Anaesthesia and anti-cancer chemotherapeutic drugs

Huettemann, Egbert; Sakka, Samir G.

doi:10.1097/01.aco.0000169240.14056.19

Cited by 42 publications

(10 citation statements)

References 47 publications

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“…Over half a million deaths were attributed to cancer during 2004 16 . Approximately half of cancer patients will develop metastatic disease, and over 70% of them will develop symptoms from either their primary or metastatic disease 17 . Increasing number of patients will have surgical intervention at some point of their treatment, usually for resection of the primary tumor or for emergency surgery for the complications of the disease.…”

Section: Patients With Cancermentioning

confidence: 99%

“…Among the various agents, bleomycin is the most important cause of pulmonary toxicity which may lead to pulmonary fibrosis. Bleomycin produces pulmonary toxic effects in 2-40% of patients receiving the drug 20 , and up to 25% of patients with previous bleomycin therapy may develop postoperative respiratory insufficiency necessitating prolonged postoperative tracheal intubation 17,21 . Excessive fluid intake, perioperative transfusion, decrease in vital capacity, and duration of surgery are additional factors predisposing to postoperative respiratory insufficiency.…”

Section: Systemic Effects Of the Cancermentioning

confidence: 99%

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Preoperative assessment of the immunocompromised patient

Nešković

2011

ACTA CHIR IUG

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In some surgical patients immunosuppression is easily apparent and directly caused by known underlying disease or treatment. In others, although induced by the underlying disease, immunosuppression may be less obvious. Perioperative management of immunocompromised patient is mostly directed by the fact that immunosuppression itself does not cause pathology, but does leave the patient prone to infection. Immunodeficiency can be broadly characterized as congenital (primary) or acquired (secondary). The majority of immune deficiencies that are of interest to the anaesthetist are acquired. They can be present both in children and adults, in a huge variety of patients that are presented preoperatively. Most of them do not require different than usual perioperative anaesthetic management. However, in some of them specific aspects of treatment should be considered, such as HIV infected, cancer, transplant patients, and those scheduled for organ transplantation.

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Section: Patients With Cancermentioning

confidence: 99%

Section: Systemic Effects Of the Cancermentioning

confidence: 99%

Preoperative assessment of the immunocompromised patient

Nešković

2011

ACTA CHIR IUG

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“…As a result, many cancer patients die of pneumonitis, septicemia, uremia, or other secondary diseases, rather than from the cancer itself (Chihara 1992;Huettemann and Sakka 2005). Therefore, it is important to find new, powerful anticancer agents that are nontoxic and biocompatible.…”

Section: Introductionmentioning

confidence: 99%

Antitumor activity of methylan polysaccharide derivatives

et al. 2010

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“…Alkylating agents that have been associated with cardiotoxicity include cyclophosphamide, mitomycin, ifosfamide, cisplatin, carmustine, and busulfan (34,44). Cyclophosphamide in high doses (i.e.…”

mentioning

confidence: 99%

Anesthetic considerations for the pediatric oncology patient – part 2: systems‐based approach to anesthesia

Latham

Greenberg

2010

Pediatric Anesthesia

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One of the prices paid for chemo- and radiotherapy of cancer in children is damage to the vulnerable and developing healthy tissues of the body. Such damage can exist clinically or subclinically and can become apparent during active antineoplastic treatment or during remission decades later. Furthermore, effects of the tumor itself can significantly impact the physiologic state of the child. The anesthesiologist who cares for children with cancer or for survivors of childhood cancer should understand what effects cancer and its therapy can have on various organ systems. In part two of this three-part review, we review the anesthetic issues associated with childhood cancer. Specifically, this review presents a systems-based approach to the impact from both tumor and its treatment in children, followed by a discussion of the relevant anesthetic considerations.

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Anaesthesia and anti-cancer chemotherapeutic drugs

Abstract: Anti-cancer chemotherapeutic drugs may cause generalized and specific organ toxicities and may also give rise to various unpredictable or life-threatening peri-operative complications, rendering a detailed pre-operative assessment of patients with previous chemotherapy mandatory.

Cited by 42 publications

References 47 publications

Preoperative assessment of the immunocompromised patient

Preoperative assessment of the immunocompromised patient

Antitumor activity of methylan polysaccharide derivatives

Anesthetic considerations for the pediatric oncology patient – part 2: systems‐based approach to anesthesia

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