Anaesthetic implications of a patient with cold-induced anaphylaxis presenting to the labour ward

Starsmore, L.; Durbridge, J.

doi:10.1016/j.ijoa.2018.09.009

Cited by 4 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cold avoidance measures are of primary importance in ColdU 1,120,132 and include lifestyle modifications and normothermic conditions during surgery or labour (Table 7). [153][154][155] However, the effectiveness of cold avoidance measures is limited, and their effects including those on patient's QoL warrant further research (Table 1, Section 10). controlled studies (RCTs) proved sgAH effective in ColdU.…”

Section: The Importance Of Avoiding and Mitigating Triggersmentioning

confidence: 99%

Cold urticaria – What we know and what we do not know

Maltseva

Borzova

Fomina

et al. 2020

Allergy

View full text Add to dashboard Cite

Cold urticaria (ColdU) is a common form of chronic inducible urticaria characterized by the development of wheals, angioedema or both in response to cold exposure. Recent research and guideline updates have advanced our understanding and management of ColdU. Today, its pathophysiology is thought to involve the cold‐induced formation of autoallergens and IgE to these autoallergens, which provoke a release of proinflammatory mediators from skin mast cells. The classification of ColdU includes typical and atypical subtypes. We know that cold‐induced wheals usually develop on rewarming and resolve within an hour and that anaphylaxis can occur. The diagnosis relies on the patient's history and cold stimulation testing. Additional diagnostic work‐up, including a search for underlying infections, should only be done if indicated by the patient's history. The management of ColdU includes cold avoidance, the regular use of nonsedating antihistamines and the off‐label use of omalizumab. However, many questions regarding ColdU remain unanswered. Here, we review what is known about ColdU, and we present important unanswered questions on the epidemiology, underlying pathomechanisms, clinical heterogeneity and treatment outcomes. Our aim is to guide future efforts that will close these knowledge gaps and advance the management of ColdU.

show abstract