Anaerobic Exercise Components During the Force-Velocity Test in Sickle Cell Trait

Bilé, A.; Gallais, Daniel Le; Mercier, B.; Martínez, P.; Ahmaı̈di, Saı̈d; Préfaut, C

doi:10.1055/s-2007-972842

Cited by 26 publications

(18 citation statements)

References 8 publications

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“…In conclusion, the present study, together with the findings of Bile et al [3] and Hue et al [12], shows that male SCT carriers are able to perform sprints and brief exercises at the highest levels. These three studies further suggest that brief and intensive exercise performance involving mainly alactic anaerobic metabolism may be enhanced by HbS in elite male sprinters.…”

Section: Physiology and Biochemistrysupporting

confidence: 84%

Sickle Cell Trait in French West Indian Elite Sprint Athletes

Marlin¹,

Etienne‐Julan²,

Gallais³

et al. 2005

Int J Sports Med

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The aim of this study was to establish the percentage of sickle cell trait (SCT) carriers among French West Indian sprinters selected for the French National Team in 2000. The investigation determined the number of SCT carriers and the number of national records they had established. Sixteen athletes were indexed (6 males and 10 females). The athletes were within the ranges of 20-33 years, 161-186 cm and 60-80 kg. The results showed the presence of SCT carriers in this population among whom three were SCT carriers (2 males and 1 female) (18.75%). Moreover, there is a significantly higher percentage of titles and records held by the SCT carriers (38.6% and 50%, respectively). In conclusion, this study shows that sickle cell trait carriers are able to perform sprint exercises at the highest levels, and it further indicates that brief and explosive exercise involving mainly the alactic anaerobic metabolism may be enhanced by HbS.

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Section: Physiology and Biochemistrysupporting

confidence: 84%

Sickle Cell Trait in French West Indian Elite Sprint Athletes

Marlin¹,

Etienne‐Julan²,

Gallais³

et al. 2005

Int J Sports Med

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“…Moreover, no differences in the blood lactate concentrations reached at the end of the T ex test emerged between SCT carriers and control subjects with normal Hb ( Table 2). The similarity between groups for T ex , blood lactate concentrations, and LDH and PFK activities supports previous reports on normal blood lactate concentrations in SCT carriers (3,42). However, such findings were not consistent, as evidenced by other studies showing elevated lactate (18) or reduced lactate (5,21,43) levels in SCT carriers in response to various types of exercise.…”

Section: Sickle Cell Traitsupporting

confidence: 76%

Skeletal muscle structural and energetic characteristics in subjects with sickle cell trait, α-thalassemia, or dual hemoglobinopathy

Vincent

Féasson

Oyono-Enguéllé

et al. 2010

Journal of Applied Physiology

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Previous studies have shown that subjects with sickle cell trait (SCT), alpha-thalassemia (alpha-t), and the dual hemoglobinopathy (SCT/alpha-t) manifest subtle, albeit significant, differences during exercise. To better understand such differences, we assessed skeletal muscle histomorphological and energetic characteristics in 10 control HbAA subjects (C), 5 subjects with alpha-t (alpha-t), 6 SCT carriers (SCT) and 9 SCT carriers with alpha-t (SCT/alpha-t). Subjects underwent a muscle biopsy and also performed an incremental maximal exercise and a time to exhaustion test. There were no observable differences in daily energy expenditure, maximal power output (Pmax), or time to exhaustion at 110% Pmax (Tex) among the groups. Blood lactate concentrations measured at the end of the Tex, muscle fiber type distribution, and mean phosphofructokinase (PFK), lactate dehydrogenase (LDH), beta-hydroxyacyl-CoA-dehydrogenase (HAD), and citrate synthase (CS) activities were all similar among the four groups. However, SCT was associated with a lower cytochrome-c oxidase (COx) activity in type IIa fibers (P<0.05), and similar trends were observed in fiber types I and IIx. Trends toward lower creatine kinase (CK) activity (P=0.0702) and higher surface area of type IIx fibers were observed in SCT (P=0.0925). In summary, these findings support most of the previous observations in SCT, such as 1) similar maximal power output and associated maximal oxygen consumption (VO2max) values and 2) lower exercise performances during prolonged submaximal exercise. Furthermore, performances during short supramaximal exercise were not different in SCT. Finally, the dual hemoglobinopathy condition does not seem to affect muscle characteristics.

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“…In the Gulf region, including Oman, the SCD is the most prevalent genetic blood disorder and it has been reported that 6% of the population are sickle cell gene carriers (traits) [10]. Although previous studies showed a normal exercise tolerance in adult and adolescent HbS carriers [11][12][13], meager data are available on children. Furthermore, although children with sickle cell disease (SCD) or sickle cell trait (SCT) are usually encouraged to be physically active and participate in sport and exercise on a regular basis, no information exists on the anthropometrical characteristics and exercise performance in these children in Sultanate of Oman.…”

Section: Introductionmentioning

confidence: 99%

Physical fitness indices and anthropometrics profiles in schoolchildren with sickle cell trait/disease

2006

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The current studies aimed at determining physical fitness indices and anthropometrics profiles of school children with sickle cell trait (SCT) and sickle cell disease (SCD). Male school children (150) comprising 3 Groups participated in the studies. Group 1 has 50 normal healthy controls, while Groups 2 and 3 each has 50 children who were suffering from SCT and SCD, respectively. Anthropometrics measurement and parameters of physical fitness were assessed in all subjects. All children were also subjected to a 5-min running exercise test on a flat motorized treadmill at speed corresponding to 5 km/hr. Throughout the test, heart rate was monitored and recoded during exercise and for 10-min during recovery. Blood lactate was measured before and 5 min following the completion of test. The mean values of lean body mass and height were lower in the SCD children (P < 0.05) compared with the healthy subjects and SCT individuals. Children with SCD exhibited a higher mean value (P < 0.05) for percent body fat and fat mass than the normal healthy subjects and SCT individuals. Although all groups tolerated well the treadmill exercise protocol, the SCD group exhibited higher (P < 0.05) mean values of heart rate during exercise than those observed in the SCT and normal control children. In addition, SCD children showed higher serum lactate values before and after treadmill exercise compared to the other groups. Children with SCD exhibit high level of adiposity; low level of fitness and their exercise performance appears to be physiologically more stressful as indicated by heart rate and blood lactate concentration responses. Am. J. Hematol. 82:91-97, 2007. V V C 2006 Wiley-Liss, Inc.

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Anaerobic Exercise Components During the Force-Velocity Test in Sickle Cell Trait

Cited by 26 publications

References 8 publications

Sickle Cell Trait in French West Indian Elite Sprint Athletes

Sickle Cell Trait in French West Indian Elite Sprint Athletes

Skeletal muscle structural and energetic characteristics in subjects with sickle cell trait, α-thalassemia, or dual hemoglobinopathy

Physical fitness indices and anthropometrics profiles in schoolchildren with sickle cell trait/disease

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