An updated clinical and epidemiological profile of the adenomatoid odontogenic tumour: a collaborative retrospective study

Abstract

This updated review based on the largest number of AOT cases ever presented, confirms the distinctive, although not pathognomonic clinicopathological profile of the AOT, its worldwide occurrence, and its consistently benign behaviour.

Adenomatoid Odontogenic Tumor: Retrospective Study of 15 Cases with Emphasis on Histopathologic Features

“…It has been generally reported that AOT corresponds to 2.2-8.7 % of all odontogenic tumors [2,10,19]. However, in a worldwide collaborative retrospective study, the relative frequency of AOT ranged from 0.6 to 38.5 % [4]. Interestingly, the highest percentages were found in studies from Nigeria, which might suggest geographic differences in the frequency of these tumors [4].…”

“…However, in a worldwide collaborative retrospective study, the relative frequency of AOT ranged from 0.6 to 38.5 % [4]. Interestingly, the highest percentages were found in studies from Nigeria, which might suggest geographic differences in the frequency of these tumors [4]. Nonetheless, it must be emphasized that the recent inclusion of odontogenic keratocysts in the group of odontogenic tumors [20] may make in some instances a marked impact on the reported relative frequency of AOT [4].…”

“…The AOT is a benign odontogenic lesion that has been regarded either as a non-aggressive, non-invasive neoplasm or as a developmental hamartomatous growth [4,18]. It has been generally reported that AOT corresponds to 2.2-8.7 % of all odontogenic tumors [2,10,19].…”

“…Credit has been giving to Harbiz [3] for reporting the earliest case demonstrating irrefutable proof of an AOT, in 1915. On the other hand, Stafne, in 1948, was the first author who considered AOT as an entity although he did not propose a specific name for it [4]. In 1969, Philipsen and Birn [5] introduced the term 'adenomatoid odontogenic tumor', to be adopted by the World Health Organization (WHO) classification of odontogenic tumors in 1971 [6], and it is now the generally accepted nomenclature.…”

“…Despite the relatively large number of studies about demographic, clinical and radiologic features of AOT [4,7,9,11,12], information regarding the frequency of the many histopathologic aspects of this lesion is scarce [8,13,14]. Thus, the aim of this study was to perform a retrospective analysis in a case series of AOT, with emphasis on the histopathological features, in order to provide useful additional data to the literature.…”