Anaemia of chronic disease in rheumatoid arthritis: effect of the blunted response to erythropoietin and of interleukin 1 production by marrow macrophages.

Abstract

Anaemia in rheumatoid arthritis (RA)

Depletion of Endothelial Progenitor Cells in the Peripheral Blood of Patients With Rheumatoid Arthritis

“…35 Interestingly, whereas Epo has been shown to mobilize EPCs, 36,37 circulating EPCs were low in RA patients, despite increased Epo concentrations, and there was no correlation between Epo and EPC levels; this may be partly related to Epo resistance, as previously described in RA. 38 However, Epo levels were correlated with CRP.…”

Recombinant Erythropoietin for the Treatment of Anemia in Inflammatory Bowel Disease

“…[4][5][6][7] Such cytokines can contribute to the development of anemia by inducing a relative deficiency of erythropoietin as well as a resistance to erythropoietin on the part of erythroid precursor cells in various in vitro and in vivo models. [8][9][10][11] In these models, administering erythropoietin could reverse most of the suppression related to proinflammatory cytokines of cell maturation of the erythroid lineage. [8][9][10] The use of recombinant erythropoietin (epoetin) to treat anemia in chronic rheumatoid arthri-tis as well as anemia associated with malignant disease has been suggested.…”

“…[8][9][10][11] In these models, administering erythropoietin could reverse most of the suppression related to proinflammatory cytokines of cell maturation of the erythroid lineage. [8][9][10] The use of recombinant erythropoietin (epoetin) to treat anemia in chronic rheumatoid arthri-tis as well as anemia associated with malignant disease has been suggested. 8,11 We studied patients with inflammatory bowel disease who had chronic anemia refractory to oral iron therapy and evaluated treatment with erythropoietin in a double-blind, prospective, randomized trial.…”

Study of erythropoietin in treatment of anaemia in patients with rheumatoid arthritis

“…The effect of erythropoietin on such anaemia is controversial, and evidence exists that cytokines may affect haemopoiesis, possibly by affecting sensitivity to erythropoietin 1,3. We assessed the therapeutic efficacy of human recombinant erythropoietin in the anaemia of chronic disease in rheumatoid arthritis in a randomised, double blind, placebo controlled study over 20 weeks.…”