An Update on Terminology and Reporting

Batts, Kenneth P.; Ludwig, Jürgen

doi:10.1097/00000478-199512000-00007

Cited by 1,013 publications

(689 citation statements)

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“…Histopathological interpretation was provided by a single hepatopathologist who was blinded to clinical information (inlcuding MR Elastography results) at initial evaluation in all cases. Fibrosis staging was assessed using classification systems developed for the specific liver disease etiologies under study including the METAVIR system for chronic viral and autoimmune hepatitis (35), the Brunt classification for nonalcoholic fatty liver disease (36), and the Batts-Ludwig system for cholestatic liver disease (37).…”

Section: Liver Histopathologymentioning

confidence: 99%

Assessment of Hepatic Fibrosis With Magnetic Resonance Elastography

Yin

Talwalkar

Glaser

et al. 2007

Clinical Gastroenterology and Hepatology

855

809

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Background & Aims-Accurate detection of hepatic fibrosis is crucial for assessing prognosis and candidacy for treatment in patients with chronic liver disease. Magnetic Resonance (MR) Elastography, a technique for quantitatively assessing the mechanical properties of soft tissues, has previously been shown to have potential for non-invasively detecting liver fibrosis. The goal of this work was to obtain preliminary estimates of the sensitivity and specificity of the technique in diagnosing liver fibrosis, and to assess its potential for identifying patients who can potentially avoid biopsy.

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Section: Liver Histopathologymentioning

confidence: 99%

Assessment of Hepatic Fibrosis With Magnetic Resonance Elastography

Yin

Talwalkar

Glaser

et al. 2007

Clinical Gastroenterology and Hepatology

855

809

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“…Global inflammation grade (0-4) and fibrosis stage (0-4) was assessed according to the standardized semiquantitative histological scoring system developed by Batts and Ludwig [29]. Portal inflammation was reported separately (0-4), as described by Knodell et al [30].…”

Section: Histopathologymentioning

confidence: 99%

High prevalence of autoantibodies to C-reactive protein in patients with chronic hepatitis C infection: association with liver fibrosis and portal inflammation

et al. 2012

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The presence of autoantibodies against C-reactive protein (anti-CRP) has been reported in association with autoimmunity and histopathology in chronic hepatitis C virus (HCV) infection. Resistin could play a role in the pathogenesis of hepatitis, although results on HCV infection are ambiguous. Here we retrospectively analyzed anti-CRP and resistin levels in the sera of 38 untreated and well-characterized HCV patients at the time of their first liver biopsy. HCV activity and general health were assessed by a physician at least yearly until follow-up ended. Anti-CRP and resistin were also measured in patients with autoimmune hepatitis (AIH) and nonalcoholic fatty liver disease (NAFLD). Anti-CRP antibodies were registered in all HCV patients, whereas only a few AIH (11%) and NAFLD (12%) sera were positive. Anti-CRP levels were related to histopathological severity and were highest in patients with cirrhosis at baseline. Resistin levels were similar in HCV, AIH, and NAFLD patients, but high levels of resistin were associated with early mortality in HCV patients. Neither anti-CRP nor resistin predicted a response to interferon-based therapy or cirrhosis development or was associated with liver-related mortality. We conclude that anti-CRP antibodies are frequently observed in chronic HCV infection and could be a useful marker of advanced fibrosis and portal inflammation.Funding Agencies|Swedish Society for Medical Research||Professor Nanna Svartz Foundation||King Gustaf V 80-Year Foundation||Sweden-America Foundation||County Council of Ostergotland||Clas Groschinsky||byggmastare Olle Engkvist||apotekare Hedberg|

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“…Inflammation was graded as follows: 0, no inflammation; 1, mild portal inflammation, no interface hepatitis; 2, mild/moderate portal inflammation, interface hepatitis in some but not all portal tracts; 3, moderate portal inflammation, interface hepatitis in the majority of por-tal tracts; and 4, severe portal inflammation with bridging necrosis. 10 …”

Section: Histologymentioning

confidence: 99%

Graft histology characteristics in long-term survivors of pediatric liver transplantation

et al. 2008

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The factors that influence the long‐term histological outcome of transplanted liver allografts in children are not yet fully understood, and the role of surveillance biopsies in patients with normal graft function remains controversial. The aims of this study were to describe the long‐term graft histology of pediatric liver transplant recipients surviving at least 3 years and to analyze factors correlating with long‐term histological outcome. Histological slides of 63 long‐term liver transplant recipients were assessed for inflammation and fibrosis. The histological findings were correlated with clinical, biochemical, serological, and radiological findings. A significant proportion of biopsies from these patients showed some type of histological abnormalities, with fibrosis being observed in 61 (97%) patients. Duration of transplantation of >6 years and ≥grade 2 inflammation were significantly associated with advanced fibrosis. We could not identify any correlation between ≥stage 3 fibrosis and donor age, cold and warm ischemia time, history of de novo autoimmune hepatitis, hepatic artery thrombosis, chronic rejection, or alanine aminotransferase, aspartate aminotransferase, and gamma‐glutamyl transferase values. In conclusion, liver fibrosis appears to be a common finding in long‐term pediatric liver transplant survivors. The cause of this fibrosis is uncertain, and normal alanine aminotransferase, aspartate aminotransferase, and gamma‐glutamyl transferase levels do not exclude the presence of significant fibrosis. Liver Transpl 14:1582–1587, 2008. © 2008 AASLD.

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An Update on Terminology and Reporting

Cited by 1,013 publications

References 0 publications

Assessment of Hepatic Fibrosis With Magnetic Resonance Elastography

Assessment of Hepatic Fibrosis With Magnetic Resonance Elastography

High prevalence of autoantibodies to C-reactive protein in patients with chronic hepatitis C infection: association with liver fibrosis and portal inflammation

Graft histology characteristics in long-term survivors of pediatric liver transplantation

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