Anaerobic Vaginosis (Non-Specific Vaginitis): Clinical, Microbiological, and Therapeutic Findings

Blackwell, A L; Phillips, Ian; Fox, AllanR.; Barlow, David H.

doi:10.1016/s0140-6736(83)90920-0

Cited by 138 publications

(95 citation statements)

References 13 publications

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“…G. vaginalis occurred in numbers exceeding 106 CFU/ml in 77 of 78 clue cell-positive vaginal discharges (17). Further, between 93 and 100% of women suffering from bacterial vaginosis were heavily colonized by G. vaginalis (8,18,65,89,92,94,167,170,226), and the numbers of CFU in samples from diseased vaginas were much higher than in healthy vaginas according to most (5,182,213,219,233), but not all (25,137), authors.…”

Section: Significance Of G Vaginalis Inmentioning

confidence: 94%

“…17) were important in focusing attention on the joint roles of anaerobes and G. vaginalis in the disease process, and their findings have been amply confirmed (16,26,168,216). The anaerobes recovered from high percentages of women with vaginosis and found in high numbers in quantitative cultures of vaginal secretions included species of Prevotella, Bacteroides, Peptostreptococcus, and Fusobacterium (17,88,89,95,137,159,167,201,210,219). In addition, anaerobic, motile, curved rods (Mobiluncus spp.…”

Section: Significance Of G Vaginalis Inmentioning

confidence: 95%

“…Metronidazole is commonly used and gives initial cure rates of approximately 90% or better (8,17,79,108,146,167,170,226,237). Metronidazole becomes widely distributed in the body and undergoes oxidative metabolism in the liver, with the formation of several metabolites (132).…”

Section: Susceptibility To Chemotherapeutic Agentsmentioning

confidence: 99%

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Gardnerella vaginalis: characteristics, clinical considerations, and controversies

1992

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The clinical significance, Gram stain reaction, and genus affiliation of Gardnerella vaginalis have been controversial since Gardner and Dukes described the organism as the cause of "nonspecific vaginitis," a common disease of women which is now called bacterial vaginosis. The organism was named G. vaginalis when taxonomic studies showed that it was unrelated to bacteria in various genera including Haemophilus and Corynebacterium. Electron microscopy and chemical analyses have elucidated the organism's gram-variable reaction. Controversy over the etiology of bacterial vaginosis was largely resolved by (i) studies using improved media and methods for the isolation and identification of bacteria in vaginal fluids and (ii) standardization of criteria for clinical and laboratory diagnosis. Besides G. vaginalis, Mobiluncus spp., Mycoplasma hominis, and certain obligate anaerobes are now acknowledged as participants in bacterial vaginosis. The finding that G. vaginalis, Mobiluncus spp., and M. hominis inhabit the rectum indicates a potential source of autoinfection in addition to sexual transmission. Extravaginal infections with G. vaginalis are increasingly recognized, especially when the toxic anticoagulant polyanetholesulfonate is omitted from blood cultures and when urine cultures are incubated anaerobically for 48 h. The finding that mares harbor G. vaginalis suggests that an equine model can be developed for studies of Gardnerella pathogenesis.

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Section: Significance Of G Vaginalis Inmentioning

confidence: 94%

Section: Significance Of G Vaginalis Inmentioning

confidence: 95%

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Gardnerella vaginalis: characteristics, clinical considerations, and controversies

1992

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“…It is a disorder of the vaginal ecosystem characterized by a shift in the vaginal flora from the normally predominant Lactobacillus (7,18) to one dominated by a mixed flora including Gardnerella vaginalis (2,7,15,18,19) and Mobiluncus (2,15,19), Prevotella (2,3,15,18), Bacteroides (2,3,7,15), and Mycoplasma (2,7,15,18) species. Although the condition is associated with abnormal vaginal discharge, about half of the women with BV, diagnosed by the Amsel criteria, are symptom free (1).…”

mentioning

confidence: 99%

BVBlue Test for Diagnosis of Bacterial Vaginosis

Myziuk

Romanowski

Johnson³

2003

J Clin Microbiol

134

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“…Quanto ao whiff test, foi positivo em 10 (9,6%) mulheres menopausadas e em 13 (15,1%) inférteis. Segundo Blackwell et al 25 , parece que o componente anaeróbico, mais do que a Gardnerella, é responsável pelo teste das aminas positivo, teste este que depende do volume da secreção vaginal e da concentração das aminas nesta secreção 5 . Assim, os resultados falso-negativos que observamos em nosso estudo poderiam ser explicados pela presença de um corrimento profuso com baixa concentração de aminas ou vice-versa.…”

Section: Discussionunclassified

Vaginose Bacteriana em Mulheres com Infertilidade e em Menopausadas

Wanderley¹,

Miranda²,

Freitas³

et al. 2001

Rev. Bras. Ginecol. Obstet.

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IntroduçãoA vaginose bacteriana (VB) é considerada, atualmente, a infecção vaginal de maior prevalência em mulheres em idade reprodutiva [1][2][3] . Staphylococcus spp e Streptococcus spp tem sido, junto com a Gardnerella, altamente associada com esta condição 5,6 . De etiologia não definida 2 , a VB é conceituada hoje como uma alteração da flora vaginal em que os lactobacilos, normalmente predominantes, são substituídos por uma flora complexa abundante, dominada por bactérias anaeróbias estritas e facultativas 6,7 , podendo também ser observados padrões intermediários de flora vaginal em que os microrganismos anaeróbios e lactobacilos coexistem

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Anaerobic Vaginosis (Non-Specific Vaginitis): Clinical, Microbiological, and Therapeutic Findings

Cited by 138 publications

References 13 publications

Gardnerella vaginalis: characteristics, clinical considerations, and controversies

Gardnerella vaginalis: characteristics, clinical considerations, and controversies

BVBlue Test for Diagnosis of Bacterial Vaginosis

Vaginose Bacteriana em Mulheres com Infertilidade e em Menopausadas

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