Anaemia, folate and vitamin B12 deficiency among pregnant women in an area of unstable malaria transmission in eastern Sudan

Abdelrahim, Ishraga I.; Adam, Gamal K.; Mohmmed, Ahmed A; Salih, Magdi M; Ali, Nagi I.; Elbashier, Mustafa I.; Adam, Ishag

doi:10.1016/j.trstmh.2008.10.007

Cited by 26 publications

(33 citation statements)

References 15 publications

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“…The prevalence of anaemia in this study was lower than the prevalence (70-80%) that we recently reported among pregnant women and among adolescent girls (96.8%) of eastern Sudan [3,14,15]. The lower prevalence of anaemia in the current study could be explained by the differences in the seasons during which the surveys were conducted.…”

Section: Discussioncontrasting

confidence: 90%

Anaemia, Zinc and Copper Deficiencies Among Pregnant Women in Central Sudan

Bushra

Elhassan

Ali³

et al. 2009

Biol Trace Elem Res

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Anaemia is a widespread problem in many parts of the world especially in tropic areas. Among pregnant women, it has negative consequences on maternal and perinatal outcomes. A cross-sectional study was conducted to investigate the prevalence of anaemia, iron, zinc and copper deficiencies among pregnant women in Wad Medani hospital, central Sudan and to examine the relationship of these micronutrients with haemoglobin (Hb) levels. One hundred four (52.5%) out of 200 pregnant women had anaemia (Hb < 11 gm/dl) and 3 (1.5) % had severe anaemia (Hb < 7 gm/dl). Iron deficiency (S-ferritin < 15 µg/l), iron deficiency anaemia (<11 gm/dl and S-ferritin < 15 µg/l) were prevalent in 25 (12.5%) and 13 (6.5%) of these women, respectively. Ninety (45.0%) and eight (4.0%) of these women had zinc (<80 µg/ml) and copper (<80 µg/ml) deficiency, respectively. In 24 (12.0%) of these women, there were ≥2 deficiencies of these elements. S-copper was not [corrected] significantly lower in patients with anaemia. While age, parity, gestational age, ferritin, zinc and copper were not predictors for anaemia, women who practiced pica were at higher risk for anaemia (OR = 3.4, 95% CI = 1.4-7.9, P = 0.004). Gestational age was significantly inversely correlated with haemoglobin (r = 0.161, P = 0.03), S-ferritin (r = 0.285, P = 0.001) and S-zinc (r = 0.166, P = 0.02). Thus, dietary and supplement interventions are required to prevent and control anaemia in this setting. Further research is needed.

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Section: Discussioncontrasting

confidence: 90%

Anaemia, Zinc and Copper Deficiencies Among Pregnant Women in Central Sudan

Bushra

Elhassan

Ali³

et al. 2009

Biol Trace Elem Res

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“…An additional striking finding was the pooled insufficiency rate of 65% (I 2 = 95%) ( Figure 4) (28,52,65,77,93) from the 5 studies in the Eastern Mediterranean region. On the contrary, insufficiency rates of ,8% were found in 2 studies conducted in Thailand and Sudan, where the authors attributed the low rates of insufficiency to the consumption of fish and animal/fermented products, respectively (although details of dietary intake were not provided) (49,50).…”

