An Updated Meta-Analysis on the Effectiveness of Preoperative Prophylactic Antibiotics in Patients Undergoing Breast Surgical Procedures

Sajid, M. S.; Hutson, Kristian; Akhter, Naved; Kalra, L.; Rapisarda, I.F.; Bonomi, Ricardo

doi:10.1111/j.1524-4741.2012.01248.x

Cited by 27 publications

(10 citation statements)

References 36 publications

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“…Two systematic reviews by Bunn et al and Sajid et al investigated a total of 15 randomized controlled trials involving oncologic breast surgery and concluded that prophylactic antibiotics may be routinely given. 24,35 Although surgical technique may differ, these principles should be applied to mammaplasty.…”

Section: Discussionmentioning

confidence: 99%

Are Systemic Antibiotics Indicated in Aesthetic Breast Surgery? A Systematic Review of the Literature

Hardwicke

Bechar²,

Skillman³

2013

Plastic &Amp; Reconstructive Surgery

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Section: Discussionmentioning

confidence: 99%

Are Systemic Antibiotics Indicated in Aesthetic Breast Surgery? A Systematic Review of the Literature

Hardwicke

Bechar²,

Skillman³

2013

Plastic &Amp; Reconstructive Surgery

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“…1–4 Perioperative prophylactic antibiotics, given in accordance with Joint Commission SCIP (Surgical Care Improvement Project) guidelines, significantly reduce the risk of SSI after breast surgery but the value of postoperative prophylactic antibiotics is largely unknown. 5–8 Surgeon practices regarding routine postoperative antibiotic use are mixed. 2,3,9 In a study by Brahmbhatt, 16 % of surveyed surgeons responded that they always/almost always prescribed postoperative prophylactic antibiotics while 76 % never/almost never prescribed antibiotics beyond the 24-hour postoperative period in the setting of no reconstruction.…”

mentioning

confidence: 99%

Use of Prophylactic Postoperative Antibiotics During Surgical Drain Presence Following Mastectomy

et al. 2014

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Background National guidelines recommend one dose of perioperative antibiotics for breast surgery and discourage postoperative continuation. However, reported skin and soft tissue infection (SSI) rates after mastectomy range from 1–26 %, higher than expected for clean cases. Utility of routine or selective postoperative antibiotic use for duration of drain presence following mastectomy remains uncertain. Methods This study included all female patients who underwent mastectomy without reconstruction at our institution between 2005 and 2012. SSI was defined using CDC criteria or clinical diagnosis of cellulitis. Information on risk factors for infection (age, body mass index [BMI], smoking status, diabetes, steroid use), prior breast cancer treatment, drain duration, and antibiotic use was abstracted from medical records. Multivariable logistic regression was used to assess the association between postoperative antibiotic use and the occurrence of SSI, adjusting for concurrent risk factors. Results Among 480 patients undergoing mastectomy without reconstruction, 425 had sufficient documentation for analysis. Of these, 268 were prescribed antibiotics (63 %) at hospital discharge. An overall SSI rate of 7.3 % was observed, with 14 % of patients without postoperative antibiotics developing SSI compared with 3.4 % with antibiotics (p < 0.0001). Factors independently associated with SSI were smoking and advancing age. Diabetes, steroid use, BMI, prior breast surgery, neoadjuvant chemotherapy, prior radiation, concomitant axillary surgery, and drain duration were not associated with increased SSI rates. Conclusions SSI rates among patients who did and did not receive postoperative antibiotics after mastectomy were significantly different, particularly among smokers and women of advanced age. These patient subgroups may warrant special consideration for postoperative antibiotics.

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“…92e94 Preoperative prophylactic antibiotics are useful for preventing surgical site infection in patients undergoing breast surgery. 95 The most commonly used antibiotics are penicillins with antistaphylococcal activities, first-generation cephalosporins, and betalactam/beta-lactamase inhibitor combinations; patients with beta-lactam allergy generally receive macrolides or clindamycin. The role of postoperative antibiotic prophylaxis in breast augmentation surgery is more contentious.…”

Section: Breast Augmentation Proceduresmentioning

confidence: 99%

Infections associated with body modification

Wong

Wong²,

Yuen³

2012

Journal of the Formosan Medical Association

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Although exact statistics are lacking, body modifications for cosmetic purposes are performed in many countries. The commonest forms include tattooing, body piercing, and breast and facial augmentation using implants or injectable fillers. Liposuction and, to a lesser extent, mesotherapy are also practiced in many countries. Infective complications of these procedures include local infections, transmission of bloodborne pathogens (viral hepatitis and human immunodeficiency virus), and distant infections such as infective endocarditis. Presence of foreign bodies, long healing time of piercing wounds, and poor compliance with infection control practices of some practitioners all predispose the recipients to infections. Apart from the endogenous microbial flora of the skin and mucosae, atypical mycobacteria, especially the rapid growers, have emerged as some of the most important pathogens in such settings. Outbreaks of infection are commonly reported. We hereby review the current knowledge of the topic with specific focus on infections associated with tattooing, body piercing, breast augmentation, mesotherapy, liposuction, and tissue filler injections. Greater awareness among consumers and health-care professionals, as well as more stringent regulations by the health authorities, is essential to minimize the health risks arising from these procedures.

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An Updated Meta-Analysis on the Effectiveness of Preoperative Prophylactic Antibiotics in Patients Undergoing Breast Surgical Procedures

Cited by 27 publications

References 36 publications

Are Systemic Antibiotics Indicated in Aesthetic Breast Surgery? A Systematic Review of the Literature

Are Systemic Antibiotics Indicated in Aesthetic Breast Surgery? A Systematic Review of the Literature

Use of Prophylactic Postoperative Antibiotics During Surgical Drain Presence Following Mastectomy

Infections associated with body modification

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