Anacyclus Pyrethrum Extract Exerts Anticancer Activities on the Human Colorectal Cancer Cell Line (HCT) by Targeting Apoptosis, Metastasis and Cell Cycle Arrest

Mohammadi, Ali; Mansoori, Behzad; Baradaran, Pooneh Chokhachi; Baradaran, Sepideh Chokhachi; Baradaran, Behzad

doi:10.1007/s12029-016-9884-7

Cited by 21 publications

(14 citation statements)

References 29 publications

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“…As reported in earlier data, the roots of A. pyrethrum (L.). possess interesting pharmacological properties including anticancer [ 11 ], aphrodisiac [ 12 , 13 , 14 ], anti-convulsive [ 15 ], androgenic and fertilizing [ 12 , 16 ], antiparasitic and antibiotic [ 17 ], bio-insecticide [ 18 ], anti-amnesic [ 19 ], antidiabetic [ 20 , 21 ], antifungal, and immunostimulant effects [ 16 , 22 ]. In addition, this plant is prescribed for treating partial paralysis of the tongue and lips [ 23 ], gout, and sciatica [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Anacyclus pyrethrum var. pyrethrum (L.) and Anacyclus pyrethrum var. depressus (Ball) Maire: Correlation between Total Phenolic and Flavonoid Contents with Antioxidant and Antimicrobial Activities of Chemically Characterized Extracts

Jawhari

Moussaoui

Bourhia

et al. 2021

Plants

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In this work, two varieties of Anacyclus pyrethrum (L.) including Anacyclus pyrethrum var. pyrethrum (L.) and Anacyclus pyrethrum var. depressus (Ball) Maire were evaluated for their mineral and chemical compositions, total phenolic and flavonoid contents, and antimicrobial and antioxidant activities using hydroalcoholic extracts from their different parts (leaves, capitula, roots, and seeds). The phytochemical and mineral compositions were carried out using standard methods. The antioxidant activity was determined using the DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2-azino-bis 3-ethylbenzothiazolin-6-sulfonic acid), and FRAP (ferric reducing antioxidant power) tests. The antimicrobial activity was assayed using the agar diffusion, minimum inhibitory concentration, and minimum bactericidal concentration methods. The results of the chemical analysis showed that both varieties contained interesting mineral and chemical compositions with potentially active compounds; among them, N-isobutyl-2,4-heptadiene-6-monoynamide and cinnamic acid were detected in the Anacyclus pyrethrum var. pyrethrum (L.) only while thiadiazolo [5,4-d] pyrimidin-7-amine and N-isobutyl-2,4-undecadiene-8,10-diynamide compounds were limited to the Anacyclus pyrethrum var. depressus (Ball) Maire. In vitro antioxidant and antimicrobial activities of the two varieties demonstrated that the different parts had prominent antioxidant and antimicrobial properties. The principal component analysis (PCA) showed great similarity in the activity of the leaves, capitula, and seeds of both plants and a high difference in roots. Anacyclus pyrethrum var. pyrethrum roots were characterized by a high content in phenols and flavonoids and better antibacterial activities compared to Anacyclus pyrethrum var. depressus (Ball) Maire roots, which were characterized by better antioxidant activities. From this study, it can be concluded that the two varieties of Anacyclus pyrethrum (L.) showed promising mineral and chemical compositions with antioxidant and antimicrobial properties.

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Section: Introductionmentioning

confidence: 99%

Anacyclus pyrethrum var. pyrethrum (L.) and Anacyclus pyrethrum var. depressus (Ball) Maire: Correlation between Total Phenolic and Flavonoid Contents with Antioxidant and Antimicrobial Activities of Chemically Characterized Extracts

Jawhari

Moussaoui

Bourhia

et al. 2021

Plants

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“…Herbal medicine plants, herbal extracts and natural products have been used for treating a wide range of human ailments since ancient times (71). Since about half of current medicines and drugs are derived from different types of plants, it is clear that natural products should be further investigated as potentially effective agents in cancer therapy (72)(73)(74)(75)(76)(77)(78).…”

