An update on the current epidemiological status of metastatic neoplasms to the thyroid

Nguyen, Marie; He, George; Lam, Alfred King‐Yin

doi:10.1016/j.canep.2022.102192

Cited by 5 publications

(3 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among these ten cases, a single one arose synchronously with HCC, while the remaining nine manifested heterochronously, affording an average latency of 20.1 months. A significantly higher male to female ratio (7:3) was discernible, reflecting the pervasive higher incidence and mortality rate of HCC in males ( 15 ).Patients showed salient clinical manifestations similar to primary thyroid neoplasms encompassing goiter, neck swelling, dysphagia, dysphonia, hoarseness, and coughing ( 16 ). These typical clinical symptoms could serve as pointers for detecting metastatic carcinoma in the thyroid gland, although such symptoms are infrequent thus often leading to the delayed diagnosis of thyroid metastases.…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemical evaluations play a critical role in demarcating secondary thyroid malignancies from their primary counterparts. Namely, the detection of immunopositive staining for thyroglobulin and the thyroid transcription factor-1 (TTF-1) can indicate primary thyroid neoplasms ( 16 ). In contrast, secondary thyroid neoplasms typically do not display these markers; but instead, express unique indicators tied to their tissue of origin, such as alpha-fetoprotein (AFP) and hepatocytes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Case report: Thyroid metastasis from hepatocellular carcinoma: a rare case with diffuse solid occupancy and unusual imaging findings

Feng,

Xue,

Sang

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

BackgroundThyroid metastasis represents a rare occurrence, with commonly observed primary tumors originating from renal cell carcinoma, malignant neoplasms of the gastrointestinal tract, lungs, and breast. However, the metastasis of hepatocellular carcinoma to the thyroid gland remains infrequent. Previous investigations have consistently demonstrated an unfavorable prognosis for patients with malignancies that have metastasized to the thyroid. In this context, we present a noteworthy case of thyroid metastasis from hepatocellular carcinoma (HCC), characterized by a distinct ultrasonographic manifestation of diffuse thyroid lesion, deviating from the previously documented imaging presentations of thyroid metastases in HCC.Case presentationA 62-year-old Chinese female patient was diagnosed with hepatocellular liver cancer in 2019, following which she underwent a radical hepatic resection. Pathological examination revealed HCC located in the right lobe (stage T3bN0M0 IIIB). No additional interventions were administered subsequent to the surgery. After a span of 15 months, the patient presented with dyspnea. Ultrasonographic findings showed diffuse solid infiltration within the thyroid gland, along with tumor thrombi in both internal jugular veins. Computed tomography (CT) scans demonstrated malignant thyroid lesions infiltrating the retropharyngeal space, prevertebral space, and esophageal wall. The subsequent pathology report from the puncture biopsy confirmed the malignant nature of the tumor, and immunohistochemical analysis definitively established its hepatic origin.ConclusionsPatients with a history of HCC should be subjected to long-term monitoring and habitual thyroid ultrasonography. Newly detected thyroid nodules in such patients should be immediately regarded suspect for potential metastatic disease. Even when a nodule doesn’t exhibit malignant characteristics on ultrasound, FNAB should be administered promptly to elucidate the pathological condition. Larger, swiftly multiplying thyroid masses should warrant an immediate CNB. The identification of thyroid metastases, particularly when coupled with peripheral tissue invasion, typically signifies a bleak prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Case report: Thyroid metastasis from hepatocellular carcinoma: a rare case with diffuse solid occupancy and unusual imaging findings

Feng,

Xue,

Sang

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…Fewer than 10% of all thyroid nodules are malignant and most of these neoplasms arise from the thyroid itself 2 . The data are varied, but in clinical series, about 1.9% of all malignancies found in the thyroid are reported to arise from a primary cancer outside of the thyroid 3 . Solid tumors originating from the kidney, lung, breast, and gastrointestinal (GI) tract are the prevalent sources of metastases to the thyroid gland 4 – 9 ; additionally, cases of primary lymphoma have been documented 10 .…”

Section: Introductionmentioning

confidence: 99%

Use of PSMA PET/CT to detect prostate cancer metastatic to a preexisting thyroid nodule

Chalker,

Yilmaz,

Trone

et al. 2024

npj Precis. Onc.

View full text Add to dashboard Cite

Prostate cancer (PCa) seldom metastasizes to the thyroid gland, and only a limited number of cases are documented in the literature. The application of a relatively recent and highly sensitive imaging technique, prostate-specific membrane antigen (PSMA) positron emission tomography—computed tomography (PET/CT), has enhanced the identification of metastatic disease. Nevertheless, as PSMA is expressed in various tissue types, the clinical importance of a PSMA-avid thyroid lesion remains largely uncertain. A minor, yet noteworthy, percentage of these lesions are ultimately determined to be malignant. Here we describe the case of a 70-year-old man with a past medical history of Lynch syndrome who presented to an outpatient oncologic clinic for management of very high risk localized PCa. He developed metastatic recurrence and his disease progressed through several lines of therapy, including immunotherapy and targeted treatments. He was found to have a new, intense PSMA uptake in an existing, previously benign thyroid nodule. Sonographic evaluation revealed changing morphology despite grossly stable size. Repeat biopsy confirmed the unusual finding of PCa metastasis to a known thyroid nodule. The shift in PSMA avidity played a pivotal role in discerning this metastatic deposit. There is a potential risk that such lesions may be inadequately acknowledged. The impact of the patient’s Lynch syndrome on this presentation remains uncertain.

show abstract

Metastatic Disease to a Concurrent Thyroid Neoplasm: A Case Series and Review of the Literature

Garneau

Alyzadneh

Lal

et al. 2023

Head and Neck Pathol

View full text Add to dashboard Cite

An update on the current epidemiological status of metastatic neoplasms to the thyroid

Cited by 5 publications

References 43 publications

Case report: Thyroid metastasis from hepatocellular carcinoma: a rare case with diffuse solid occupancy and unusual imaging findings

Case report: Thyroid metastasis from hepatocellular carcinoma: a rare case with diffuse solid occupancy and unusual imaging findings

Use of PSMA PET/CT to detect prostate cancer metastatic to a preexisting thyroid nodule

Metastatic Disease to a Concurrent Thyroid Neoplasm: A Case Series and Review of the Literature

Contact Info

Product

Resources

About