An XRF study of trace elements accumulation in kidneys of tumor-bearing mice after treatment withcis-DDP with and without selenite and selenocistamine

Shenberg, C.; Boazi, M.; Cohen, Jacob; Klein, Abraham A.; M, Kojler; Nyska, Abraham

doi:10.1007/bf02950787

Cited by 11 publications

(4 citation statements)

References 4 publications

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“…In animals, treated with CP for tumours, increased levels of trace elements, for example, iron, copper, and zinc, in addition to platinum, were observed in the kidneys and liver. This suggested that platinum toxicity is due to an overall accumulation of trace elements in these organs and is attributable to platinum alone [6]. …”

Section: Introductionmentioning

confidence: 99%

Azadirachta indicaAttenuates Cisplatin-Induced Nephrotoxicity and Oxidative Stress

Moneim

Othman

Aref

2014

BioMed Research International

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We investigated the effects of methanolic leaves extract of Azadirachta indica (MLEN, 500 mg/kg bwt) on cisplatin- (CP-) induced nephrotoxicity and oxidative stress in rats. CP (5 mg/kg bwt) was injected intraperitoneally and MLEN was given by gastric gavage for 5 days before or after CP injection. After 5 days of CP injection, CP-induced injury of the renal tissue was evidenced (i) as histopathological damage of the renal tissue, (ii) as increases in serum uric acid, urea, and creatinine, (iii) as increases in malondialdehyde (MDA) and nitric oxide (NO), (iv) as decreases in the level of glutathione and activities of superoxide dismutase, catalase, glutathione reductase, glutathione-S-transferase, and glutathione peroxidase, and (v) as increase in the expression of nuclear factor kappa B and apoptosis in kidney tissues. However, the oral administration of MLEN to CP-intoxicated rats for 5 days brought back MDA, NO production, and enzymatic and nonenzymatic antioxidants to near normalcy. Moreover, the histological observations evidenced that neem extract effectively rescues the kidney from CP-mediated oxidative damage. Furthermore, PCR results for caspase-3 and caspase-9 and Bax genes showed downregulation in MLEN treated groups. Therefore, Azadirachta indica can be considered a potential candidate for protection of nephrotoxicity induced by cisplatin.

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Section: Introductionmentioning

confidence: 99%

Azadirachta indicaAttenuates Cisplatin-Induced Nephrotoxicity and Oxidative Stress

Moneim

Othman

Aref

2014

BioMed Research International

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“…In animals, treated with cisplatin for tumours, increased levels of trace elements, e.g., iron, copper, and zinc, in addition to platinum, were observed in the kidneys and liver (XRF technique with Mo X-ray tube and a SiLi detector). This suggested that platinum toxicity is due to an overall accumulation of trace elements in these organs and attributable to platinum alone (Shenberg et al , 1994). It has also been shown that trace element levels in blood, liver, and kidneys were different between tissue samples obtained from tumour mice and normal mice (Feldstein et al , 1998).…”

Section: Overview Of In Vitro Xrf Applications In Medicinementioning

confidence: 99%

Medical applications of X-ray fluorescence for trace element research

Börjesson¹,

Mattsson

2007

Powder Diffr.

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Techniques for estimation of element levels directly in humans (noninvasivein vivo) or in samples (in vitro) from humans are reviewed. Toxic, nonessential, trace elements may cause temporary or permanent damage to various organs and tissues in humans. There is thus a need to control the concentrations. Knowledge of the relations between toxic effects and element concentration may be extracted from measurements in humans as well as in samples from humans and her environment. Applications traditionally include occupationally exposed subjects, but an increasing research area is studies of members of the general population and of patients undergoing therapy for malignant and other diseases. Mostin vivoXRF studies deal with lead in bone and cadmium in kidneys. For retired lead workers, a clear association has been demonstrated between bone lead and blood lead, due to endogenous lead excretion from the skeleton. A study of mercuryin vivoshowed that the technique is capable of detecting mercury in heavily exposed worker’s kidneys.In vivoXRF in cancer and rheumatology patients has helped to understand how platinum and gold are retained in the human body. The newestin vivoapplications include zinc in prostate gland and arsenic in skin.

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“…Generally, DNA damaging agents have less toxicity on nonproliferating cells, yet the proximal tubule cells are selectively damaged by CIS because of its accumulation in the kidney to a greater extent compared to other organs [5]. Suggests that this injury is due to inflammation, oxidative stress and apoptosis [6].…”

Section: Introductionmentioning

confidence: 99%

Chemoprotective Effect of Noni (Morinda Citrifolia L.) Fruit Juice Against Cisplatin-Induced Nephrotoxicity

Ali

Mruthunjaya

Nandini

et al. 2016

Int J Pharm Pharm Sci

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Objective: Cisplatin (CIS) consumption has become a common problem that affects the health of patients around the globe. Kidney has been suspected to be particularly susceptible to the destructive effects of CIS and nephrotoxic effects are still contentious which in turn affects the Quality of Life (QoL) of patients and increase the mortality rate. This study was conducted to investigate the nephroprotective effect of Noni Juice (NJ) and Divine Noni Gold (DNG) as herbal medicine with established antioxidant properties against the controversial nephrotoxic effect of CIS in mice. Methods:Mice were divided into four groups, each group contained six mice. Group I was kept as normal, Group II received CIS (5.0 mg/kg b. wt. i. p.) on day one for 14 d. Group III and IV received NJ (0.35 ml/mouse p. o.) and DNG (0.35 ml/mouse p. o.) respectively once daily for 14 d, Group V received CIS (5.0 mg/kg b. wt. i. p.) on day one and NJ (0.35 ml/mouse p. o.) once daily for 14 d. Similarly, Group VI received CIS (5.0 mg/kg b. wt. i. p.) on day one and DNG (0.35 ml/mouse p. o.) once daily for 14 d. On day 15 blood from all the mice was collected from the carotid vein and cardiac puncture routes, and the biochemical markers viz. lactate dehydrogenase (LDH), creatinine phosphokinase (CPK), and urea were assessed. Kidney from all the animals was isolated, and catalase (CAT), glutathione (GSH), superoxide dismutase (SOD), thiols and lipid peroxidase (LPO) were estimated.Results: CIS-induced marked kidney injury; congestion of tubules, glomerular distortion foci, thickened and blocked blood vessels. Also showed significant elevation of LDH, CPK, and urea with significant inhibition of CAT, GSH, SOD, thiols activities and simultaneously elevation of LPO level. Co-administration of NJ and DNG respectively with CIS protected kidney tissues via oxidative stress inhibition.Conclusion: NJ and DNG possess protective effect against CIS-induced cellular damage in the kidney by decreasing the level of serum biochemical markers, enhancing the level of enzymatic and non-enzymatic antioxidants and maintaining the LPO level. Results suggest that NJ and DNG have strong nephroprotective effect against CIS-induced nephrotoxicity.

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An XRF study of trace elements accumulation in kidneys of tumor-bearing mice after treatment withcis-DDP with and without selenite and selenocistamine

Cited by 11 publications

References 4 publications

Azadirachta indicaAttenuates Cisplatin-Induced Nephrotoxicity and Oxidative Stress

Azadirachta indicaAttenuates Cisplatin-Induced Nephrotoxicity and Oxidative Stress

Medical applications of X-ray fluorescence for trace element research

Chemoprotective Effect of Noni (Morinda Citrifolia L.) Fruit Juice Against Cisplatin-Induced Nephrotoxicity

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