Anaerobiosis ofPseudomonas aeruginosa: Implications for Treatments of Airway Infection

Abstract

Pseudomonas aeruginosa, as an opportunistic pathogen, establishes a chronic infection in the respiratory track of patients suffering from pneumonia and bronchiectasis, including cystic fibrosis. Biofilm formation inside the oversecreted mucus layer lining the patient airway and production of virulence factors, a process controlled by quorum sensing, are considered to be the major virulence determinants in P. aeruginosa pathogenesis. Recently, an abnormally thickened mucus layer was proven to be anaerobic. Given the fact that currently used antibiotics are less effective under anaerobic environments, these new findings lead us to change the way we confront P. aeruginosa infection. This article reviews pathological features of patient airways that become susceptible to P. aeruginosa infection and bacterial adaptation that contributes to the prolonged survival inside the patient airway.

Coupling of Protonation, Reduction, and Conformational Change in azurin from Pseudomonas aeruginosa Investigated with Free Energy Measures of Cooperativity

“…Electron transfer with all known possible redox partners can also be fulfilled by other electron carriers such as cytochrome c 551 . , The understanding of the respiratory system of P. aeruginosa is also of medical interest, because this bacterium occurs as opportunistic pathogen in human diseases such as cystic fibrosis. , Such understanding could aid in the search for potent drugs against P. aeruginosa.…”

“…aeruginosa. The search for such drugs is especially important, because strains of the bacterium appeared among the multidrug-resistant pathogens that have become a major problem in medicine. , …”

“…3,4 The understanding of the respiratory system of P. aeruginosa is also of medical interest, because this bacterium occurs as opportunistic pathogen in human diseases such as cystic fibrosis. 5,6 Such understanding could aid in the search for potent drugs against P. aeruginosa. The search for such drugs is especially important, because strains of the bacterium appeared among the multidrug-resistant pathogens that have become a major problem in medicine.…”

“…The search for such drugs is especially important, because strains of the bacterium appeared among the multidrug-resistant pathogens that have become a major problem in medicine. 5,6 In the past years, PaAz has found renewed interest as a potential therapeutic agent against cancer cells, 7 malaria pathogens, and HIV. 8 The basis for such applications is the ability of PaAz to induce apoptosis in mammalian cells.…”