1970
DOI: 10.1111/imj.1970.19.1.34
|View full text |Cite
|
Sign up to set email alerts
|

Anaemia and Temporary Erythroblastopaenia in Children

Abstract: Summary Over a period of 7 years, 12 patients were seen at the Royal Alexandra Hospital for Children with a symptomatic normocytic, normochromic anaemia and reticulocytopaenia. The initial bone marrow aspirates revealed erythroblastopaenia as the only abnormality. The cause of this condition remains uncertain. However, all children fully recovered within a few weeks after diagnosis. A single course of steroid therapy was given to 3 children, whilst the remainder received no therapy. Recurrence was observed in … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

0
9
0

Year Published

1975
1975
2014
2014

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 15 publications
(9 citation statements)
references
References 8 publications
0
9
0
Order By: Relevance
“…IgG inhibitors in sera against erythroid colony growth in vitro [24] against erythropoie tin [25] and IgG cytotoxic for erythroblasts [10] have been described. It is not surprising, therefore, that antithymo cyte globulin, immunosuppressive cytotoxic drugs, and corticosteroids have been employed both in TEC and PRCA [6,9,10,22,[24][25][26], Treatment may be of little or no benefit in TEC, since recovery usually occurs promptly [26]. However, recovery may be delayed for up to several months [22], In PRCA, however, the course is generally protracted, although a re sponse to corticosteroids and/or immunosuppressive drugs may occur [2,9].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…IgG inhibitors in sera against erythroid colony growth in vitro [24] against erythropoie tin [25] and IgG cytotoxic for erythroblasts [10] have been described. It is not surprising, therefore, that antithymo cyte globulin, immunosuppressive cytotoxic drugs, and corticosteroids have been employed both in TEC and PRCA [6,9,10,22,[24][25][26], Treatment may be of little or no benefit in TEC, since recovery usually occurs promptly [26]. However, recovery may be delayed for up to several months [22], In PRCA, however, the course is generally protracted, although a re sponse to corticosteroids and/or immunosuppressive drugs may occur [2,9].…”
Section: Discussionmentioning
confidence: 99%
“…These include the red cell aplasia related to drug or chemical exposure, viral hepatitis, pregnancy, malnutrition or thymoma [1,2]. Other causes are congenital pure red cell aplasia [3] (Dia mond Blackfan syndrome), the acute erythroblastopenia of Gasser [4] transient erythroblastopenia of childhood (TEC) [5,6] and the parvovirus-induced aplastic crisis as sociated with hemolytic anemia [7],…”
Section: Introductionmentioning
confidence: 99%
“…One of these fathers (B) was classified as having irondeficiency anaemia. This occurred prior to 1970, when TEC was first described (7,8), and we reexamined his records without finding convincing evidence of TEC. At 3 y of age he was treated with iron, because of anaemia with a B-Hb value ''less than 60%'' (Ͻ95 g/l).…”
Section: Discussionmentioning
confidence: 98%
“…This disease was first described as a distinct entity by Wranne (7), who also participated in the present project until he unexpectedly passed away in 1995. TEC was also independently described during the same year by Lovric (8) and later summarized by Glader (9). The pathogenic process most probably commences 2-3 months before clinical diagnosis is achieved, possibly initiated by an immune attack on early erythroid progenitors (10)(11)(12).…”
mentioning
confidence: 97%
“…Distinguishing between DBA and TEC, especially in the first year of life, can be challenging (1)(2)(3). TEC was first described by Wranne in 1970 (4) and more or less simultaneously by Lovric (5). The pathophysiologic mechanism of TEC seems to be heterogeneous.…”
Section: Introductionmentioning
confidence: 99%