Anaemia and its association with month and blood phenotype in blood donors in Fako division, Cameroon

Kwenti, Tebit Emmanuel; Kwenti, Tayong Dizzle Bita

doi:10.1186/s12878-016-0070-8

Cited by 10 publications

(14 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, the increased risk of LHD in females compared with males was significantly higher in studies from Africa (OR 5. 24…”

Section: Sexmentioning

confidence: 99%

“…LHD by age (years) was reported in 19 new studies [9,10,12,15,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. In 14 studies which reported results separate for men and women, the general trend across studies for men was for LHD rates to increase with age (Figure 4), whereas for women there were fewer deferrals among women over 50 compared to women younger than 50.…”

Section: Agementioning

confidence: 99%

“…One study from Africa [24] reported deferral rates by age for men and women separately but these were universally very high, with the lowest rate of LHD in any one age group being 27% (in men in their 30s) and the highest 71.4% (in women under 20). Two European studies found that male donors who were deferred for low Hb had a higher mean age (years) than those not deferred, (47 vs 43) [19] (50 vs 46) [20].…”

Section: Agementioning

confidence: 99%

See 2 more Smart Citations

Donor Deferral Due to Low Hemoglobin—An Updated Systematic Review

Browne

Fisher

Masconi

et al. 2020

Transfusion Medicine Reviews

View full text Add to dashboard Cite

Background/Objectives: Blood donors attending a donation session may be deferred from donating blood due to a failure to meet low hemoglobin (Hb) thresholds. This costs the blood donor service, and donors, valuable time and resources. In addition, donors who are deferred may have more symptoms and as a direct and/or indirect effect of their experience return rates of donors deferred for low Hb are reduced, even in repeat donors. It is therefore vital that low Hb deferral (LHD) is minimized. The aim of this updated systematic review is to expand the evidence base for factors which affect a donor's risk of deferral due to low Hb. Materials/Methods: Studies were identified by searching MEDLINE, Embase, The Cochrane Library and the WHO International Clinical Trials Registry to March 2019. Demographic data, donor history, hematological/biological factors and the primary outcome of deferral due to low Hb were extracted. Our primary outcome was deferral due to low Hb. Analyses were descriptive and quantitative; pooled odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by meta-analysis using random effects models. Results: A total of 116 studies met the inclusion criteria. Meta-analysis showed a significantly greater risk of LHD in females compared with males in studies applying universal Hb thresholds for males and females (OR 14.62 95%CI 12.43-17.19) and in those which used sex-specific thresholds (OR 5.73, 95%CI 4.36-7.53). Higher rates of LHD were also associated with increasing age in men, low body weight, shorter inter-donation interval, donors of Hispanic or African descent, higher ambient temperature, donors with low ferritin levels and donation in a fixed donor center. There was conflicting evidence on the effect of new and repeat donor status, and blood group. Conclusion: This work has strengthened the evidence of the previous review in identifying factors that should be considered in studies of donor deferral and highlighting areas in need of further study, including ABO and Rh blood groups, previous platelet donation, diet, smoking, time of day, and genetic data. These factors may lead to individually tailored donation criteria for safe and efficient donation in the future.

show abstract

“…For example, the increased risk of LHD in females compared with males was significantly higher in studies from Africa (OR 5. 24…”

Section: Sexmentioning

confidence: 99%

Section: Agementioning

confidence: 99%

Section: Agementioning

confidence: 99%

See 1 more Smart Citation

Donor Deferral Due to Low Hemoglobin—An Updated Systematic Review

Browne

Fisher

Masconi

et al. 2020

Transfusion Medicine Reviews

View full text Add to dashboard Cite

show abstract

“… 12 Anemia is a common manifestation in SSA, especially in children and pregnant women, and malaria is one of its major causes. 52 HIV, on the other hand, infects and depletes CD4 + T cells, thereby exposing infected patients to opportunistic infections. HIV is also associated with dysregulation of proinflammatory cytokines and chemokines in plasma and lymph nodes, thereby influencing disease progression.…”

Section: Impact Of Mhc In Ssamentioning

confidence: 99%

Malaria and HIV coinfection in sub-Saharan Africa: prevalence, impact, and treatment strategies

