Anaesthetic and cardiorespiratory effects of a constant rate infusion of fentanyl in isoflurane-anaesthetized sheep

Funes, Francisco J.; Granados, María del Mar; Morgaz, Juán; Navarrete, Rocío; Fernández-Sarmiento, José Andrés; Gómez-Villamandos, R.J.; Muñoz, Patricia; Quirós, Setefilla; Carrillo, José M.; Lopez-Villalba, I.; Domínguez, Juan M.

doi:10.1111/vaa.12216

Cited by 21 publications

(24 citation statements)

References 25 publications

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“…It was expected that the association of acepromazine to the opioids could provide better sedation, as described in dogs [4], but the data in the present study suggest that these effects may not occur in sheep. Morphine and fentanyl decrease minimal alveolar concentration of isoflurane in goats and ewes, respectively [8, 9], highlighting the sparing capacity effect of opioids in small ruminants, although these aspects were not assessed in this study.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Acepromazine Alone or in Combination with Methadone, Morphine, or Tramadol on Sedation and Selected Cardiopulmonary Variables in Sheep

Nishimura

Villela

Carvalho

et al. 2017

Veterinary Medicine International

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The sedative and selected cardiopulmonary effects of acepromazine alone or in combination with methadone, morphine, or tramadol were compared in sheep. Six ewes were randomly assigned to treatments: A (0.05 mg/kg acepromazine), AM (A plus 0.5 mg/kg methadone), AMO (A plus 0.5 mg/kg morphine), and AT (A plus 5 mg/kg tramadol). Parameters were assessed before sedative drug administration (baseline) and every 15 minutes thereafter, for two hours. Treatments A and AM were associated with increases in sedation score for 60 minutes and treatments AMO and AT for 30 minutes; however, there were no significant differences between treatments. There was a decrease in mean arterial pressure compared to baseline values in treatment A at 15, 45, 60, and 90 minutes, in treatment AM at 15 minutes, and in treatment AT from 45 to 120 minutes. Arterial blood carbon dioxide pressure increased at all time points in all treatments. Arterial oxygen pressure decreased in treatment AMO at 15, 30, and 120 minutes and in treatment AT at 15–45, 105, and 120 minutes, compared to baseline. Acepromazine alone causes a level of sedation similar to that observed when it is coadministered with opioids methadone, morphine, and tramadol. These combinations did not cause clinical cardiopulmonary changes.

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Section: Discussionmentioning

confidence: 99%

The Effect of Acepromazine Alone or in Combination with Methadone, Morphine, or Tramadol on Sedation and Selected Cardiopulmonary Variables in Sheep

Nishimura

Villela

Carvalho

et al. 2017

Veterinary Medicine International

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“…Hematocrit values taken from the arteria femoralis increased over time in both groups. This may be a result of the only moderate volume substitution, aiming at constant blood pressure, during anesthesia, which is accompanied by a mild loss of fluid volume (2,19).…”

Section: Discussionmentioning

confidence: 99%

Increase of cortical cerebral blood flow and further cerebral microcirculatory effects of Serelaxin in a sheep model

