An Update on Stiripentol Mechanisms of Action: A Narrative Review
Alexandre Bacq,
Antoine Depaulis,
Vincent Castagné
et al.
Abstract:Stiripentol (Diacomit
®
) (STP) is an orally active antiseizure medication (ASM) indicated as adjunctive therapy, for the treatment of seizures associated with Dravet syndrome (DS), a severe form of childhood epilepsy, in conjunction with clobazam and, in some regions valproic acid. Since the discovery of STP, several mechanisms of action (MoA) have been described that may explain its specific effect on seizures associated with DS. STP is mainly considered as a potentiator of gamma-amino… Show more
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