An update on the evaluation and management of iron deficiency anemia in inflammatory bowel disease

Aksan, A; Farrag, Karima; Stein, Jürgen M.

doi:10.1080/17474124.2019.1553618

Cited by 7 publications

(7 citation statements)

References 12 publications

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“…It is important to emphasize that measurement of hemoglobin levels and serum iron alone is insufficient: hemoglobin measurements only allow diagnosis of the third and last stage of IDA (1,18) . Thus, it is possible that the prevalence of iron deficiency is underestimated, especially if measurement of serum ferritin is not part of the routine diagnosis.…”

Section: Resultsmentioning

confidence: 99%

“…Iron deficiency with or without anemia has been reported to affect 13%-90% of IBD patients, depending on some characteristics of the studied population (e.g., gender, age at diagnosis, disease activity, hospitalization and previous surgeries) (4,(8)(9)(10)(11)(12)(13)(14)(15) . In most cases, IBD-associated anemia is due to the combination of chronic iron deficiency anemia (IDA) and anemia of chronic disease (ACD) (1,(16)(17)(18) . Recently, Akhuemonkhan et al (17) showed that most patients with IBD (67%) are screened for anemia at least once during the median 2-year follow-up period.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anemia and Iron Deficiency in Inflammatory Bowel Disease Patients in a Referral Center in Brazil: Prevalence and Risk Factors

Parra

Feitosa

Ferreira

et al. 2020

Arq. Gastroenterol.

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BACKGROUND: Data regarding the prevalence of anemia in inflammatory bowel disease (IBD) patients are scarce in Brazil. Anemia and iron deficiency anemia have been known to cause significant functional impairment, lower quality of life, and higher morbidity and mortality and may be correlated with an impact on the cost of treatment. OBJECTIVE: The aim of this study was to estimate the prevalence and risk factors for anemia and iron deficiency anemia in patients with IBD in a tertiary IBD unit in Southeast Brazil. METHODS: We conducted an Institutional Review Board-approved retrospective analysis of an adult IBD cohort (IBD Unit, Ribeirão Preto Medical School, University of São Paulo, Brazil) consisting of 579 patients between January 2014 and July 2018. Clinicoepidemiological data, hemoglobin measurements and serum ferritin were extracted from electronic medical records. Anemia prevalence was calculated among ulcerative colitis (UC) and Crohn’s disease (CD) phenotypes. Risk factors for anemia were also calculated. RESULTS: A total of 529 (91%) patients had complete blood counts available in their medical records. Only 35.5% of IBD patients were fully screened for anemia. The prevalence of anemia in IBD patients was 24.6% (29.1% in CD and 19.1% in UC, P=0.008). The anemia was moderate to severe in 16.9% (19.8% in CD and 11.4% in UC, P=0.34). The prevalence of iron deficiency was 52.3% (53.6% in CD and 51.2% in UC, P=0.95). Anemia of chronic disease was present in 14.1% of IBD patients. A total of 53.8% of patients with anemia were in clinical remission. CD was associated with an increased prevalence of anemia (P=0.008; OR=1.76; CI 95% =1.16-2.66) compared to UC. The penetrant disease phenotype in CD was associated with a lower risk of anemia (P<0.0001; OR=0.25; CI 95% =0.14-0.43). Active disease compared to the disease in clinical remission was associated with an increased risk of anemia (P=0.0003; OR=2.61; CI 95% =1.56-4.36) in CD. The presence of anemia was less frequent in patients with CD who underwent surgical bowel resection compared to those who did not undergo surgery (P<0.0001; OR=0.24; CI 95% =0.14-0.40). No differences in anemia prevalence were observed regarding CD localization, age at diagnosis, UC extension or biological therapy (P>0.05). CONCLUSION: Despite the low levels of full screening, anemia and iron deficiency anemia were common manifestations of IBD. CD was associated with an increased risk of anemia, especially with active disease. In addition, patients with CD who underwent surgical bowel resection and penetrant disease phenotype in CD were associated with lower risk of anemia.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anemia and Iron Deficiency in Inflammatory Bowel Disease Patients in a Referral Center in Brazil: Prevalence and Risk Factors

Parra

Feitosa

Ferreira

et al. 2020

Arq. Gastroenterol.

