2011
DOI: 10.1016/j.pmrj.2011.05.009
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Anabolic/Catabolic Balance in Pathogenesis of Osteoarthritis: Identifying Molecular Targets

Abstract: Osteoarthritis is the most common degenerative musculoskeletal disease. In healthy cartilage, a low turnover of extracellular matrix molecules occurs. Proper balance of anabolic and catabolic activities is thus crucial for the maintenance of cartilage tissue integrity and for the repair of molecular damages sustained during daily usage. In persons with degenerative diseases such as osteoarthritis, this balance of anabolic and catabolic activities is compromised, and the extent of tissue degradation predominate… Show more

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Cited by 171 publications
(157 citation statements)
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“…Starting from 1 month after OA induction, microCT-scan revealed multiple deposits within the joint, detached from bone, so that they could not be considered as osteophytes. These structures were composed of bone-like and cartilage-like tissues, showed catabolic and anabolic features typical of OA cartilage40 and contained CA crystals (see online supplementary figure S2). These structures resembled human synovial osteochondromatosis, a condition associated with OA,41–43 characterised by chondroid metaplasia and osteocartilaginous mineralised bodies in the capsule.…”
Section: Discussionmentioning
confidence: 99%
“…Starting from 1 month after OA induction, microCT-scan revealed multiple deposits within the joint, detached from bone, so that they could not be considered as osteophytes. These structures were composed of bone-like and cartilage-like tissues, showed catabolic and anabolic features typical of OA cartilage40 and contained CA crystals (see online supplementary figure S2). These structures resembled human synovial osteochondromatosis, a condition associated with OA,41–43 characterised by chondroid metaplasia and osteocartilaginous mineralised bodies in the capsule.…”
Section: Discussionmentioning
confidence: 99%
“…The understanding that there is an imbalance between these activities makes it necessary that therapies that promote anabolic effects and inhibit catabolic actions be adopted (Mueller and Tuan 2011). The articular biology and pathogenetic mechanisms that are involved in OA are quite similar among mammalian species.…”
Section: Biomechanical and Biochemical Aspectsmentioning
confidence: 99%
“…PTOA occurs when the equilibrium between breakdown and repair of the joint tissues becomes unbalanced 8486 . A chondral or osteochondral defect may occur after severe joint injuries such as displaced articular fractures.…”
Section: Regulation Of Adult Ac Homeostasis: the Role Of Nfat Signalingmentioning
confidence: 99%