Anaesthesia with Ketamine and Thiopentone for Short Surgical Procedures

Dobson, Matthew

doi:10.1097/00132586-197902000-00036

Cited by 2 publications

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“…27 28 The absence of an increase in CO, despite the decrease in systemic vascular resistance and maintenance of constant cardiac filling pressures, could be related to the negative inotropic properties of ketamine at the dose used in our study, 27 39 as suggested by the decrease in left ventricular stroke work in the presence of a constant PAOP. Previous administration of thiopental at induction of anaesthesia might also have blunted the cardiovascular stimulant properties of ketamine, 40 although we used very small doses of thiopental and the actual procedure started at least 2 h after administration of thiopental. Even more surprising was the significant decrease in HR during haemodilution in our animals.…”

Section: Discussionmentioning

confidence: 99%

Critical haemoglobin concentration in anaesthetized dogs: comparison of two plasma substitutes

Linden¹,

Schmartz²,

Groote³

et al. 1998

British Journal of Anaesthesia

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We have explored systemic and regional tolerance to haemodilution during anaesthesia with two different synthetic colloids. Eighteen dogs undergoing mechanical ventilation during anaesthesia with ketamine were submitted to progressive normovolaemic haemodilution with either gelatin (GEL; n = 9) or hydroxyethylstarch (HES; n = 9) administered on a 1:1 ratio. Systemic oxygen delivery was calculated from measurement of thermodilution cardiac output and arterial oxygen content, while systemic oxygen consumption was determined from expired gas analysis. Mesenteric oxygen delivery and consumption were determined using ultrasonic flow measurements, and arterial and mesenteric venous oxygen contents. The critical haemoglobin concentration (i.e. the haemoglobin value below which oxygen consumption becomes oxygen delivery dependent) was mean 3.6 (SD 0.8) g dl-1 in the GEL and 3.5 (1.5) g dl-1 in the HES group. The mesenteric critical oxygen extraction ratio (O2ER) (GEL 50.1 (12.1)%; HES 48.5 (13.4)%) was significant lower than the systemic critical O2ER (GEL 66.1 (8.4)%; HES 67.7 (7.1)%). There were no significant differences between the GEL and HES groups for any of these variables, or in the amount of colloid administered. During the study, oxygen delivery decreased almost linearly with reduction in haemoglobin, indicating a lack of cardiac output response to anaemia during ketamine anaesthesia.

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Section: Discussionmentioning

confidence: 99%

Critical haemoglobin concentration in anaesthetized dogs: comparison of two plasma substitutes

Linden¹,

Schmartz²,

Groote³

et al. 1998

British Journal of Anaesthesia

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“…Administration of thiopentone combined with ketamine can also reduce sympathetic stimulation. 24 The effect of ketamine on cardiac rhythm is con troversial. There are animal data suggesting that ketamine sensitizes the myocardium to the dys rhythmogenic effects of adrenaline.…”

Section: Cardiovascular Systemmentioning

confidence: 99%

Pharmacological Aspects and Potential New Clinical Applications of Ketamine: Reevaluation of an Old Drug

Aroni

Iacovidou

Dontas

et al. 2009

The Journal of Clinical Pharma

161

107

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Ketamine, the phencyclidine derivative described in 1965, is an intravenous anesthetic with a variety of applications. The enthusiasm following its initial release subsided due to side effects from the central nervous system. New anesthetics limited the role of ketamine in anesthetic practice. However, its hemodynamically stable profile, along with its beneficial respiratory properties and analgesic potency, rendered the drug invaluable in battlefield medicine, sedation of the uncooperative child, analgesia, and sedation in burn units. Reevaluation, though, of analgesic properties of ketamine resulted in new interest regarding its use in perioperative and chronic pain management. Moreover, recent studies in the effects of the substance on intracranial pressure and cerebral blood flow led to revising the recommendation against its use in brain injury. Furthermore, the bronchodilating effects of the substance led to increasing interest for potential use in asthma treatment. In addition, separation of the 2 enantiomers and subsequent separate studies indicated beneficial results of the S(+) one. Thus, new controlled multicentered clinical trials are to be conducted to justify approval for new uses of ketamine and take advantage of its unique range of applications.

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Anaesthesia with Ketamine and Thiopentone for Short Surgical Procedures

Cited by 2 publications

References 0 publications

Critical haemoglobin concentration in anaesthetized dogs: comparison of two plasma substitutes

Critical haemoglobin concentration in anaesthetized dogs: comparison of two plasma substitutes

Pharmacological Aspects and Potential New Clinical Applications of Ketamine: Reevaluation of an Old Drug

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