Anabolic steroids affect human periodontal health and microbiota

Brusca, María Isabel; Verdugo, Fernando; Amighini, Celeste; Albaina, Olatz; Moragues, Marı́a D.

doi:10.1007/s00784-013-1126-9

Cited by 19 publications

(27 citation statements)

References 36 publications

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“…In previous studies, high serum testosterone levels were positively associated with increased risk for both advanced hepatic fibrosis and advanced hepatic inflammatory activity in hepatitis C virus–infected U.S. male veterans 32 . Additionally, men under anabolic androgenic abuse, and thus showing high testosterone levels, presented with more severe forms of periodontitis due to the modulation of microbiota 18 . In the current study, both high TT and CBT are associated with increased presence and severity of testosterone after adjustment for estradiol.…”

Section: Discussionmentioning

confidence: 87%

“…High testosterone, on the other hand, has been linked to severe forms of periodontitis and a high prevalence of periodontopathogenic microorganisms as well as Candida spp. in men using androgenic anabolic steroids 18 …”

mentioning

confidence: 99%

“…in men using androgenic anabolic steroids. 18 Based on the limited available data, it is plausible that variations in testosterone levels in males could be associated with the prevalence and severity of periodontitis. 19 The primary aim of this study is to test the association between serum levels of testosterone and the prevalence and severity of periodontitis in men using data from the third National Health and Nutritional Examination Survey (NHANES III).…”

mentioning

confidence: 99%

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Associations Between Sex Hormone Levels and Periodontitis in Men: Results From NHANES III

Steffens¹,

Wang²,

Starr

et al. 2015

Journal of Periodontology

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Section: Discussionmentioning

confidence: 87%

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confidence: 99%

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confidence: 99%

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Associations Between Sex Hormone Levels and Periodontitis in Men: Results From NHANES III

Steffens¹,

Wang²,

Starr

et al. 2015

Journal of Periodontology

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“…One possible explanation for these findings is that testosterone possesses immunosuppressive properties, as demonstrated by the suppressive effect on leukocyte count on orchiectomized mice and young male rats [38, 39]. Along those same lines, a recently published paper demonstrated that men using anabolic androgenic steroids present with more severe forms of periodontitis and higher prevalence of periodontopathogenic microorganisms, including some species of Candida [40]. We demonstrated that Low testosterone upregulates IL-1β production only at the site of inflammation (and not systemically), but it had no impact on IL-6 either locally or systemically.…”

Section: Discussionmentioning

confidence: 99%

Testosterone Regulates Bone Response to Inflammation

Steffens

Herrera²,

Coimbra

et al. 2014

Horm Metab Res

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This study evaluated the alveolar bone response to testosterone and the impact of Resolvin D2 (RvD2) on testosterone-induced osteoblast function. For the in vivo characterization, 60 male adult rats were used. Treatments established sub-physiologic (L), normal (N), or supra-physiologic (H) concentrations of testosterone. Forty rats were subjected to orchiectomy; 20 rats received periodical testosterone injections while 20 rats received testicular sham-operation. Four weeks after the surgeries, 10 rats in each group received a subgingival ligature around the lower first molars to induce experimental periodontal inflammation and bone loss. In parallel, osteoblasts were differentiated from neonatal mice calvariae and treated with various doses of testosterone for 48 h. Cell lysates and conditioned media were used for the determination of alkaline phosphatase, osteocalcin, RANKL, and osteoprotegerin. Micro-computed tomography linear analysis demonstrated that bone loss was significantly increased for both L and H groups compared to animals with normal levels of testosterone. Gingival IL-1β expression was increased in the L group (p < 0.05). Ten nM testosterone significantly decreased osteocalcin, RANKL, and OPG levels in osteoblasts; 100 nM significantly increased the RANKL:OPG ratio. RvD2 partially reversed the impact of 10 nM testosterone on osteocalcin, RANKL, and OPG. These findings suggest that both L and H testosterone levels increase inflammatory bone loss in male rats. While low testosterone predominantly increases the inflammatory response, high testosterone promotes a higher osteoblast-derived RANKL:OPG ratio. The proresolving mediator RvD2 ameliorates testosterone-derived downregulation of osteocalcin, RANKL, and OPG in primary murine osteoblasts suggesting a direct role of inflammation in osteoblast function.

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“…15. subjects. Among the local and/or systemic factors associated with the higher distribution of NAC species in the oral cavity, we could mention the use of prosthetic devices [11]; being elderly, [15] elderly with low body mass index [16]; being an oncological patient undergoing chemotherapy or radiotherapy [17,18]; being a diabetic patient with poor metabolic control [19], being a man using anabolic androgenic steroids [20] or a woman using oral contraceptives [21].…”

Section: Introductionmentioning

confidence: 99%

The Oral Cavity: A Reservoir that Favors Colonization and Selection of Candida parapsilosis sensu stricto Strains with High Pathogen Potential Under Conditions of Gingival-periodontal Disease

Rodríguez¹

2018

J. Dent. Sci. Ther

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The Candida parapsilosis complex comprises three genetically related species: Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis. During the last decade, Candida parapsilosis sensu stricto has become the second most commonly isolated yeast from patients with blood stream invasive fungal infections, following Candida albicans. Despite its clinical significance, little is known about its distribution and behavior in oral cavity niches. Given this background, we intended to perform a molecular characterization of 38 isolates of the Candida parapsilosis complex collected from oral cavities of immunocompetent patients with and without gingivalperiodontal disease, with the aim of determining its distribution and establishing a correlation with clinical data. Besides, we assessed the virulence of the strains by examining the in vitro biofilm-forming capacity in two different culture media: YPD and RPMI 1640. Being more frequently isolated from oral cavities with pathological conditions, 89.5% of the strains were reconfirmed to be Candida parapsilosis sensu stricto. More than 70% of the Candida parapsilosis sensu stricto strains showed biofilm-forming capacity in both culture media, reflecting a statistically significant association between biofilm-forming capacity and the clinical conditions of the subjects from whom the strains were isolated. Among the three complex species, Candida parapsilosis sensu stricto is a normal commensal in the oral cavity, being more frequently recovered in inflammatory conditions. Gingival-periodontal disease may be a factor triggering overgrowth and virulence of Candida parapsilosis sensu stricto commensal strains.

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Anabolic steroids affect human periodontal health and microbiota

Cited by 19 publications

References 36 publications

Associations Between Sex Hormone Levels and Periodontitis in Men: Results From NHANES III

Associations Between Sex Hormone Levels and Periodontitis in Men: Results From NHANES III

Testosterone Regulates Bone Response to Inflammation

The Oral Cavity: A Reservoir that Favors Colonization and Selection of Candida parapsilosis sensu stricto Strains with High Pathogen Potential Under Conditions of Gingival-periodontal Disease

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