the destruction of bone tissue by pathogen but also to the shift of equilibrium between osteogenesis and bone resorption in the locus of bone infections. Such shift leads to additional damage not only to the bone cells (primarily osteoblasts) but also to the bone matrix. The final complications include difficulties with bone consolidation and prolongation of therapy, even when the patient is treated using an external fixation method like Ilizarov or similar techniques. Etiopathogenetic therapy, aimed at correction of metabolic disorders, allows to shorten the bone consolidation time (and respectively, the treatment time), preventing different pathogenetic processes that exacerbate and enhance each other’s effects. This study emphasizes the importance of etiopathogenetic therapy of metabolic disorders in patients with chronic osteomyelitis. Etiopathogenetic therapy should be combined with other necessary methods of the patient’s treatment, such as surgical debridement of the infection locus and antibiotic therapy.
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