Anaesthetic Consideration in Patients of Down’s Syndrome

Abstract

The perimenarcheal onset of polycystic ovarian syndrome (PCOS) has long been recognized, through both its pathophysiology and the frequent onset of hirsutism and menstrual irregularities in this age group. However, there is often a delay in diagnosing PCOS in adolescence because menstrual irregularity is frequently thought to be normal in the first 2 or 3 years after menarche, particularly if clinical signs of hyperandrogenism such as hirsutism or acne are mild or absent. This was a Cross-sectional Study consisting of 102 adolescent girls, aged 12 to 19 years, selected from patients attending the Gynecology Outpatient Clinic. In present study, level of insulin resistance along with markers of PCOS was assessed and compared in adolescent women with (cases) or without (controls) menstrual irregularities, a hall mark of PCOS. 18(35.29%) cases versus 01(1.96%) controls the Rotterdam criteria of PCOS. Clinical manifestations of hyper androgenism were not yet present in all cases who met Rotterdam criteria of PCOS, suggesting menstrual irregularity, especially oligomenorrhoea (83.3% of all PCOS (cases), as the most precocious marker of PCOS. CONCLUSIONS: Adolescents with persistent menstrual irregularities 2 years after menarche frequently have PCOS and elevated HOMA-IR values than controls, indicating a high probability of developing insulin resistance and metabolic syndrome later in life.

Anaesthetic Management in a Congenital Catharact Patient with Down Syndrome

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Ameliorative Effect of Azolla Pinnata Ethanolic Extract on Ranitidine-Induced Hepatotoxicity in Rats

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