Anabolic–Androgenic Steroids and Adolescents

Denham, Bryan E.

doi:10.1097/jan.0b013e31826f4c3c

Cited by 4 publications

(1 citation statement)

References 34 publications

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“…While athletes, predominantly males, have been the primary focus of investigation among adolescent steroid users [6,19,20] relatively few national studies have assessed the prevalence of steroid use and the frequency of steroid use and its association with adverse health indicators among both male and female adolescents.…”

Section: Introductionmentioning

confidence: 99%

Steroid Use, Health Risk Behaviors and Adverse Health Indicators among U.S. High School Students

DiClemente

Jackson²,

Hertzberg³

et al. 2014

Fam Med Med Sci Res

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Adolescents' illicit use of steroids has been associated with other health risk factors, including needle sharing and HIV [13], lack of condom use [14], not wearing a seatbelt [4,14,15], carrying a weapon [8,[14][15][16], and suicide attempts [4,8,14,16] Adolescents' steroid use often co-occurs with other substance use, including injection drug use [17], alcohol, cocaine, and marijuana [18], Decreased academic performance has also been associated with steroid use [15,17].

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Section: Introductionmentioning

confidence: 99%

Steroid Use, Health Risk Behaviors and Adverse Health Indicators among U.S. High School Students

DiClemente

Jackson²,

Hertzberg³

et al. 2014

Fam Med Med Sci Res

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show abstract

Utilisation de stéroïdes anabolisants chez des adolescents ayant une activité sportive

ROCCELLA¹

2018

Neuropsychiatrie de l'Enfance et de l'Adolescence

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Nandrolone decanoate and resistance exercise affect prostate morphology and hormone receptor interface in adult rats with implications for the aging process

et al. 2019

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BackgroundNandrolone decanoate (ND) is an anabolic–androgenic steroid, and its indiscriminate use leads to subclinical alterations in the hypothalamic–pituitary–gonadal axis and androgen‐dependent organs.ObjectivesTo evaluate the effects of ND, either alone or in combination with resistance exercise (RE), on the levels of sex hormones, converting enzymes, and steroid receptors and the morphology of the ventral prostate (VP) in adult and aged rats.MethodsForty Sprague–Dawley adult and aged rats were divided into four groups each, sedentary and trained with and without ND. The groups received treatments over 8 weeks. Adult animals were sacrificed immediately following treatment completion, while the aged groups were left untreated until 300 days of age.ResultsAdult and aged animals showed reductions in testosterone levels following the different treatments, and 17β‐estradiol levels were decreased in the ND‐treated groups. The level of 5α‐reductase type 2 (5αR2) and aromatase was increased significantly in the prostates of adult animals that performed RE. However, aromatase levels were decreased in the prostates of aged animals that performed RE and were treated with ND, while 5αR2 levels were reduced in aged animals that performed RE without ND treatment. When sex receptors levels were examined, the aged and trained animals presented low androgen receptor (AR) levels. Estrogen receptors (ERs) levels were increased in the prostates of adult animals that received ND. ERβ levels were reduced after treatments in aged animals. The heights of the prostatic epithelium were reduced in all adult treated animals, coinciding with increases in PCNA and PAR4 levels.DiscussionND and RE alter the levels of hormone, converting enzymes, and sex steroid receptors and the morphology of the VP. These effects were observed in both adult and aged rats.ConclusionND, either with or without RE, during post‐puberty stage is able to interfere with the morphophysiology of the prostate.

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Anabolic–Androgenic Steroids and Adolescents

Cited by 4 publications

References 34 publications

Steroid Use, Health Risk Behaviors and Adverse Health Indicators among U.S. High School Students

Steroid Use, Health Risk Behaviors and Adverse Health Indicators among U.S. High School Students

Utilisation de stéroïdes anabolisants chez des adolescents ayant une activité sportive

Nandrolone decanoate and resistance exercise affect prostate morphology and hormone receptor interface in adult rats with implications for the aging process

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