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“…We would further note that, despite the above verbatim quote on the lack of statistical significance in efficacy differences between IV iron formulations, the authors have recently published an editorial citing the very same study and noting adjacent to the citation that: “this study shows for the first time significant differences in efficacy and safety of the different intravenous iron preparations in patients with IBD” [6]. Not only was no formal analysis of safety conducted in the NMA but this recent reporting of significance is a direct contradiction of the original study.…”

Section: Assumption That Iim and Fcm Are Equal In Efficacy And Safetymentioning

confidence: 99%

Response: An Economic Evaluation of Iron Isomaltoside 1000 Versus Ferric Carboxymaltose in Patients with Inflammatory Bowel Disease and Iron Deficiency Anemia in Denmark

Pollock¹,

Muduma

2019

Adv Ther

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“…Any people with CD get blood in the stool with inflamed tissues in the Intestines; persistent bleeding may lead to (anemia). In certain situations, CD may result as well in causing inflammations in the eyes, skin, or join ts 3,4 .…”

Section: Introductionmentioning

confidence: 99%

NOD1/CARD4(G796A) and NOD2/CARD15(R702W, G908R and L1007fsinC) polymorphisms associated with Crohn's disease in Iraqi patients

Sameer

Barraj

Mahmood³

2022

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Inflammatory bowel disease (IBD) applies to two main forms of chronic relapsing inflammatory intestinal disorders: Crohn's disease (CD), Ulcerative colitis (UC). CD requires an irregular immune reaction that induces intense inflammation. The cause of CD disease is not yet fully known; previous research, however, indicated inflammation of the intestines elevated or continues due to inappropriate immune responses due to associations between genetic factors, intestinal microbiota, and environmental factors contributing to the production of IBD. This study aimed to investigate predisposing genes, single nucleotide Polymorphisms (SNPs) NOD1/CARD4 and NOD2/CARD15) with CD in Iraqi patients. The common NOD1 (G796A) SNP and NOD2 SNPs R702W, G908R and L1007fsinC for NOD2 SNPs were selected. Thirty Iraqi citizens with a recognized diagnosis of CD and twenty apparently healthy controls were included in the study from November 2019 to December 2020; the common NOD1 and NOD2 polymorphisms have been screened by the polymerase chain reaction/restriction analysis length polymorphism (PCR/RFLP). The results of the current investigation for NOD1 polymorphism in studied patients and controls, the allelic and genotypic data show a highly significant association of G796A SNPs in the NOD1 with Crohn's disease, GA percentage was 56.67% in patients as compared to controls genotype was (0.00%). Furthermore, the G allele was more common in Crohn's patients than the A allele 0.72 vs. 0.28. Also, the allelic and genotypic frequency distribution of the studied NOD2 SNPs in the current study were (R702W, G908R, and L1007fs) in Iraqi patients, and controls revealed a highly significant connection between the G908R SNP with Crohn's disease susceptibility. The proportion of the genotype GC was 30% in patients while 0% in the control group, the frequency of the G allele was 0.85 vs 0.15 respectively, which was more than the frequency of the A allele. There were no significant changes in genotypic and allelic frequencies of the R702W and L1007fs SNPs in Iraqi Crohn's disease patients. The present study concluded that the NOD1 SNP of allelic and genotypic data show a highly significant association of G796A with a predisposition to Crohn's disease in Iraqi patients. And the NOD2 SNPs of G908R were also revealed to be highly effective. While the other studied SNPs were R702W and L1007fsinsC of NOD2, which showed no significant changes in the allelic and genotypic frequencies of the SNPs with Crohn's disease Iraqi patients. Keywords: Inflammatory bowel disease, Crohn's disease, NOD1/CARD4, NOD2/CARD15, polymorphisms.

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An update on the evaluation and management of iron deficiency anemia in inflammatory bowel disease

Cited by 7 publications

References 12 publications

Anemia and Iron Deficiency in Inflammatory Bowel Disease Patients in a Referral Center in Brazil: Prevalence and Risk Factors

Anemia and Iron Deficiency in Inflammatory Bowel Disease Patients in a Referral Center in Brazil: Prevalence and Risk Factors

Response: An Economic Evaluation of Iron Isomaltoside 1000 Versus Ferric Carboxymaltose in Patients with Inflammatory Bowel Disease and Iron Deficiency Anemia in Denmark

NOD1/CARD4(G796A) and NOD2/CARD15(R702W, G908R and L1007fsinC) polymorphisms associated with Crohn's disease in Iraqi patients

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