An updated overview on metal nanoparticles toxicity

Medici, Serenella; Peana, Massimiliano; Pelucelli, Alessio; Zoroddu, Maria Antonietta

doi:10.1016/j.semcancer.2021.06.020

Cited by 141 publications

(71 citation statements)

References 122 publications

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“…Nanoparticles have been found and produced in large numbers, but conventional criteria for limiting exposure and assessing their potential toxicity are lacking (Medici et al., 2021 ). Toxic effects are possible despite the particular advantages of nanomaterials due to their tiny size and high surface area which have been shown to boost reactivity with biological targets.…”

Section: Risk Factors Involved In the Clinical Application Of Metal N...mentioning

confidence: 99%

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Metal nanoparticles as a promising technology in targeted cancer treatment

et al. 2022

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Traditional anticancer treatments have several limitations, but cancer is still one of the deadliest diseases. As a result, new anticancer drugs are required for the treatment of cancer. The use of metal nanoparticles (NPs) as alternative chemotherapeutic drugs is on the rise in cancer research. Metal NPs have the potential for use in a wide range of applications. Natural or surface-induced anticancer effects can be found in metals. The focus of this review is on the therapeutic potential of metal-based NPs. The potential of various types of metal NPs for tumor targeting will be discussed for cancer treatment. The in vivo application of metal NPs for solid tumors will be reviewed. Risk factors involved in the clinical application of metal NPs will also be summarized.

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Section: Risk Factors Involved In the Clinical Application Of Metal N...mentioning

confidence: 99%

“… Exposure routes, ways of uptake, translocation, and distribution of NPs into the human body (Medici et al., 2021 ). …”

Section: Risk Factors Involved In the Clinical Application Of Metal N...mentioning

confidence: 99%

Metal nanoparticles as a promising technology in targeted cancer treatment

et al. 2022

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“…The agglomeration state also plays a vital role in their toxicity, since it can contribute to the sedimentation process and reduce the diffusion of MNPs, resulting in higher effective doses and organ deposition. When applied in materials, agglomeration can promote the non-uniform distribution of MNPs, resulting in materials with poor reproducibility and compromised properties [ 161 , 162 ]. The charge of MNPs presents an essential function in regulating protein binding to MNPs, cellular uptake, oxidative stress, autophagy, inflammation, and apoptosis.…”

Section: Safety Issues Of Mnps and The Role Of Polysaccharidesmentioning

confidence: 99%

Polysaccharides and Metal Nanoparticles for Functional Textiles: A Review

et al. 2022

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Nanotechnology is a powerful tool for engineering functional materials that has the potential to transform textiles into high-performance, value-added products. In recent years, there has been considerable interest in the development of functional textiles using metal nanoparticles (MNPs). The incorporation of MNPs in textiles allows for the obtention of multifunctional properties, such as ultraviolet (UV) protection, self-cleaning, and electrical conductivity, as well as antimicrobial, antistatic, antiwrinkle, and flame retardant properties, without compromising the inherent characteristics of the textile. Environmental sustainability is also one of the main motivations in development and innovation in the textile industry. Thus, the synthesis of MNPs using ecofriendly sources, such as polysaccharides, is of high importance. The main functions of polysaccharides in these processes are the reduction and stabilization of MNPs, as well as the adhesion of MNPs onto fabrics. This review covers the major research attempts to obtain textiles with different functional properties using polysaccharides and MNPs. The main polysaccharides reported include chitosan, alginate, starch, cyclodextrins, and cellulose, with silver, zinc, copper, and titanium being the most explored MNPs. The potential applications of these functionalized textiles are also reported, and they include healthcare (wound dressing, drug release), protection (antimicrobial activity, UV protection, flame retardant), and environmental remediation (catalysts).

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“…One of the biggest challenges is to understand the behavior of nanoparticles in the environmental system, as it is known that the interaction between nanomaterials, the environment and the human body is complex and depends on the size and type of particle [149]. The literature has reported studies that specifically deal with the toxicity of nanoparticles, and this concern has been growing in recent years [150][151][152]. Therefore, immobilizing these nanostructured catalysts on supports has been the object of investigation, mainly due to the observed advantages, such as increased surface area and waste recovery for the production of catalytic supports [153,154].…”

Section: Relationship Between Nanotechnology and Sustainable Developmentmentioning

confidence: 99%

Conversion of Plastic Waste into Supports for Nanostructured Heterogeneous Catalysts: Application in Environmental Remediation

et al. 2021

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Plastics are ubiquitous in our society and are used in many industries, such as packaging, electronics, the automotive industry, and medical and health sectors, and plastic waste is among the types of waste of higher environmental concern. The increase in the amount of plastic waste produced daily has increased environmental problems, such as pollution by micro-plastics, contamination of the food chain, biodiversity degradation and economic losses. The selective and efficient conversion of plastic waste for applications in environmental remediation, such as by obtaining composites, is a strategy of the scientific community for the recovery of plastic waste. The development of polymeric supports for efficient, sustainable, and low-cost heterogeneous catalysts for the treatment of organic/inorganic contaminants is highly desirable yet still a great challenge; this will be the main focus of this work. Common commercial polymers, like polystyrene, polypropylene, polyethylene therephthalate, polyethylene and polyvinyl chloride, are addressed herein, as are their main physicochemical properties, such as molecular mass, degree of crystallinity and others. Additionally, we discuss the environmental and health risks of plastic debris and the main recycling technologies as well as their issues and environmental impact. The use of nanomaterials raises concerns about toxicity and reinforces the need to apply supports; this means that the recycling of plastics in this way may tackle two issues. Finally, we dissert about the advances in turning plastic waste into support for nanocatalysts for environmental remediation, mainly metal and metal oxide nanoparticles.

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An updated overview on metal nanoparticles toxicity

Cited by 141 publications

References 122 publications

Metal nanoparticles as a promising technology in targeted cancer treatment

Metal nanoparticles as a promising technology in targeted cancer treatment

Polysaccharides and Metal Nanoparticles for Functional Textiles: A Review

Conversion of Plastic Waste into Supports for Nanostructured Heterogeneous Catalysts: Application in Environmental Remediation

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