Anaemia in Dermatitis Herpetiformis: Prevalence and Associated Factors at Diagnosis and One-year Follow-up

Alakoski, Anna; Pasternack, Camilla; Reunala, Timo; Kaukinen, Katri; Huhtala, Heini; Mansikka, Eriika; Jernman, Juha; Hervonen, Kaisa; Salmi, Teea

doi:10.2340/00015555-3795

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…There have been only a few studies addressing the differences between males and females affected by DH, and the main focus has been on newly diagnosed patients. Previous studies have linked male sex with younger age at the onset of DH symptoms, more severe skin symptoms at diagnosis and more frequent initiation of dapsone after diagnosis ( 28 – 30 ). Furthermore, 2 studies have shown an increased risk for delayed diagnosis in females ( 21 , 29 ), but, in contrast, 1 study associated increased diagnostic delay with male sex ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

Sex-differences in Gluten-free Dietary Adherence and Clinical Symptoms in Patients with Long-term Treated Dermatitis Herpetiformis

Pasternack

Hervonen²,

Mansikka³

et al. 2022

Acta Derm Venereol

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Dermatitis herpetiformis is a blistering autoimmune skin disease, and a cutaneous manifestation of coeliac disease. The burden of coeliac disease is increased especially in females, but studies concerning sex differences in patients with long-term treated dermatitis herpetiformis are scarce. This questionnaire study compared adherence to a gluten-free diet, clinical symptoms and well-being between females and males in a cohort of 237 long-term treated (median 24 years) patients with dermatitis herpetiformis. Females had better adherence to a gluten-free diet (p = 0.022) and they used dapsone significantly less often at the time of the study than did males (4% vs 13%, p = 0.017). The occurrence of skin symptoms was equal in both sexes, but dermatological quality of life was lower in females (p = 0.024), and gastrointestinal symptoms were more severe among females with dermatitis herpetiformis than among males (p = 0.027). In conclusion, long-term treated female patients with dermatitis herpetiformis have better adherence to a gluten-free diet, but they also experience more severe clinical symptoms compared with males.

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Section: Discussionmentioning

confidence: 99%

Sex-differences in Gluten-free Dietary Adherence and Clinical Symptoms in Patients with Long-term Treated Dermatitis Herpetiformis

Pasternack

Hervonen²,

Mansikka³

et al. 2022

Acta Derm Venereol

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“…Hämolytische Anämie tritt bei allen Personen bis zu einem gewissen Grad auf. Eine Studie aus dem Jahr 2021, die die Prävalenz von Anämie bei DH untersuchte, ergab, dass die Anämie bei DH zwar relativ gering ist, aber häufiger auftritt, wenn der Patient Dapson verwendet [72]. Methämoglobinämie tritt auf, wenn rote Blutkörperchen Methämoglobin in Konzentrationen von mehr als 1% enthalten.…”

Section: Managementunclassified

Dermatitis Herpetiformis: Ein aktualisierter Überblick zu Diagnose, Krankheitsüberwachung und Management

Nguyen

Kim

2022

Kompass Autoimmun

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Dermatitis herpetiformis (DH), Morbus Duhring, wird durch Glutensensitivität verursacht und betrifft 11,2 bis 75,3 pro 100 000 Menschen in den Vereinigten Staaten und Europa mit einer Inzidenz von 0,4 bis 3,5 pro 100 000 Menschen pro Jahr. DH zeichnet sich durch einen symmetrischen Blasenausschlag auf den Streckflächen mit starkem Juckreiz aus. Die Diagnose wird weiterhin primär durch pathognomonische Befunde der Histopathologie, insbesondere der direkten Immunfluoreszenz (DIF), gestellt. In jüngster Zeit haben sich Antikörper gegen epidermale Transglutaminase (TG3) als primäre diagnostische Serologie erwiesen, während Anti-Gewebstransglutaminase (TG2) und andere Autoantikörper zur Unterstützung der Diagnose und zur Krankheitsüberwachung verwendet werden können. Neu diagnostizierte Patienten mit DH sollten auf Begleiterkrankungen und Komplikationen untersucht und beurteilt werden. Eine glutenfreie Diät (GFD) und Dapson sind nach wie vor die Hauptpfeiler der Behandlung, aber bei hartnäckigen Fällen können andere Medikamente erforderlich sein. Gut kontrollierte DH-Patienten, die von einem Dermatologen, einem Gastroenterologen und einem Ernährungsberater betreut werden, haben eine hervorragende Prognose. Unsere Übersichtsarbeit beschreibt umfassend die aktuellen diagnostischen Methoden sowie Methoden zur Überwachung des Krankheitsverlaufs. Wir beschreiben zudem sowohl die traditionellen als auch die neuartigen Optionen für die Krankheitsbehandlung, die in der Literatur beschrieben werden.

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Dermatitis Herpetiformis: An Update on Diagnosis, Disease Monitoring, and Management

Nguyen

Kim

2021

Medicina

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Dermatitis herpetiformis (DH), Duhring disease, is caused by gluten sensitivity and affects 11.2 to 75.3 per 100,000 people in the United States and Europe with an incidence of 0.4 to 3.5 per 100,000 people per year. DH is characterized by a symmetrical blistering rash on the extensor surfaces with severe pruritus. The diagnosis continues to be made primarily by pathognomonic findings on histopathology, especially direct immunofluorescence (DIF). Recently, anti-epidermal transglutaminase (TG3) antibodies have shown to be a primary diagnostic serology, while anti-tissue transglutaminase (TG2) and other autoantibodies may be used to support the diagnosis and for disease monitoring. Newly diagnosed patients with DH should be screened and assessed for associated diseases and complications. A gluten-free diet (GFD) and dapsone are still mainstays of treatment, but other medications may be necessary for recalcitrant cases. Well-controlled DH patients, managed by a dermatologist, a gastroenterologist, and a dietician, have an excellent prognosis. Our review comprehensively details the current diagnostic methods, as well as methods used to monitor its disease course. We also describe both the traditional and novel management options reported in the literature.

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Anaemia in Dermatitis Herpetiformis: Prevalence and Associated Factors at Diagnosis and One-year Follow-up

Cited by 3 publications

References 37 publications

Sex-differences in Gluten-free Dietary Adherence and Clinical Symptoms in Patients with Long-term Treated Dermatitis Herpetiformis

Sex-differences in Gluten-free Dietary Adherence and Clinical Symptoms in Patients with Long-term Treated Dermatitis Herpetiformis

Dermatitis Herpetiformis: Ein aktualisierter Überblick zu Diagnose, Krankheitsüberwachung und Management

Dermatitis Herpetiformis: An Update on Diagnosis, Disease Monitoring, and Management

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