Section: Prevalence Of Vitamin B-12 Insufficiency In Pregnancymentioning

confidence: 99%

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis

Sukumar

Rafnsson

Kandala

et al. 2016

The American Journal of Clinical Nutrition

107

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Background: Vitamin B-12 and folate are micronutrients essential for normal embryogenesis. Vitamin B-12 insufficiency in pregnancy is high in certain parts of the world, such as India, and although this has been linked to low birth weight (LBW) in these populations, the relation between vitamin B-12 and birth weight (BW) elsewhere is unknown. Objectives: We performed a systematic review to assess 1) the worldwide prevalence of vitamin B-12 insufficiency in pregnancy and 2) its association with BW. Design: A search of 5 electronic databases was performed to identify eligible articles. Random-effects meta-analysis was conducted according to geographic regions and pregnancy trimesters for the prevalence subreview and by categorical measures of BW. Results: A total of 57 and 23 articles were included for the prevalence and BW subreviews, respectively. The pooled estimates of vitamin B-12 insufficiency were 21%, 19%, and 29% in the first, second, and third trimesters, respectively, with high rates for the Indian subcontinent and the Eastern Mediterranean. The large heterogeneity between studies was partially addressed by creating a standardized score for each study (mean vitamin B-12 insufficiency O cutoff value), which internally corrected for geographic region, trimester, and assay type. Twelve of the 13 longitudinal studies included showed a decrease in mean or median vitamin B-12 across trimesters. Pooled analysis showed nonsignificantly lower maternal vitamin B-12 concentrations in LBW than in normal-BW infants and higher odds of LBW with lower vitamin B-12 values (adjusted OR: 1.70; 95% CI: 1.16, 2.50), but studies from India largely contributed to the latter. Conclusions: Our review indicates that vitamin B-12 insufficiency during pregnancy is common even in nonvegetarian populations and that concentrations of vitamin B-12 decrease from the first to the third trimester. There is no consistent association between vitamin B-12 insufficiency and LBW. However, given the long-term risks of LBW, this observation warrants further cohort studies and randomized controlled trials.Am J Clin Nutr 2016;103:1232-51.

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“…The prevalence of anemia in lactating and pregnant women was 43% (95% CI, 41%-45%) and 84% of anemia was iron deficiency anemia followed by normocytic normocromic anemia This finding is lower when compared to findings from eastern Ethiopia [48] Germany [32], Nepal [33], India [35], eastern Sudan [40], Kenya [41]; agrees with findings from Ghana [39]and higher than finding from northern Ethiopia [49] southern Ethiopia [45] Trinidad and Tobago [34], Benin [42]. These might be due to the reason that different distribution of determinants of anemia across different social, cultural or geographical areas.…”

Section: Discussionmentioning

confidence: 97%

Pregnant mothers are more anemic than lactating mothers, a comparative cross-sectional study, Bahir Dar, Ethiopia

Feleke

Feleke²

2018

BMC Hematol

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BackgroundInformation on the hemoglobin status of pregnant and lactating mothers was scarce. The objectives of this study were to determine the burden and determinants of anemia in the pregnant and lactating mother.MethodsA comparative cross-sectional study was conducted. Descriptive statistics were used to identify the prevalence of anemia. Binary logistic regression and multiple linear regressions were used to identify the predictors of anemia.ResultsThe prevalence of anemia in lactating and pregnant women was 43.00% (95% CI {confidence interval}, 41% - 45%) and 84% of anemia was microcytic and hypocromic anemia. Anemia in lactating and pregnant women was positively associated with malaria infection [AOR{adjusted odds ratio} 3.61 (95% CI: 2.63–4.95)], abortion [AOR 6.63 (95% CI: 3.23–13.6)], hookworm infection [AOR 3.37 (95% CI: 2.33–4.88)], tea consumption [AOR 3.63 (95% CI: 2.56–5.14)], pregnancy [AOR 2.24 (95% CI: 1.57–3.12)], and Mid-upper arm circumference [B 0.36 (95% CI: 0.33, −0.4)]. Anemia in pregnant and lactating mother was negatively associated with urban residence [AOR 0.68, (95% CI: 0.5–0.94)], iron supplementation during pregnancy [AOR 0.03 (95% CI, 0.02–0.04)], parity [B -0.18 (95% CI: -0.23, −0.14)], age [B -0.03 (95% CI: -0.04, −0.03)].ConclusionThe burden of anemia was higher in pregnant women than lactating women.

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Anaemia, folate and vitamin B12 deficiency among pregnant women in an area of unstable malaria transmission in eastern Sudan

Cited by 26 publications

References 15 publications

Anaemia, Zinc and Copper Deficiencies Among Pregnant Women in Central Sudan

Anaemia, Zinc and Copper Deficiencies Among Pregnant Women in Central Sudan

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis

Pregnant mothers are more anemic than lactating mothers, a comparative cross-sectional study, Bahir Dar, Ethiopia

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