An updated systematic review of Health State Utility Values for osteoporosis related conditions

Peasgood, Tessa; Herrmann, K; Kanis, John А.; Brazier, John

doi:10.1007/s00198-009-0844-y

Cited by 122 publications

(87 citation statements)

References 46 publications

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“…The results presented here support previous research demonstrating that hip fractures are associated with a substantial decrement in HrQoL [11,[22][23][24]. In a systematic review, hip fractures were associated with a HrQoL decrement of approximately 50 % shortly after fracture and 20 % 4 months after fracture [23].…”

Section: Discussionsupporting

confidence: 89%

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The burden of osteoporotic hip fractures in Portugal: costs, health related quality of life and mortality

2015

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Summary The study rationale was to provide a detailed overview of the costs, quality of life and mortality of hip fractures in Portugal. Mean individual fracture-related costs were estimated at €13, 434 [12,290; 14,576] for the first year and €5985 [4982; 7045] for the second year following the fracture. Introduction Osteoporotic fractures represent a remarkable burden to health care systems and societies worldwide, which will tend to increase as life expectancy expands and lifestyle changes favour osteoporosis. The cost-effectiveness evaluation of intervention strategies demands accurate data on the epidemiological and economical reality to be addressed. Methods Information was collected retrospectively on consumption of resources and changes in quality of life attributable to fracture as well as mortality, regarding 186 patients randomly selected to represent the distribution of hip fractures in the Portuguese population, in terms of gender, age and geographical provenience. Data were cross-tabulated with socio-demographic variables and individual resource consumption to estimate the burden of disease. A societal perspective was adopted, including direct and indirect costs.Multivariate analyses were carried out to assess the main determinants of health-related quality of life (HrQoL). Results Mean individual fracture-related costs were estimated at €13, 434 [12,290; 14,576] for the first year and €5985 [4982; 7045] for the second year following the fracture. In 2011 the economic burden attributable to osteoporotic hip fractures in Portugal could be estimated at €216 million. Mean reduction in HrQoL 12 months after fracture was estimated at 0.34. Regression analysis showed that age was associated with a higher loss of HrQoL, whereas education had the opposing effect. We observed 12 % excess mortality in the first year after hip fracture, when compared to the gender and age-matched general population. Conclusions Results of this study indicate that osteoporotic hip fractures are, also in Portugal, despite its low incidence of fractures and cost per event, associated with a high societal burden, in terms of costs, loss in HrQoL and mortality. These data provide valuable input to the design and selection of fracture prevention strategies.

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Section: Discussionsupporting

confidence: 89%

“…In a systematic review, hip fractures were associated with a HrQoL decrement of approximately 50 % shortly after fracture and 20 % 4 months after fracture [23]. In our study, HrQoL values are close to the estimates found in others studies, with the exception of HrQoL 1 month after the event, which is remarkably lower in our case.…”

Section: Discussionsupporting

confidence: 88%

The burden of osteoporotic hip fractures in Portugal: costs, health related quality of life and mortality

2015

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“…16. [95,96] The clinical and cost-effectiveness of fracture liaison services has been demonstrated in several centres [97][98][99][100][101]. In an analysis of data collected over 8 years in Glasgow it was estimated that the service prevented 18 hip fractures and saved £21,000 per 1000 patients [102].…”

Section: Fracture Liaison Servicesmentioning

confidence: 99%

“…The health utility in the first year after hip, clinical vertebral and forearm fracture relative to the age-specific health utility in the normal population has been estimated at 0.70, 0.59 and 0.96, respectively [100]. Other fractures were assigned 85 % of the age specific health utility.…”

Section: Health Utility and Qaly Implications Of Fracturementioning

confidence: 99%

Osteoporosis in the European Union: medical management, epidemiology and economic burden

