Anaesthetic Agents and the Ozone Layer

Hutton, Peter; Kerr, J. A.; Pierce, J.M.T.; Linter, S.P.K.

doi:10.1016/s0140-6736(89)92646-9

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…Since the work published by Fox et al in 1975, 1 more public attention has been directed towards addressing the potential damage that the release of halogenated general anaesthetic gases constitutes for the global environment. [2][3][4][5][6][7][8] All the species that are currently employed as volatile anaesthetics (namely, desurane, enurane, halothane, isourane and sevourane) are halogenated organic compounds potentially noxious to the ozone layer. As modern anaesthesia becomes more and more available to the world population, the global usage of volatile anaesthetics is quickly growing.…”

Section: Introductionmentioning

confidence: 99%

A chromium-based metal organic framework as a potential high performance adsorbent for anaesthetic vapours

et al. 2014

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In this work, a chromium-based metal organic framework (Cr-MOF) was synthesized, characterized and tested for the adsorption of a model highly ozone-depleting anaesthetic (sevoflurane). Adsorption isotherms were measured at different temperatures e.g., 283, 298, 313 and 328 K on both Cr-MOF and a conventionally used reference adsorbent. At the temperatures used in this study, the Cr-based MOF showed a significantly higher sevoflurane (selected anaesthetic) equilibrium adsorption capacity compared to the reference sample, although adsorption on the selected MOF did not take place on all active sites (i.e., it did not expose its coordinatively unsaturated sites). Moreover, sevoflurane adsorption on Cr-MOF was found to be fully reversible in the 283–328 K temperature range, and the adsorbent was fully regenerated by vacuum treatment at ambient temperature. The semiempirical Sips model was successfully used to fit sevoflurane adsorption data, substantially confirming the phenomenological aspects of the process inferable from the experimental results

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Section: Introductionmentioning

confidence: 99%

A chromium-based metal organic framework as a potential high performance adsorbent for anaesthetic vapours

et al. 2014

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“…A recent letter in the Lancet (1 1) expressed concern about the effects of halogenated volatile anaesthetics on the integrity of the ozone layer and received wide publicity in the popular press. Subsequent correspondence did, however, put this possibility into a more realistic perspective (12,13). Although production figures are not available, it was estimated that the world production of halothane, enflurane and isoflurane totalled 6400 tonnes compared with an annual global production of CFC-11 and CFC-12 of 630,000 tonnes ( 3 ) .…”

Section: N Stokes and P Huttonmentioning

confidence: 99%

“…It is also by no means clear whether or not volatile anaesthetics would ever reach the ozone layer in the stratosphere because their C-H bonds are likely to be attacked by the hydroxyl radical which is a tropospheric scavenging agent (1 1, 12). Nevertheless, it should be emphasized that atmospheric reactions which involve halogenated compounds are very difficult to predict correctly (12). A world literature search, undertaken within the last 2 months, failed to reveal any experimental work which had been published in this area.…”

Section: N Stokes and P Huttonmentioning

confidence: 99%

Anaesthesia Goes Green

Stokes

Hutton

1990

J Clin Pharm Ther

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A relative rate study of the reaction of chlorine atoms (Cl) and hydroxyl radicals (OH) with a series of ethers

McLoughlin

Kane

Shanahan

1993

Int J of Chemical Kinetics

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Rate constants for the gas phase reactions of hydroxyl radicals and chlorine atoms with a number of ethers have been determined at 300 2 3 K and at a total pressure of 1 atmosphere. Both OH radical and chlorine atom rate constants were determined using a relative rate technique. Values for the rate constants obtained are as follows. CompoundHexane 5.53 2 1.55 2 4.4The above relative rate constants are based on the values of k(OH + pentane) = [3.94 2 0.981 X lo-'' and k(OH + diethyl ether) = [13.6 2 2.263 X lo-'' cm3 molecule-' s-l in the case of the hydroxyl reactions. In the case of the chlorine atom reactions, the above rate constants are based on values of k(C1 + ethane) = f5.84 2 0.881 X lo-" and k(C1 + diethyl ether) = L25.4 2 8.053 X lo-" cm3 molecule-' s-'. The quoted errors include 2 2 u from a least squares analysis of our slopes plus the uncertainty associated with the reference rate constants.Atmospheric lifetimes calculated with respect to reaction with OH radicals are based on a tropospheric OH radical concentration of (7.7 2 1.4) x lo5 radicals ~m -~, and lifetimes with respect to reaction with C1 atoms are based on a tropospheric C1 atom concentration of 1 x lo3 atoms ~m -~. Observed trends in the relative rates of reaction of hydroxyl radicals and chlorine atoms with the ethers studied is discussed. The significance of the calculated tropospheric lifetimes is also reviewed. 0 1993 John Wiley & Sons, Inc.

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Anaesthetic Agents and the Ozone Layer

Cited by 5 publications

References 2 publications

A chromium-based metal organic framework as a potential high performance adsorbent for anaesthetic vapours

A chromium-based metal organic framework as a potential high performance adsorbent for anaesthetic vapours

Anaesthesia Goes Green

A relative rate study of the reaction of chlorine atoms (Cl) and hydroxyl radicals (OH) with a series of ethers

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