2019
DOI: 10.1016/s0140-6736(19)32315-3
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Anaesthetic depth and complications after major surgery: an international, randomised controlled trial

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Cited by 133 publications
(88 citation statements)
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“…Several early studies proposed statistical relationship between low BIS value (< 40 or 45) and postoperative mortality [ 4 6 ]. However, the cumulative duration of BIS value less than 40 or 20, and EEG suppression alone were not related to postoperative mortality in this study, consistent with previous further observational studies, randomized controlled trial, and meta-analysis [ 7 , 9 , 12 , 17 , 18 ]. In contrast, other previous studies showed the association between postoperative mortality and ‘double low’ of BIS and MAP, [ 9 , 12 14 ] similar to our results.…”
Section: Discussionsupporting
confidence: 91%
“…Several early studies proposed statistical relationship between low BIS value (< 40 or 45) and postoperative mortality [ 4 6 ]. However, the cumulative duration of BIS value less than 40 or 20, and EEG suppression alone were not related to postoperative mortality in this study, consistent with previous further observational studies, randomized controlled trial, and meta-analysis [ 7 , 9 , 12 , 17 , 18 ]. In contrast, other previous studies showed the association between postoperative mortality and ‘double low’ of BIS and MAP, [ 9 , 12 14 ] similar to our results.…”
Section: Discussionsupporting
confidence: 91%
“…While in Readtke's report [39] , it was shown that the use of processed EEG had no influence on the 3-month mortality rate. Furthermore, a previous meta-analysis indicated that deep anesthesia had no effect on long-term mortality [57] , which is consistent with a recently published multicenter RCT [58] .…”
Section: Discussionsupporting
confidence: 87%
“…All anesthesiologists were experienced in the interpretation and usage of BIS monitoring. In general, BIS values of 40-60 are indicative of a state of general anesthesia [10].…”
Section: Methodsmentioning
confidence: 99%
“…The mean BIS score in the BIS visible group was 43.7 (SD 7.59), and 42.2 (SD 7.84) in the BIS blinded group, with a p-value of 0.4935, indicating no significant difference between the groups. Furthermore, the consumption of anesthetic agents may change according to age, so the BIS score by age group [2][3][4][5][6], [7][8][9][10][11][12][13] was summarized and is shown in Table 5. The area under the curve was compared between the two groups, with the BIS visible group having a mean AUC of 6079.5 (SD 4989.49), and the BIS blind group having a mean AUC of 3556.6 (SD 1554.43).…”
Section: Baseline Characteristicsmentioning
confidence: 99%