Hernlund¹,

Svedbom²,

Ivergård³

et al. 2013

Arch Osteoporos

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2,138

1,048

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Summary This report describes the epidemiology, burden, and treatment of osteoporosis in the 27 countries of the European Union (EU27). Introduction Osteoporosis is characterized by reduced bone mass and disruption of bone architecture, resulting in increased risk of fragility fractures which represent the main clinical consequence of the disease. Fragility fractures are associated with substantial pain and suffering, disability and even death for affected patients and substantial costs to society. The aim of this report was to characterize the burden of osteoporosis in the EU27 in 2010 and beyond. Methods The literature on fracture incidence and costs of fractures in the EU27 was reviewed and incorporated into a model estimating the clinical and economic burden of osteoporotic fractures in 2010.Results Twenty-two million women and 5.5 million men were estimated to have osteoporosis; and 3.5 million new fragility fractures were sustained, comprising 610,000 hip fractures, 520,000 vertebral fractures, 560,000 forearm fractures and 1,800,000 other fractures (i.e. fractures of the pelvis, rib, humerus, tibia, fibula, clavicle, scapula, sternum and other femoral fractures). The economic burden of incident and prior fragility fractures was estimated at € 37 billion. Incident fractures represented 66 % of this cost, long-term fracture care 29 % and pharmacological prevention 5 %. Previous and incident fractures also accounted for 1,180,000 quality-adjusted life years lost during 2010. The costs are expected to increase by 25 % in 2025. The majority of individuals who have sustained an osteoporosis-related fracture or who are at high risk of fracture are untreated and the number of patients on treatment is declining.

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“…Current annual healthcare costs associated with hip fractures are between 10.3 billion USD and 15.2 billion USD [8], and the incidence of hip fractures is expected to rise substantially as an increasing proportion of the population ages [3]. Hip fractures are associated with mortality ranging from 12% to 37% 1 year after surgery [8,15,16] and substantial compromises to the patients' quality of life [17]. There is a disparity in outcomes between male and female patients, with the former having a greater mortality rate at 1 year and being more likely to experience a postoperative complication [1,11,14].…”

Section: Introductionmentioning

confidence: 99%

Does a Multidisciplinary Team Decrease Complications in Male Patients With Hip Fractures?

Dossous

Ton

et al. 2011

Clinical Orthopaedics &Amp; Related Research

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Background Men with hip fractures are more likely to experience postoperative complications than women. The Medical Orthopaedic Trauma Service program at New York Presbyterian Hospital utilizes a multidisciplinary team approach to care for patients with hip fractures. The service is comanaged by an attending hospitalist and orthopaedic surgeon, with daily walking rounds attended by the hospitalist, orthopaedic resident, physical therapist, social worker, and a dedicated Medical Orthopaedic Trauma Service physician assistant. Questions/purposes We asked whether a multidisciplinary service for patients with hip fracture decreases (1) the incidence of inpatient complications in men, (2) the length of hospitalization, and (3) 90-day and 1-year mortality. Patients and Methods We retrospectively reviewed the charts of 74 men who had surgery for a nonperiprosthetic femoral neck, intertrochanteric, or subtrochanteric fracture for two 7-month periods before and after implementation of the Medical Orthopaedic Trauma Service. Age, ethnicity, comorbidity status, time to surgery, and postoperative complication data were collected. Regression modeling was used to evaluate the likelihood of postoperative complications, length of hospitalization, and 90-day and 1-year mortality while controlling for age, Charlson Comorbidity Index score, fracture type, and time from admission to surgery. Results We observed a decrease in the likelihood of experiencing at least one inpatient complication in male patients after implementation of the Medical Orthopaedic Trauma Service (odds ratio = 0.264). There was no difference in length of hospitalization, 90-day mortality, or 1-year mortality. Conclusions Multidisciplinary collaboration for patients with hip fractures can decrease the likelihood of experiencing inpatient complications in male patients.Each author certifies that he or she has no commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article. Each author certifies that his or her institution approved the human protocol for this investigation and that all investigations were conducted in conformity with ethical principles of research.

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An updated systematic review of Health State Utility Values for osteoporosis related conditions

Abstract: The paper provides a set of multipliers representing the loss in HSUVs for use as a "reference case" in cost-effectiveness models.

Cited by 122 publications

References 46 publications

The burden of osteoporotic hip fractures in Portugal: costs, health related quality of life and mortality

The burden of osteoporotic hip fractures in Portugal: costs, health related quality of life and mortality

Osteoporosis in the European Union: medical management, epidemiology and economic burden

Does a Multidisciplinary Team Decrease Complications in Male Patients With Hip Fractures?

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