An update on the role of the sebaceous gland in the pathogenesis of acne

Makrantonaki, Evgenia; Gancevičienė, Rūta; Zouboulis, Christos C.

doi:10.4161/derm.3.1.13900

Cited by 235 publications

(208 citation statements)

References 102 publications

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“…Some observations of twins, family of the first link confirmed that the presence of acne among relatives of the first team -especially mothers -has a strong influence on the age during the onset of the disease, course severity and success of treatment [6,8]. The heredity in almost 80% of first-degree relatives of patients with acne was determined.…”

Section: Problem Statement and Analysis Of The Recent Researchmentioning

confidence: 69%

Study of psycho-emotional state of patients with acne depending on the severity and hereditary factors

Petrenko

Litus

2017

Galician med. j.

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Acne is one of the most common skin disease in young adults and occurs in 85% of boys and girls. The disease is characterized by progressive course of the formation of psycho-emotional disorders, mainly depression row in about half of patients. Installed heredity is almost 80% of first-degree relatives of patients with acne. In patients with positive family history of acne the disease occurs earlier and course harder. The aim of the study -is to determine the impact of acne on psycho-emotional status in patients. Materials and methods. We examined 78 patients with severe and moderate acne. All patients were questioned by questionnaire CADI (Cardiff Acne Disability Index). Results. Among the surveyed men with moderate acne average value was 6, median -6, mode -6; in men with severe acne course average value was 8.6, median -9.5, mode -10. Among women surveyed the results of the form were somewhat different from data that were shown by male patients. Women with moderate acne had average value 7 points, the median -7.5 mode -8; among women who had severe acne course the average value was -8, median -9. Conclusions. As can be seen from the results of the questionnaire, respondents in all groups were shown a significant effect of disease on the psycho-emotional state of patients. Problem statement and analysis of the recent researchAmong noninfectious chronic inflammatory dermatoses acne occupies an exceptional position. Acne is one of the most common skin diseases in young adults and occurs in 85% of young people aged from 12 to 20 years, but the incidence peak falls at 16 years of age. Recently, a marked tendency to increase the number of women older than 25 years, in whom in 20-40% of cases occur in adult or acne tarda, which require an individual approach to the administration of therapy [1, 2].The disease is characterized by progressive course, the formation of psycho-emotional disorders, mainly of depression row, about in half of the patients (because of persistent disease for decades due to inadequate therapy), dramatically reduces the quality of life of patients. Severe forms that lead to complex cosmetic defects and the formation of hypo-and hypertrophic scars are from 5 to 15% of all cases of acne. Acne can cause psychological distress associated with many psychiatric conditions, which include suicidal thoughts, psychiatric problems and isolation from others [10]. 30-50% of adolescents experience psychological distress associated with acne: assessment of image, communication difficulties, social misadaption, destruction of hopes, anxiety, depression, low self-esteem [13]. However, there are works, which state that young male acne patients do not suffer from depressive symptoms; the risk of suicide is not greater than in the population [12].In the crossover study 108 patients with three dermatological diseases (acne, psoriasis, atopic dermatitis) in general and dermatological medicinal attendances were examined for the presence of minimal psychological disorders (anxiety, depression, social consciou...

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Section: Problem Statement and Analysis Of The Recent Researchmentioning

confidence: 69%

Study of psycho-emotional state of patients with acne depending on the severity and hereditary factors

Petrenko

Litus

2017

Galician med. j.

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“…Seborrhea, overproduction of sebum, is for the woman not only an aesthetic problem (shiny skin, oily, greasy), but also a predisposing factor to the most annoying and pathological disorder, such as the presence of comedones, development of acne vulgaris or other types of infectious diseases of the skin [71]. The overproduction of sebum is due to abnormal stimulation of the sebaceous glands induced by overproduction of androgens.…”

Section: Seborrhea and Acnementioning

confidence: 99%

Polycystic Ovary Syndrome: Features, Diagnostic Criteria and Treatments

G¹

2014

Endocrinol Metab Synd

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Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorder that affects 6-15% of the female population. It is a very complex syndrome that involves the hypothalamus, the pituitary gland, the ovaries, the adrenal gland and the peripheral adipose tissue that together contribute to create a generally imbalance, associated with three characteristic symptoms: oligo-anovulation, hirsutism and infertility. PCOS has been studied over a prolonged period of time and yet is still not fully understood. In

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“…Collagen destruction is thought to underlie the appearance of aged skin and changes resulting from chronic sun exposure (1). Ultraviolet irradiation from the sun has deleterious effects on human skin, including cancer and premature ageing (photoageing) (2). In addition, UVB induced the production of matrix metalloproteinase (MMPs) by activating cellular signalling transduction pathways (3).…”

Section: Accepted For Publication 26 April 2012mentioning

confidence: 99%

Reduced size of sebaceous gland and altered sebum lipid composition in mice lacking fatty acid binding protein 5 gene

Sugawara¹,

Nemoto

Adachi

et al. 2012

Experimental Dermatology

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Fatty acid binding proteins (FABPs) are capable of binding long‐chain FA and are involved in intracellular FA transport and signal transduction. In sebaceous glands, FABP5 is highly expressed in differentiated sebocytes; though, its function remains unclear. In this study, we examined the role of FABP5 in sebocytes using FABP5‐deficient mice. The size of sebaceous glands was significantly reduced, while the sebum volume was increased with altered lipid composition in FABP5‐deficient mice. However, no significant differences were discerned in the expression of proliferation or differentiation markers including Blimp1, c‐myc, Ki67 and peroxisome proliferator‐activated receptors (PPAR)γ between wild‐type and FABP5‐deficient sebaceous glands. The expression of cellular retinoic acid binding protein‐2 (CRABP2) that is a competitor of FABP5 for RA signalling was increased in FABP5‐deficient mice. These results suggest that FABP5 is involved in the regulation of sebaceous gland activity through modulation of cellular lipid signalling and/or metabolism in the sebocytes.

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An update on the role of the sebaceous gland in the pathogenesis of acne

Cited by 235 publications

References 102 publications

Study of psycho-emotional state of patients with acne depending on the severity and hereditary factors

Study of psycho-emotional state of patients with acne depending on the severity and hereditary factors

Polycystic Ovary Syndrome: Features, Diagnostic Criteria and Treatments

Reduced size of sebaceous gland and altered sebum lipid composition in mice lacking fatty acid binding protein 5 gene

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