2023
DOI: 10.3390/cancers15245755
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An Updated Review on the Emerging Role of Indocyanine Green (ICG) as a Sentinel Lymph Node Tracer in Breast Cancer

Ioanna Akrida,
Nikolaos V. Michalopoulos,
Maria Lagadinou
et al.

Abstract: Sentinel lymph node biopsy (SLNB) has become the standard of care for clinically node-negative breast cancer and has recently been shown by clinical trials to be also feasible for clinically node-positive patients treated with primary systemic therapy. The dual technique using both radioisotope (RI) and blue dye (BD) as tracers for the identification of sentinel lymph nodes is considered the gold standard. However, allergic reactions to blue dye as well as logistics issues related to the use of radioactive age… Show more

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Cited by 7 publications
(1 citation statement)
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“…Since 2020, NIR-II image-guided surgery has been applied in clinics; the impressive outperformance strongly facilitates the research and application of NIR-II intraoperative imaging [ 28 , 29 ]. Although ICG offers a convenient approach to perform NIR-II imaging in various cancers, such as breast cancer, gynecological cancer [ 30 , 31 , 32 , 33 ], and digestive tract cancer [ 34 ], the unstable tumor retention might affect surgeons to accurately locate and resect tumors [ 33 , 35 ]. In order to address the diverse and multi-level clinical demands, taking into account the advantages of NIR-II imaging, the development of novel NIR-II optical probes for in vivo imaging represents an optimal choice.…”
Section: Discussionmentioning
confidence: 99%
“…Since 2020, NIR-II image-guided surgery has been applied in clinics; the impressive outperformance strongly facilitates the research and application of NIR-II intraoperative imaging [ 28 , 29 ]. Although ICG offers a convenient approach to perform NIR-II imaging in various cancers, such as breast cancer, gynecological cancer [ 30 , 31 , 32 , 33 ], and digestive tract cancer [ 34 ], the unstable tumor retention might affect surgeons to accurately locate and resect tumors [ 33 , 35 ]. In order to address the diverse and multi-level clinical demands, taking into account the advantages of NIR-II imaging, the development of novel NIR-II optical probes for in vivo imaging represents an optimal choice.…”
Section: Discussionmentioning
confidence: 99%