An update on the global use of risk assessment models and thromboprophylaxis in hospitalized patients with medical illnesses from the World Thrombosis Day steering committee: Systematic review and meta‐analysis

Forgó, Gábor; Micieli, Evy; Ageno, Walter; Castellucci, Lana A; Cesarman‐Maus, Gabriela; Ddungu, Henry; Paula, Erich Vinícius De; Dumantepe, Mert; Guillermo, Cecilia; Konstantinides, Stavros; Kucher, Nils; McLintock, Claire; Áinle, Fionnuala Ní; Spyropoulos, Alex C.; Urano, Tetsumei; Hunt, Beverley J.

doi:10.1111/jth.15607

Cited by 31 publications

(41 citation statements)

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“…Adequacy of thromboprophylaxis has been poorly addressed across studies. 2 Furthermore, there has been a wide inconsistency of the definition in studies and guidelines. 3 , 4 , 5 , 6 The ACCP guideline has proposed three main attributes for appropriate thromboprophylaxis 4 : (i) Patients at increased VTE risk should receive pharmacological thromboprophylaxis at an appropriate dosage; (ii) patients at low risk for VTE should not receive pharmacological thromboprophylaxis; (iii) patients at high risk of VTE and high risk of bleeding should receive mechanical thromboprophylaxis.…”

Section: Adequacy Of Thromboprophylaxismentioning

confidence: 99%

“… 1 , 2 Although most VTE events occurring during hospitalization are not associated with symptoms and their clinical impact is probably not substantial, about 65% of the events may be preventable by appropriate thromboprophylaxis. 1 , 2 Despite this, institution of thromboprophylaxis is still unsatisfactory among hospitalized patients with marked geographic differences. 1 , 2 …”

Section: Introductionmentioning

confidence: 99%

“… 1 , 2 Despite this, institution of thromboprophylaxis is still unsatisfactory among hospitalized patients with marked geographic differences. 1 , 2 …”

Section: Introductionmentioning

confidence: 99%

“…However, some concepts employed are imprecise or not appropriately defined. 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 The aim of this article is to highlight these issues as well as the unmet definitions in thromboprophylaxis in hospitalized patients based on selected RCTs and guidelines.…”

Section: Introductionmentioning

confidence: 99%

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Unmet definitions in thromboprophylaxis for hospitalized medical patients: An appraisal for the need of recommendation

Ferreira

Bastos

Rezende

2022

Research and Practice in Thrombosis and Haemostasis

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Up to about 60% of venous thromboembolic events in a community are associated with hospitalization, and most can be prevented by appropriate thromboprophylaxis. Several randomized clinical trials and guidelines have addressed the issue of thromboprophylaxis in hospitalized patients and recommended strategies to assess patients' risk and thromboprophylaxis. Simple and validated risk assessment models are available to assist physicians in selecting patients who are at high risk for VTE, in whom thromboprophylaxis should be used. However, some concepts employed are imprecise or not appropriately defined. Indeed, there has been wide variation in the onset, duration, and adequacy of thromboprophylaxis, as well as in the definition of some risk factors. In this article, we highlight these issues and the unmet definitions in thromboprophylaxis in hospitalized patients mainly by addressing selected randomized clinical trials and guidelines.

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Section: Adequacy Of Thromboprophylaxismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“… 1 , 2 Despite this, institution of thromboprophylaxis is still unsatisfactory among hospitalized patients with marked geographic differences. 1 , 2 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Unmet definitions in thromboprophylaxis for hospitalized medical patients: An appraisal for the need of recommendation

Ferreira

Bastos

Rezende

2022

Research and Practice in Thrombosis and Haemostasis

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show abstract

“… 21 A systematic review and meta-analysis showed that from 50.5% of patients with an indication to thromboprophylaxis, 54.5% had received adequate thromboprophylaxis, and bleeding, thrombocytopenia, and renal/hepatic failure were commonly specified contraindications to thromboprophylaxis. 22 Hence, we aimed to assess VTE risk, thromboprophylaxis practice, and outcomes using the Padua prediction score (PPS) in hospitalized medical patients at Tibebe Ghion Specialized Hospital (TGSH).…”

Section: Introductionmentioning

confidence: 99%

Incidence of thromboembolism and thromboprophylaxis in medical patients admitted to specialized hospital in Ethiopia using Padua prediction score

et al. 2022

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Introduction: Venous thromboembolism is a major cause of mortality and morbidity among hospitalized patients and thromboprophylaxis is one of the key strategies to reduce such events. We aimed to assess venous thromboembolism risk using Padua prediction score, thromboprophylaxis practice, and outcomes in hospitalized medical patients at Tibebe Ghion Specialized Hospital, Bahir Dar, Ethiopia. Methods: A cross-sectional study was conducted among 219 patients admitted to Tibebe Ghion Specialized Hospital from 1 December 2018 to 31 May 2019. Data were collected from patients’ medical records using a pre-tested data abstraction format to collect patients’ clinical information and venous thromboembolism risk using the Padua prediction score. We used Statistical Package for the Social Sciences version 26 for data analysis. Descriptive statistics was used to summarize the findings, and binary logistic regression analysis was used to assess association between the variables of interest. Results: Reduced mobility, recent trauma and/or surgery, heart and/or respiratory failure, and active cancer were the frequently identified venous thromboembolism risk factors. Based on Padua prediction score, 48.4% of patients were at high risk of developing venous thromboembolism. The venous thromboembolism prophylaxis was given only for 55 (25.1%) patients and 15 of them were at low risk of developing venous thromboembolism (<4 Padua score) and were ineligible for thromboprophylaxis. Fifteen (6.84%) patients developed venous thromboembolism events during their stay at the hospital and 80% of them were from high risk group. The odds of females to develop venous thromboembolism were more than 14 times higher (adjusted odds ratio = 14.51; 95% confidence interval: 2.52–83.39, p = 0.003) than males. Reduced mobility (adjusted odds ratio = 10.00; 95% confidence interval: 1.70–58.70), <1 month trauma and/or surgery (adjusted odds ratio = 18.93; 95% confidence interval: 2.30–155.56), active cancer (adjusted odds ratio = 6.00; 95% confidence interval: 1.05–34.27), chronic kidney diseases (adjusted odds ratio = 61.790; 95% confidence interval: 2.627–1453.602), and hypertension (adjusted odds ratio = 7.270; 95% confidence interval: 1.105–47.835) were significantly associated with the risk of developing venous thromboembolism. Conclusion: Nearly half of the patients were at risk of developing venous thromboembolism. Underutilization of thromboprophylaxis and inappropriate use of prophylaxis were commonly seen in Tibebe Ghion Specialized Hospital.

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Extended thromboprophylaxis in heart failure patients; the unmet need

Al Yami,

Alshehri,

Alay

et al. 2024

Heart Fail Rev

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An update on the global use of risk assessment models and thromboprophylaxis in hospitalized patients with medical illnesses from the World Thrombosis Day steering committee: Systematic review and meta‐analysis

Cited by 31 publications

References 50 publications

Unmet definitions in thromboprophylaxis for hospitalized medical patients: An appraisal for the need of recommendation

Unmet definitions in thromboprophylaxis for hospitalized medical patients: An appraisal for the need of recommendation

Incidence of thromboembolism and thromboprophylaxis in medical patients admitted to specialized hospital in Ethiopia using Padua prediction score

Extended thromboprophylaxis in heart failure patients; the unmet need

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