Objective: The relevance and use of Muscle Energy Technique (MET) as a mode of treatment for Non-specific low back pain (NSLBP) over the last two decades has increased among physiotherapists and other health professionals. This supports the clinical relevance and efficacy of this technique. However, there are no studies to determine the level of MET knowledge among Nigerian physiotherapists. This study was designed to determine the MET knowledge among Nigerian physiotherapists.Method: A total of one hundred and twenty physiotherapists were recruited from the database of the Nigerian Society of Physiotherapy and participated in the study. They completed a semi-structured questionnaire containing 46-items. This was divided into four sections which sourced information on sociodemographic characteristics, work-profile, treatment activities and the knowledge of MET for the management of NSLBP. Data were analyzed using descriptive statistics for mean, frequency and percentages. Inferential statistics of Chi-square, Pearson Correlation, independent t-test and ANOVA were used to determine the significant difference with significance set at p<0.05.Result: The study revealed that 16.7% of the participants had knowledge of the application of MET in the management for NSLBP. Age, educational level, practice setting, area of specialization such as musculoskeletal therapy, ergonomics and additional training of low back pain (LBP) were factors that influenced respondents’ MET knowledge (p<0.05). However, gender, university of training, number of years of experience and the practice of managing of LBP in the physiotherapy department did not influence knowledge of MET for the management of NSLBP (p >0.05).Conclusion: This study showed that a small number of participants had knowledge of MET application in the management of NSLBP and certain factors influenced this knowledge. Keywords: Non-specific low back pain, Muscle Energy Technique, Physiotherapists knowledge, Nigeria