Kwenti¹

2018

RRTM

Self Cite

View full text Add to dashboard Cite

Malaria and HIV, two of the world’s most deadly diseases, are widespread, but their distribution overlaps greatly in sub-Saharan Africa. Consequently, malaria and HIV coinfection (MHC) is common in the region. In this paper, pertinent publications on the prevalence, impact, and treatment strategies of MHC obtained by searching major electronic databases (PubMed, PubMed Central, Google Scholar, ScienceDirect, and Scopus) were reviewed, and it was found that the prevalence of MHC in SSA was 0.7%–47.5% overall. Prevalence was 0.7%–47.5% in nonpregnant adults, 1.2%–27.8% in children, and 0.94%–37% in pregnant women. MHC was associated with an increased frequency of clinical parasitemia and severe malaria, increased parasite and viral load, and impaired immunity to malaria in nonpregnant adults, children, and pregnant women, increased in placental malaria and related outcomes in pregnant women, and impaired antimalarial drug efficacy in nonpregnant adults and pregnant women. Although a few cases of adverse events have been reported in coinfected patients receiving antimalarial and antiretroviral drugs concurrently, available data are very limited and have not prompted major revision in treatment guidelines for both diseases. Artemisinin-based combination therapy and cotrimoxazole are currently the recommended drugs for treatment and prevention of malaria in HIV-infected children and adults. However, concurrent administration of cotrimoxazole and sulfadoxine–pyrimethamine in HIV-infected pregnant women is not recommended, because of high risk of sulfonamide toxicity. Further research is needed to enhance our understanding of the impact of malaria on HIV, drug–drug interactions in patients receiving antimalarials and antiretroviral drugs concomitantly, and the development of newer, safer, and more cost-effective drugs and vaccines to prevent malaria in HIV-infected pregnant women.

show abstract

“…The issue of young age of donors and health, as well as adverse effect of donation, was little studied in LMICs (Bahadur et al ., ). Anaemia (<13 g dL −1 for male and <12 g dL −1 for females) is the most common cause of donor deferral, particularly in women (30% in Cameroon, Kwenti & Kwenti, ; 27% in Libya, Abud et al, ) and was more frequent in females. However, there was no evidence that the current eligibility criteria (12·5 g dL −1 ± 0·5 and 50 kg) increased the number of adverse post‐donation events.…”

Section: Resultsmentioning

confidence: 99%

Current approaches to increase blood donations in resource‐limited countries

2019

Transfusion Medicine

View full text Add to dashboard Cite

SUMMARY Background Low‐ and middle‐income countries (LMIC) suffer from chronic or seasonal blood shortage. The first review was published in 2007. Methods The review of literature since 2005 presented here uncovered a fairly large number of articles justifying the grouping of blood donation issues into five geographical areas sharing common background. These are Sub‐Saharan Africa (SSA), Muslim countries, India, China/South East Asia and Latin America/Caribbean islands (LA&C). Results SSA countries start collecting at 16–18 years of age in schools where female donors can be reached better than in other settings. Community‐oriented culture favours family donors who need, similar to volunteer non‐remunerated donors (VNRD), to be actively induced to repeat donation. Muslim countries share the contradiction of religion encouraging blood donation but restrain women from donating. The active involvement of religious leaders and the progressive easing of female participation are the keys to increasing blood donation. In India, ‘social duty’ is a major inducement to blood donation but also benefits and rewards. Ways of involving female donors by reducing the donation age to 16 years and providing donor education in schools need to be considered. In China and East Asia, the option of small‐volume donation impairs blood collection without being justified by scientific evidence but is a concession to culture. Reducing the donation age would also help the supply. In LA&C, the concept of ‘social capital’ was developed as a complement or alternative to the theory of planned behaviour. Conclusions Strategies to improve blood donation and repeat donation should be innovative and adapted to local or regional culture and environment.

show abstract

Anaemia and its association with month and blood phenotype in blood donors in Fako division, Cameroon

Cited by 10 publications

References 15 publications

Donor Deferral Due to Low Hemoglobin—An Updated Systematic Review

Donor Deferral Due to Low Hemoglobin—An Updated Systematic Review

Malaria and HIV coinfection in sub-Saharan Africa: prevalence, impact, and treatment strategies

Current approaches to increase blood donations in resource‐limited countries

Contact Info

Product

Resources

About