An Updated Meta-Analysis of the Associations Between MicroRNA Polymorphisms and Susceptibility to Rheumatoid Arthritis

Zhou, Mi; Jiang, Bo; Mao, Xiong; Zhu, Xin

doi:10.3389/fphys.2018.01604

Cited by 13 publications

(5 citation statements)

References 40 publications

(61 reference statements)

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“…A novel approach employing -omics tools is measuring micro-(small non-coding) RNA’s, which can bind to mRNA, thereby influencing gene expression. However, limited data to disease relevance are available, though susceptibility to RA was shown in a meta-analysis [ 299 ], and their potential role for other diseases, such as neurodegenerative ones an the related interplay to OS have been reviewed [ 300 ].…”

Section: Markers Of Os Relation To Disease and Practical Aspectsmentioning

confidence: 99%

Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?

Menzel¹,

Samouda

Dohet³

et al. 2021

Antioxidants

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Many chronic conditions such as cancer, chronic obstructive pulmonary disease, type-2 diabetes, obesity, peripheral/coronary artery disease and auto-immune diseases are associated with low-grade inflammation. Closely related to inflammation is oxidative stress (OS), which can be either causal or secondary to inflammation. While a low level of OS is physiological, chronically increased OS is deleterious. Therefore, valid biomarkers of these signalling pathways may enable detection and following progression of OS/inflammation as well as to evaluate treatment efficacy. Such biomarkers should be stable and obtainable through non-invasive methods and their determination should be affordable and easy. The most frequently used inflammatory markers include acute-phase proteins, essentially CRP, serum amyloid A, fibrinogen and procalcitonin, and cytokines, predominantly TNFα, interleukins 1β, 6, 8, 10 and 12 and their receptors and IFNγ. Some cytokines appear to be disease-specific. Conversely, OS—being ubiquitous—and its biomarkers appear less disease or tissue-specific. These include lipid peroxidation products, e.g., F2-isoprostanes and malondialdehyde, DNA breakdown products (e.g., 8-OH-dG), protein adducts (e.g., carbonylated proteins), or antioxidant status. More novel markers include also –omics related ones, as well as non-invasive, questionnaire-based measures, such as the dietary inflammatory-index (DII), but their link to biological responses may be variable. Nevertheless, many of these markers have been clearly related to a number of diseases. However, their use in clinical practice is often limited, due to lacking analytical or clinical validation, or technical challenges. In this review, we strive to highlight frequently employed and useful markers of inflammation-related OS, including novel promising markers.

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Section: Markers Of Os Relation To Disease and Practical Aspectsmentioning

confidence: 99%

Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?

Menzel¹,

Samouda

Dohet³

et al. 2021

Antioxidants

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“…SNPs in the miRNA binding sites can alter miRNA-mRNA binding affinity, which alters expression of the corresponding genes, thereby affecting cell proliferation, apoptosis and development. This process is associated with susceptibility to diseases, including cancer and autoimmune diseases (20,28,29). Here, SNP rs16917496 in the miR-502 binding site of the 3'-UTR of SET8 mRNA was associated with the occurrence of RA; low SET8 and higher ROS levels and decreased IL-10 expression were associated with CC genotype and increased risk of RA.…”

Section: Discussionmentioning

confidence: 91%

Polymorphisms in microRNA binding site of SET8 regulate the risk of rheumatoid arthritis

et al. 2023

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Rheumatoid arthritis (RA) is a complex, heterogeneous, progressive and long-term autoimmune disease characterized by symmetrical joint inflammation and bone erosion. The etiology of RA is unclear, but its pathogenesis is associated with oxidative stress and inflammatory cytokines. Single nucleotide polymorphisms (SNPs) in the microRNA (miRNA)-binding sites modify the development of rheumatic disease by regulating the expression of target genes. The present study investigated whether SNPs in the miRNA binding site in the 3' untranslated region (3'-UTR) of SET domain containing lysine methyltransferase) 8 (SET8) and Keratin 81 (KRT81), namely rs16917496 and rs3660, respectively, were associated with the occurrence of RA. The polymerase chain reaction-ligase detection reaction assay showed that the distribution frequencies of the CC genotype (P=0.025) of SNP rs16917496 in SET8 were significantly higher in patients with RA than in healthy controls, which indicated that the CC genotype was associated with an increased risk of RA. SET8 expression in the blood samples of CC genotype carriers was lower than that of TT genotype carriers. Moreover, the CC genotype carriers exhibited higher reactive oxygen species (ROS) levels (1011.500±536.426 vs. 548.616±190.508, P=0.032) and lower interleukin-10 (IL-10) levels (P<0.001). The present study demonstrated that SNP rs16917496 in the 3'-UTR of SET8 was a predictor of RA risk and may regulate RA development by mediating expression of SET8, thereby regulating the levels of ROS and IL-10.

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“…In a further study on the same SNP rs3746444 conducted on Han Chinese [22], there was no association when tested; however, the finding indicated that CT genotype increases the level of anti-CCP antibody which increases the risk of RA. Other studies showed a variation in associations; for example, in [21] Zhou et. al.…”

Section: Discussionmentioning

confidence: 97%

A genetic study of the association of six polymorphisms with rheumatoid arthritis in the Egyptian population

Ibrahim

Hassan

Saad

et al. 2022

Egypt J Med Hum Genet

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Background Rheumatoid arthritis (RA) is an autoimmune disease in which the immune system attacks the tissues of the joints by mistake. Different factors—either genetic or environmental—affect the development of the RA disease in patients. A lot of studies aimed to examine the genetic associations with this disease in different populations. This research aspires to perform a genetic association study between six single-nucleotide polymorphisms (SNPs) and RA disease in the Egyptian population with 49 controls and 52 patients. The SNPs that are included in this study are MIR146A rs2910164 (C:G), MIR499/MIR499A rs3746444 (T:C), MTMR3 rs12537(C:T), MIR155HG rs767649 (A:T), IRAK1 rs3027898 (A:C) and PADI4 rs1748033 (C:T). Methods Real-time PCR with TaqMan allelic discrimination assay were both used to perform the genotyping. The Odds ratio models with 95% confidence interval were used to test the associations. The used models are multiplicative, recessive, dominant and co-dominant. Result The demonstrated results indicated that rs2910164 and rs12537 were associated with RA, while rs3746444 showed no association in all the tested models. The remaining SNPs were excluded as they didn't pass the Hardy–Weinberg equilibrium test. Conclusion The MIR146A and MTMR3 polymorphisms showed susceptibility to RA. Moreover, MIR499/MIR499A had no role in the disease.

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An Updated Meta-Analysis of the Associations Between MicroRNA Polymorphisms and Susceptibility to Rheumatoid Arthritis

Cited by 13 publications

References 40 publications

Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?

Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?

Polymorphisms in microRNA binding site of SET8 regulate the risk of rheumatoid arthritis

A genetic study of the association of six polymorphisms with rheumatoid arthritis in the Egyptian population

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