Anaemia in systemic lupus erythematosus: from pathophysiology to clinical assessment

Giannouli, Stavroula

doi:10.1136/ard.2005.041673

Cited by 162 publications

(127 citation statements)

References 66 publications

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“…Thus, it is no surprise that the majority of SLE patients had anemia due to chronic disease. 5,8 Moreover, renal disorders were found in more than half of the subjects (59 %), in the long run wouldl aid in the precipitation of anemia. The anemia manifests as the kidney's ability to produce erythropoietin, a hormone crucial for red blood cell formation, is severely hampered.…”

Section: Discussionmentioning

confidence: 99%

“…11 Also, SLE patients were in productive age with their average age was 28-43 years. 8,11 More than fifty percent of the subjects had been diagnosed with SLE for 1-5 years and more than thirty percent for 5-10 years. Thus, it is no surprise that the majority of SLE patients had anemia due to chronic disease.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 The most common causes of anemia in SLE are anemia in chronic disease (ACD), irondeficiency anemia (IDA), and autoimmune hemolytic anemia (AIHA), while drug-induced anemia and renal failure anemia are not uncommon. 8 …”

Section: Introductionmentioning

confidence: 99%

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Two Years Profile of Anemia in Systemic Lupus Erythematosus Patients at West Java’s Top Referral Hospital, Indonesia

Usman¹,

Hamijoyo²,

Tjandrawati³

2017

amj

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Background: Anemia is a common clinical manifestation in Systemic Lupus Erythematosus (SLE) patients. Anemia can be caused by an ineffective hematopoietic process or excessive red blood cell destruction. The aim of this study was to classify and characterize anemia in SLE patients. Methods: This study involved 97 outpatients visiting the Rheumatology Clinic of Dr. Hasan Sadikin General Hospital Bandung, from January 2013 to September 2014. Patient data was collected from medical records and study subjects were selected according to the American College of Rheumatology 1997 criteria for SLE, and the characteristic of anemia among outpatients were described according to the World Health Organization criteria. Results: The characteristics among 97 respondents showed 95 (98%) were female; 32 (33%) were 21-30 years old; and 49 (51%) had SLE for 1-5 years. The characteristics and classification of anemia, 57 (59%) had normocytic normochromic, and 33 (34%) had microcytic hypochromic anemia. According to the severity classification, 48 (50 %) had moderate anemia, only 8 (8%) had severe anemia. Four (4%) subjects had anemic conjunctiva, 45 (46%) had fatigue and 48 (50%) had no clinical manifestations of anemic conjunctiva and fatigue. Conclusions: Moderate anemia, normocytic normochromic anemia are the most prevalent among the subjects. Half of the anemic SLE patient has no clinical manifestation of anemic conjunctiva and fatigue.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Two Years Profile of Anemia in Systemic Lupus Erythematosus Patients at West Java’s Top Referral Hospital, Indonesia

Usman¹,

Hamijoyo²,

Tjandrawati³

2017

amj

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“…15 Our previous data have indicated that allogeneic MSCT was a feasible and safe therapy in patients with refractory SLE 8,9 and drug-resistant polymyositis and dermatomyositis. 16 Thirty-five SLE patients with refractory cytopenia were enrolled in this study. One and three months after the combined MSCT and immunosuppressive agent treatment, 20 patients with leukopenia and 24 patients with thrombocytopenia showed hematological improvement.…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal SCT ameliorates refractory cytopenia in patients with systemic lupus erythematosus

Wang

Liang

et al. 2012

Bone Marrow Transplant

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Our previous data have revealed that proteinuria, antinuclear antibodies and anti-dsDNA antibodies in refractory systemic lupus erythematosus (SLE) reduced after MSC infusion. This study focused on the roles of mesenchymal SCT (MSCT) in SLE patients with refractory cytopenia. Thirty-five SLE patients with refractory cytopenia were enrolled in a MSCT trial. Hematological changes of pre-and post-transplantation were evaluated. Mechanisms for MSCT effects focused on the analysis of percentage of regulatory T cells (Treg) and Th17. The results showed that in 35 SLE patients, 20 patients had leukopenia, 24 with anemia or thrombocytopenia. The average follow-up period after MSCT was 21 months (range 6-45 months). Significant improvements in blood cell count were found after MSCT for most patients, in parallel with the decline of disease activity. Clinical remission was accompanied by increased Treg and decreased Th17. Two patients died of uncontrolled disease recurrence after infection, whereas no adverse events related to transplantation was observed. The result suggested that MSCT could reverse hematological aberration in SLE patients with refractory cytopenia, which might be associated with reconstitution of Treg and Th17. Longer follow-up and clinical larger-scale controlled study, as well as the exact mechanism exploration, will need further investigations.

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“…50-60% of AIHA cases are believed to be secondary [3][4][5]. Major risk factors for secondary AIHA include malignancy [6], viral and mycoplasma infections [7,8], and rheumatologic disorders [9]. AIHA treatment remains largely based on expert opinion without a clear consensus due to limited prospective data [10,11].…”

Section: Introductionmentioning

confidence: 99%

Autoimmune Hemolytic Anemia Confers an Independent Risk Factor for Thrombosis: Retrospective Cohort Study Using the “STRIDE” Database

Kummar¹

2017

Ann Hematol Oncol

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Anaemia in systemic lupus erythematosus: from pathophysiology to clinical assessment

Cited by 162 publications

References 66 publications

Two Years Profile of Anemia in Systemic Lupus Erythematosus Patients at West Java’s Top Referral Hospital, Indonesia

Two Years Profile of Anemia in Systemic Lupus Erythematosus Patients at West Java’s Top Referral Hospital, Indonesia

Mesenchymal SCT ameliorates refractory cytopenia in patients with systemic lupus erythematosus

Autoimmune Hemolytic Anemia Confers an Independent Risk Factor for Thrombosis: Retrospective Cohort Study Using the “STRIDE” Database

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