Bischoff

Schmidt

Irintchev

et al. 2016

American Journal of Physiology-Heart and Circulatory Physiology

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Serelaxin, recombinant human relaxin-2, modulates endothelial vasodilatory functionality and is under evaluation for treatment of acute heart failure. Little is known about acute effects on cerebral perfusion. We tested the hypothesis that Serelaxin might also have effects on the cerebral microcirculation in a sheep model, which resembles human brain structure quite well. We used laser Doppler flowmetry and sidestream dark-field (SDF) imaging techniques, which are reliable tools to continuously assess dynamic changes in cerebral perfusion. Laser Doppler flowmetry shows that bolus injection of 30 g Serelaxin/kg body wt induces an increase (P ϭ 0.006) to roughly 150% of cortical cerebral blood flow (CBF), whereas subcortical CBF remains unchanged (P ϭ 0.688). The effects on area-dependent CBF were significantly different after the bolus injection (P ϭ 0.042). Effects on cortical CBF were further confirmed by SDF imaging. The bolus injection of Serelaxin increased total vessel density to 127% (P ϭ 0.00046), perfused vessel density to 145% (P ϭ 0.024), and perfused capillary density to 153% (P ϭ 0.024). Western blotting confirmed the expression of relaxin receptors RXFP1 and truncated RXFP2-variants in the respective brain regions, suggesting a possible contribution of RXFP1 on the effects of Serelaxin. In conclusion, the injection of a high dose of Serelaxin exerts quick effects on the cerebral microcirculation. Therefore, Serelaxin might be suitable to improve cortical microcirculation and exert neuroprotective effects in clinically relevant scenarios that involve cortical hypoperfusion. These findings need to be confirmed in relevant experimental settings involving cerebral cortical hypoperfusion and can possibly be translated into clinical practice. RELAXIN-2 IS A HUMAN HORMONE that mediates cardiovascular adaptations during pregnancy and particularly systemic and renal vasodilatation (7). Moreover, these effects are observed in nonpregnant animals and in ex vivo studies following the artificial administration of the substance as well (33). An intravenous bolus injection of a recombinant form of human relaxin-2, Serelaxin (Novartis Pharma, Basel, Switzerland), modulates a sustained endothelial vasodilatory function. Serelaxin mediates systemic hemodynamic changes and increases renal blood flow through a fall in systemic intravascular resistance with a concomitant increase in arterial compliance (15,22,31,38,39). In the RELAX-AHF study, cardiovascular and all-cause mortality was reduced 37% in patients treated with Serelaxin (42). Furthermore, initial positive studies on the cerebral effects of this peptide hormone in a stroke model (47) and in a high blood pressure situation (6) have already been published. Serelaxin induces a nitric oxide-mediated vasodilatation (40) and can particularly reduce the infarction size of the cerebral cortex, suggesting a neuroprotective effect (47).Nonetheless, studies on the influence of Serelaxin on the cerebral blood flow (CBF) have not been performed to this day. Moreover, desp...

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“…Although oxymorphone and hydromorphone are commonly used in small animal practice for their analgesic and MAC-sparing effects, 14 their use in sheep has not been reported, to the authors' knowledge. 17 Similarly, a dose-dependent reduction in MAC can be achieved with IV administration of fentanyl to healthy, mechanically ventilated goats. 17 Similarly, a dose-dependent reduction in MAC can be achieved with IV administration of fentanyl to healthy, mechanically ventilated goats.…”

Section: Et Desmentioning

confidence: 99%

“…18 In dogs and primates, opioid administration results in intense MAC-sparing effects and analgesia. 16,17 Although opioids are not considered particularly effective analgesic agents for small ruminants, opioid administration can result in analgesia in response to thermal stimuli and have variable analgesic effects in response to mechanical noxious stimuli. 16,17 Although opioids are not considered particularly effective analgesic agents for small ruminants, opioid administration can result in analgesia in response to thermal stimuli and have variable analgesic effects in response to mechanical noxious stimuli.…”

Section: Et Desmentioning

confidence: 99%

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Effects of oxymorphone hydrochloride or hydromorphone hydrochloride on minimal alveolar concentration of desflurane in sheep

Sayre¹,

Lepiz²,

Horsley³

et al. 2015

ajvr

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Anaesthetic and cardiorespiratory effects of a constant rate infusion of fentanyl in isoflurane-anaesthetized sheep

Cited by 21 publications

References 25 publications

The Effect of Acepromazine Alone or in Combination with Methadone, Morphine, or Tramadol on Sedation and Selected Cardiopulmonary Variables in Sheep

The Effect of Acepromazine Alone or in Combination with Methadone, Morphine, or Tramadol on Sedation and Selected Cardiopulmonary Variables in Sheep

Increase of cortical cerebral blood flow and further cerebral microcirculatory effects of Serelaxin in a sheep model

Effects of oxymorphone hydrochloride or hydromorphone hydrochloride on minimal alveolar concentration of desflurane in sheep

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