Section: Herbal Extracts As Natural Pss In Pdtmentioning

confidence: 99%

Photodynamic therapy for cancer: Role of natural products

Mansoori¹,

Mohammadi

Doustvandi

et al. 2019

Photodiagnosis and Photodynamic Therapy

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161

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Photodynamic therapy (PDT) is a relatively new and promising modality for the treatment of cancer. PDT involves administering a photosensitizing dye, i.e. photosensitizer, that selectively accumulates in tumors, and shining a light source on the lesion with a wavelength matching the absorption spectrum of the photosensitizer, that exerts a cytotoxic effect after excitation. The reactive oxygen species produced during PDT are responsible for the oxidation of biomolecules, which in turn cause cell death and the necrosis of malignant tissue. PDT is a multi-factorial process that generally involves apoptotic death of the tumor cells, degeneration of the tumor vasculature, stimulation of anti-tumor immune response, and induction of inflammatory reactions in the illuminated lesion. Numerous compounds with photosensitizing activity have been introduced commercially. Although many papers have been published with regard to PDT in the last decade, there has been relatively little focus on natural medicinal plant extracts and compounds derived therefrom. Herbal plants and their extracts are natural substances, and in comparison with synthetic chemicals are considered "green". This review focuses on the different mechanisms of PDT and discusses the role of various plant extracts and natural compounds either alone or in combination for carrying out PDT on different types of cancers.

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“…The results indicate that Anacyclus pyrethrum extract can successfully induce apoptosis in HCT cells. 37 A study was investigated as cytotoxic and apoptotic effect of Anacyclus pyrethrum plants extract in KB cancer cell lines. Hepato-protective activity: A study designed to evaluate the hepato-protective effect of "extract of Anacyclus pyrethrum Linn" (APE) against anti-tubercular drug-induced hepatotoxicity in V groups of rats (for 28 days).…”

Section: 15mentioning

confidence: 99%

Aqarqarha (Anacyclus Pyrethrum Dc.) a Potent Drug in Unani Medicine: A Review on Its Historical and Phyto-Pharmacological Perspective

Tauheed¹,

Hamiduddin²,

Ali³

2017

J. Pharm. Sci. Innov.

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Aqarqarha (Anacyclus pyrethrum DC.) is a very famous botanical origin drug in Unani system of medicine. It is used since antiquity. It is described by Dioscorides, Galen, Avicena, Avenzoar, Ishaque bin Imran. According to Galen use of this drug is beneficial in chronic Paralysis, Khadar (numbness), toothache, intermittent fever. Rhazes and other Unani physician used it for strengthening the teeth, easy extraction of the teeth, paralysis, facial palsy, epilepsy, colitis, muqawwi-i-bah (aphrodisiac), mharrik-ibah (sexual stimulant), and qate balgham (phelemenogogue). Usually the root of a plant is used as medicine; flowers and leaves are also used in Unani system of medicine. Various activities were evaluated like Spermatogenic, Anti-diabetic, Immunostimulating, Antidepressant, Anti-convulsant, Memory-enhancing and Anticancer Activity. It is used in various oral (Majoone, Tiryaqi, Jawarish) and local formulation (Roghan / oil, Tila / liniment, Sunoon / dentifrices, Qairooti / paste). These all findings reveal immense utility of Aqararha in Unani system of medicine and scope for developing as a potent therapeutic tool.

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Anacyclus Pyrethrum Extract Exerts Anticancer Activities on the Human Colorectal Cancer Cell Line (HCT) by Targeting Apoptosis, Metastasis and Cell Cycle Arrest

Abstract: These results indicate that Anacyclus pyrethrum extract can successfully induce apoptosis in HCT cells. Therefore, it could be used as a novel therapeutic candidate for colorectal cancer treatment.

Cited by 21 publications

References 29 publications

Anacyclus pyrethrum var. pyrethrum (L.) and Anacyclus pyrethrum var. depressus (Ball) Maire: Correlation between Total Phenolic and Flavonoid Contents with Antioxidant and Antimicrobial Activities of Chemically Characterized Extracts

Anacyclus pyrethrum var. pyrethrum (L.) and Anacyclus pyrethrum var. depressus (Ball) Maire: Correlation between Total Phenolic and Flavonoid Contents with Antioxidant and Antimicrobial Activities of Chemically Characterized Extracts

Photodynamic therapy for cancer: Role of natural products

Aqarqarha (Anacyclus Pyrethrum Dc.) a Potent Drug in Unani Medicine: A Review on Its Historical and Phyto-Pharmacological Perspective

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